Translational Pilot Project Program

转化试点项目计划

• 批准号: 10415953
• 负责人: WILLIAM S WARD
• 金额: $ 36.02万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-13 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415953
• 关键词: Applications Grants; Applied Research; Appointment; Award; Basic Science; Biogenesis; Center for Translational Science Activities; Centers of Research Excellence; Cessation of life; Clinical; Clinical Research; Collaborations; Custom; Development; Developmental Biology; Discipline of obstetrics; Endowment; Epigenetic Process; Extramural Activities; Faculty; Funding; Future; Goals; Growth; Gynecology; Institutes; Institution; Investments; Malignant Childhood Neoplasm; Maternal-fetal medicine; Medical; Mentors; Phase; Physicians; Pilot Projects; Placenta Diseases; Productivity; Reproductive Biology; Research; Research Personnel; Research Project Grants; Safety; Scientist; Series; Teacher Professional Development; Techniques; Translational Research; Translations; United States National Institutes of Health; Women' s Health; arm; career development; clinical application; design; faculty mentor; flexibility; innovation; medical schools; member; men; obese mothers; programs; recruit; research facility; success; ward

PROJECT SUMMARY/ABSTRACT – Translational Pilot Project Program With IDeA funding, the Institute for Biogenesis Research (IBR) has thrived, developing from a small, newly formed institution with three faculty to a world renown center for developmental and reproductive biology with fourteen faculty in four different departments. The overall objective of the IBR-COBRE is to enhance the conditions that accelerate the pace of scientific discovery, heighten research productivity and optimize competitiveness for extramural funding. The center has excelled in basic and applied research in mammalian developmental and reproductive biology, and one obvious arena which would provide a clear opportunity for growth and increased competitiveness is translational research. Over the past three years, the IBR-COBRE has pursued a primary strategic goal of developing a translational research arm of its focus by partnering with the Department of Obstetrics, Gynecology & Women's Health (Dept. Ob/Gyn). The Dept. of Ob/Gyn is one of the most successful clinical departments at the medical school, that has recently accrued more than $8 million in endowments for its academic development. The IBR's partnership with Ob/Gyn is facilitated by the appointment of the IBR-COBRE PI as the Chief of the Division of Research in the Dept. Ob/Gyn in November, 2014. He manages the $2 million Sharma Endowment designated for research in the department. Also, the Dept. of Ob/Gyn recently recruited a physician-scientist, Dr. Men-Jean Lee, who is Chief of the Division of Maternal Fetal Medicine. Dr. Lee was given lab space in the main IBR facility, facilitating collaborations between the IBR and Ob/Gyn. Two other members of the IBR, Drs. M. Ward, and Garmire, are adjunct faculty in the Dept. Ob/Gyn. One Phase II COBRE project is a clinical study that partners with Dept. Ob/Gyn examining the mechanism of increased cancer in children born to obese mothers. This partnership already resulted in an R01 examining epigenetic changes in diseased placenta. The IBR has therefore developed a strong and successful partnership with the clinical department that is closest to its focus of research. In Phase III, the center will leverage its partnership with Dept. Ob/Gyn to develop and implement a flexible Translational Research Pilot Project Program that is targeted to developing translational research projects, with the goal of developing a new arm of the center expanding its competitiveness. The program will be flexible, with two types of awards, translational research pilot projects that require collaborations between IBR and Ob/Gyn faculty, and bridging funds to assist researchers bridge funding gaps. The programs are designed to develop translational research projects, steer mature investigators through funding lapses, and to provide a flexible, and functional mechanism to assist already competitive faculty in the IBR.

项目摘要/摘要 - 转化试点项目计划 借助想法资助，生物发生研究所（IBR）蓬勃发展，从一个小的，新的 由三个教师组成的机构，到世界著名的发展和生殖生物学中心 四个不同部门的14位教职员工。 IBR-Cobre的总体目标是增强 加速科学发现速度，提高研究生产率并优化的条件 竞争性资金的竞争力。该中心在哺乳动物的基础研究和应用研究方面都非常出色 发展和生殖生物学，以及一个明显的舞台，可以为 增长和提高竞争力是翻译研究。在过去的三年中，IBR-Cobre 通过与 妇产科和妇女健康部（OB/GYN部）的产科系。 ob/gyn部门是 医学院最成功的临床部门，最近累积了超过800万美元 在其学术发展的基础上。 IBR与OB/GYN的合作关系由 任命IBR-Cobre Pi在11月的OB/Gyn系研究部负责 2014年。他管理了该部门指定的200万美元Sharma捐赠基金。另外， OB/Gyn部最近招募了一位身体科学家Men-Jean Lee博士，他是部门负责人 孕产妇胎儿医学。 Lee博士在IBR主要设施中获得了实验室空间，支持合作 在ibr和ob/gyn之间。 IBR的另外两个成员，博士。 M. Ward和Garmire是兼职教师 在OB/GYN部门。一个II期COBRE项目是一项临床研究，该研究与ob/gyn系合作 检查肥胖母亲出生的儿童增加癌症的机制。这个伙伴关系已经 导致R01检查了静置的plapeta的表观遗传变化。因此，ibr开发了 与临床部门的牢固和成功的合作伙伴关系，该部门不接受其研究重点。在阶段 III，该中心将利用其与OB/GYN部的合作伙伴关系来开发和实施灵活的翻译 研究试点项目计划，旨在开发转化研究项目，目的是 发展中心的新部门，扩大了其竞争力。该程序将是灵活的，有两种类型 奖项，翻译的研究试点项目，需要IBR和OB/Gyn教师之间的合作 并弥合资金来协助研究人员弥合资金差距。这些程序旨在开发 转化研究项目，通过资助失误引导成熟的研究人员，并提供灵活的， 和功能机制，可以协助IBR中已经具有竞争力的教师。