Laser Scanning Vibrometer

激光扫描测振仪

• 批准号: 10415806
• 负责人: Kyriacos A Athanasiou
• 金额: $ 60万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-15 至 2023-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415806
• 关键词: 3-Dimensional; Area; Biocompatible Materials; Biological; Biomechanics; California; Communities; Complex; Consultations; Engineering; Environment; Equipment; Funding; Future; Lasers; Measurement; Medicine; Minor; Operating Rooms; Procedures; Property; Research; Research Personnel; Research Project Grants; Resolution; Role; Sampling; Scanning; System; Tissue Engineering; Tissues; United States National Institutes of Health; Universities; biomechanical test; biomedical imaging; in vivo; innovation; instrument; instrumentation; interest; portability; viscoelasticity

Project Summary Rigorous biomechanical research relies on quasistatic, dynamic, and viscoelastic characterization. Although this is well accepted by the research community, experimental constraints, such as a need for minimal manipulation or a sustained in vivo environment, greatly limit the scope of biomechanical studies. Given the leading role of the University of California, Irvine (UCI) in biomechanics and mechanobiology, there is a significant need for innovative biomechanical testing instrumentation that will enable NIH-funded UCI researchers to probe many of the field’s unanswered questions beyond the capabilities of UCI’s existing equipment. In this proposal, we demonstrate the need for the purchase of a Polytec PSV-500-3D QTec Laser Scanning Vibrometer to support numerous NIH-funded research projects. The proposed Vibrometer’s ability to characterize the dynamic and viscoelastic properties of complex biological samples and biomaterials without damage is unparalleled. This proposal clearly delineates the major drawbacks of UCI’s current biomechanical testing equipment. In contrast to these instruments, the proposed Vibrometer’s advantages are extensive and include rapid contactless measurements, high resolution 3D scanning, multi-scale measurement capabilities, and portability, among others. These features are critical to maintaining highly demanding experimental conditions in complex studies, such as longitudinal characterization of cultured tissues or measurements concurrent with operating room procedures. There are no other instruments on campus or on the market that provide the proposed Vibrometer’s unique features. This proposal has been prepared by Drs. Kyriacos Athanasiou (PI), Jerry Hu, and Gabriela Espinosa in consultation with five other Major Users (Drs. Naomi Chesler, Anna Grosberg, Wendy Liu, Joshua Mauney, Ronke Olabisi) and three Minor Users (Drs. Zhongping Chen, Elliot Hui, Liangzhong Xiang). The initial set of Users represent numerous areas at the intersection of engineering and medicine, including mechanobiology, bio-microelectromechanical systems, tissue engineering and biomedical imaging. It is anticipated that interest in the proposed Vibrometer’s use will only increase, thus expanding its impact on current and future NIH-funded research at UCI.

项目摘要 严格的生物力学研究依赖于质疑，动态和粘弹性表征。虽然这个 被研究界很好地接受了实验性约束，例如需要最小的操纵 或持续的体内环境，很大程度上限制了生物力学研究的范围。鉴于 加州大学尔湾分校（UCI）在生物力学和机械生物学方面，非常需要 创新的生物力学测试仪器将使NIH资助的UCI研究人员能够探究许多 该领域的未解决问题超出了UCI现有设备的功能。在这个建议中，我们 证明需要购买Polytec PSV-500-3D QTEC激光扫描振动仪支持 NIH资助的许多研究项目。提出的振动仪表征动态和 复杂的生物样品和无损害生物材料的粘弹性是无与伦比的。这 提案显然描述了UCI当前生物力学测试设备的主要缺点。相比之下 对于这些乐器，提议的振动仪的优势是广泛的，包括快速接触 测量，高分辨率3D扫描，多尺度测量功能和可移植性 其他的。这些特征对于在复杂的研究中维持高度要求的实验条件至关重要， 例如培养组织的纵向表征或与手术室同时进行的测量 程序。校园或市场上没有其他乐器可以提供拟议的振动仪的 独特的功能。该提案是由Drs准备的。 Kyriacos Athanasiou（PI），Jerry Hu和Gabriela Espinosa与其他五个主要用户协商（Naomi Chesler博士，Anna Grosberg，Wendy Liu，Joshua Mauney，Ronke Olabisi）和三名未成年人（Zhonging Chen博士，Elliot Hui，Liangzhong Xiang）。最初 一组用户在工程和医学的交集中代表了许多领域，包括 机械生物学，生物微电机械系统，组织工程和生物医学成像。这是 预计对拟议的振动仪使用的兴趣只会增加，从而扩大其对当前的影响 以及UCI的未来NIH资助的研究。