Cancer Biology and Signaling

癌症生物学和信号转导

基本信息

批准号：
10400740
负责人：
DONG-ER ZHANG
金额：
$ 3.01万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-07-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10400740
关键词：
Abnormal Cell Affect Animal Model Attention Biochemical Biochemistry Bioinformatics Biological Cancer Biology Cancer Center Cancer Center Support Grant Cancer Detection Cancer Patient Catchment Area Cell Survival Cell model Cell physiology Cells Cellular biology Complement Cues DNA sequencing Detection Development Diagnosis Direct Costs Drug Targeting Enzymes Funding Future Genes Genetic Genomics Goals Growth Guanosine Triphosphate Phosphohydrolases Human Immune system Immunity Knowledge Liquid substance Malignant Neoplasms Metabolic Molecular Molecular Biology Molecular Target Mutation NCI-Designated Cancer Center Neoplasm Metastasis Normal Cell Oncogene Activation Oncogenic Pathway interactions Peer Review Phosphotransferases Production Publications Quality of life Regulation Reporting Research Research Personnel Schools Signal Pathway Signal Transduction Signal Transduction Pathway Solid Source Technology Therapeutic Transcription Alteration Tumor Immunity Tumor Suppressor Genes Tumor Suppressor Proteins United States National Institutes of Health Vision anticancer research cancer cell cancer immunotherapy cancer initiation cancer prevention cancer therapy cell growth cell growth regulation collaborative environment genetic regulatory protein genomic data member novel programs response structural biology success tool transcription factor treatment effect tumor tumorigenesis

项目摘要

CANCER BIOLOGY AND SIGNALING ABSTRACT The overarching goal of the Cancer Biology and Signaling Program (CBS) is to provide fundamental scientific knowledge for the molecular and cellular basis of cancer (including initiation, progression, and metastasis) and the interaction between cancer and the immune system. Scientific discoveries of CBS members are aimed to provide molecular targets for cancer detection, diagnosis, and therapy through 2 aims: 1) understand signaling pathways involved in cell growth regulation; 2) investigate the molecular mechanisms of oncogenic development and progression. For these goals, research conducted by CBS members during the current project period has made a number of major advancements on signaling pathways in cell growth control, mechanisms of oncogenes and tumor suppressors in oncogenesis, and interaction between cancer and host immune system. The central themes of CBS include 1) signal transduction and 2) cell growth, with a developing focus on immunity in tumorigenesis. Drs. Dong-Er Zhang and Kun-Liang Guan have been CBS co-leaders since 2008. They have complementary expertise (alteration of transcription of liquid cancer development and signal transduction regulating growth of solid cancer cells) and share a common vision for future success of CBS, which will continue to advance basic knowledge and provide the scientific basis for early cancer prevention, detection, and treatment. The 52 members of CBS represent 11 departments and 3 schools. In 2017, CBS members had $18.6M in cancer-relevant, peer-reviewed funding (direct costs), of which $8.3M (45%) was from NCI, $9.1M (49%) was from other NIH sources, and $1.1M (6%) was from other peer-reviewed agencies. In addition, CBS members had $1.6M in cancer-relevant, non-peer reviewed funding (direct costs) During the project period (2013-2017), members authored 669 cancer-relevant publications, of which 78 (12%) were intra-programmatic, 162 (24%) were inter-programmatic, and 190 (28%) were collaborative with investigators from other NCI- designated cancer centers.

癌症生物学和信号传导摘要癌症生物学和信号转导计划 (CBS) 的总体目标是提供基础科学癌症的分子和细胞基础知识（包括起始、进展和转移）以及癌症与免疫系统之间的相互作用。 CBS 成员的科学发现旨在通过以下两个目标为癌症检测、诊断和治疗提供分子靶标：1) 了解信号传导参与细胞生长调节的途径； 2）研究致癌发展的分子机制和进展。为了实现这些目标，CBS 成员在当前项目期间进行的研究在细胞生长控制信号通路、癌基因机制等方面取得多项重大进展和肿瘤抑制因子在肿瘤发生中的作用，以及癌症与宿主免疫系统之间的相互作用。中央 CBS 的主题包括 1) 信号转导和 2) 细胞生长，重点关注免疫肿瘤发生。博士。张冬尔和关昆亮自 2008 年起担任 CBS 联合领导人。互补的专业知识（液体癌症发展和信号转导的转录改变调节实体癌细胞的生长）并对 CBS 的未来成功拥有共同愿景，该愿景将继续提高基础知识，为早期癌症预防、检测和治疗提供科学依据治疗。 CBS的52名成员代表11个院系和3所学校。 2017 年，CBS 成员有 1860 万美元的癌症相关同行评审资金（直接成本），其中 830 万美元（45%）来自 NCI，910 万美元 (49%) 来自其他 NIH 来源，110 万美元 (6%) 来自其他同行评审机构。此外，哥伦比亚广播公司在项目期间，成员获得了 160 万美元的癌症相关、非同行评审资金（直接费用） (2013-2017)，成员撰写了 669 篇与癌症相关的出版物，其中 78 篇 (12%) 是项目内的， 162 (24%) 是跨项目的，190 (28%) 是与其他 NCI 的研究人员合作的指定的癌症中心。