Neurobiological pathways underlying maladaptive behaviors in youth

青少年适应不良行为背后的神经生物学途径

基本信息

批准号：
10409625
负责人：
S. Alexandra Burt
金额：
$ 7.52万
依托单位：
MICHIGAN STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-18 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10409625
关键词：
15 year old Affect Age Architecture Automobile Driving Behavior Behavioral Behavioral Mechanisms Biological Biological Process Brain Child Rearing Chronic Consequentialism Cotinine Development Disadvantaged Elements Etiology Exposure to Family Functional Magnetic Resonance Imaging Genetic Health Heritability Image Joints Lead Link Literature Mediating Mental Health Mercury Methodology Methods Michigan Modeling Nature Neighborhoods Neural Pathways Neurobiology Neurosciences Neurotoxins Outcome Pathway interactions Phenotype Positioning Attribute Poverty Process Research Rest Risk Sampling Shapes Social Processes Structure Theft Time Toxicant exposure Twin Multiple Birth Twin Studies United States Youth antisocial behavior assault base cognitive control experience genetic architecture neighborhood disadvantage neural circuit neural network neurobehavioral neuroimaging neuromechanism relating to nervous system rural area suburb vandalism

项目摘要

Decades of research have highlighted the damaging effects of disadvantaged neighborhood contexts on later health outcomes, including youth antisocial behaviors (ASB) such as assault, theft, and vandalism. Although few would now contest the behavioral sequelae of neighborhood disadvantage, the mechanism(s) driving these effects are as yet unclear. Studies linking youth ASB to alterations in the function, structure, and connectivity of affect- and cognitive control-related neural regions represent a very promising possibility, since these same neural processes appear to be altered by chronically stressful experiences including disadvantage. Although potentially quite consequential, conclusions regarding the `biological embedding of disadvantage' as a pathway to ASB remain uncertain, as we have yet to either identify the specific neural mechanisms through which neighborhood disadvantage increases youth ASB or to illuminate how disadvantage alters these particular neural pathways. The current R01 application aims to do just this. We will first identify the neural regulatory control architecture (RCA) associated with both youth ASB and neighborhood disadvantage. We will then leverage the genetically-informed nature of our one-of-a-kind at-risk, longitudinal twin study to illuminate both the genetic and environmental origins of RCA and the ways in which these influences are altered by neighborhood disadvantage, both concurrently and over time. For our final set of analyses, we will explore specific proximal processes through which neighborhood disadvantage might affect neural RCA (i.e., toxicant exposure and parenting). The proposed study is thus ideally positioned to not only identify the specific neural pathways through which neighborhood disadvantage affects youth outcomes, but also to meaningfully evaluate how neighborhood disadvantage affects the developing brain. This genetically-informed developmental neuroscience approach should fundamentally advance our understanding of both the neural pathways leading to the emergence of youth ASB, and the mechanisms through which neighborhood disadvantage undermines positive development.

数十年的研究强调了弱势社区环境的破坏性影响关于以后的健康结果，包括青少年反社会行为 (ASB)，例如攻击、盗窃和故意破坏。尽管现在很少有人会质疑邻里劣势的行为后果，驱动这些效应的机制尚不清楚。研究将青少年 ASB 与身体变化联系起来情感和认知控制相关神经区域的功能、结构和连接性代表了一种非常有希望的可能性，因为这些相同的神经过程似乎会被改变长期的压力经历，包括不利条件。尽管可能会产生相当大的影响，关于“劣势的生物嵌入”作为 ASB 途径的结论仍然存在不确定，因为我们还没有确定具体的神经机制邻里劣势会增加青少年的 ASB 或阐明劣势如何改变这些特定的神经通路。当前的 R01 应用程序旨在实现这一目标。我们将首先识别与青少年 ASB 和邻里相关的神经调节控制架构 (RCA) 劣势。然后，我们将利用我们独一无二的高危人群的遗传信息性质，纵向双胞胎研究阐明 RCA 的遗传和环境起源及其途径其中，这些影响会同时或随着时间的推移而因邻里劣势而改变。对于我们的最后一组分析，我们将探索特定的近端过程，通过该过程，邻域不利因素可能会影响神经 RCA（即毒物暴露和养育）。拟议的研究是因此，理想的定位不仅是识别邻域所通过的特定神经通路劣势会影响青少年的成果，但也可以有意义地评估邻里如何不利影响发育中的大脑。这种基于遗传的发育神经科学方法应该从根本上增进我们对导致神经通路的理解青年ASB的出现，以及邻里劣势的机制破坏积极的发展。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Understanding the effects of neighborhood disadvantage on youth psychopathology.

DOI：
10.1017/s0033291721005080
发表时间：
2023-05
期刊：
PSYCHOLOGICAL MEDICINE
影响因子：
6.9
作者：
Carroll, Sarah L.;Klump, Kelly L.;Burt, S. Alexandra
通讯作者：
Burt, S. Alexandra

Charting brain growth and aging at high spatial precision.

DOI：
10.7554/elife.72904
发表时间：
2022-02-01
期刊：
eLife
影响因子：
7.7
作者：
Rutherford S;Fraza C;Dinga R;Kia SM;Wolfers T;Zabihi M;Berthet P;Worker A;Verdi S;Andrews D;Han LK;Bayer JM;Dazzan P;McGuire P;Mocking RT;Schene A;Sripada C;Tso IF;Duval ER;Chang SE;Penninx BW;Heitzeg MM;Burt SA;Hyde LW;Amaral D;Wu Nordahl C;Andreasssen OA;Westlye LT;Zahn R;Ruhe HG;Beckmann C;Marquand AF
通讯作者：
Marquand AF

Illuminating Associations between Parenting and Deleterious Neighborhood Characteristics via an Exhaustive Modeling Approach.

DOI：
10.1111/jomf.12871
发表时间：
2023-02
期刊：
JOURNAL OF MARRIAGE AND FAMILY
影响因子：
6
作者：
Burt, S. Alexandra;Thaler, Daniel;Shewark, Elizabeth A.;Pearson, Amber L.;Anaya, Carolina;Tomlinson, Rachel C.;Neiderhiser, Jenae M.;Klump, Kelly L.;Lonstein, Joseph S.
通讯作者：
Lonstein, Joseph S.

Elucidating the role of negative parenting in the genetic v. environmental influences on adult psychopathic traits.

DOI：
10.1017/s0033291721002269
发表时间：
2023-02
期刊：
PSYCHOLOGICAL MEDICINE
影响因子：
6.9
作者：
Dotterer, Hailey L.;Vazquez, Alexandra Y.;Hyde, Luke W.;Neumann, Craig S.;Santtila, Pekka;Pezzoli, Patrizia;Johansson, Ada;Burt, S. Alexandra
通讯作者：
Burt, S. Alexandra

Associations Between Parental Psychopathic Traits, Parenting, and Adolescent Callous-Unemotional Traits.