Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed)

促进健康相关研究多样性的研究补充（管理补充 - 不允许进行临床试验）

• 批准号: 10400398
• 负责人: Stephania A Cormier
• 金额: $ 2.92万
• 依托单位: LOUISIANA STATE UNIV A&M COL BATON ROUGE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-22 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10400398
• 关键词: Address; Biological; Biomedical Research; Chemicals; Clinical Trials; Data; Exposure to; Free Radical Formation; Free Radicals; Goals; Grant; Health; Human; Laboratories; Laccase; Lung; Mentors; Methodology; Methods; Myron; National Institute of Environmental Health Sciences; Nature; Oxidation-Reduction; Prevention; Reproducibility; Research; Research Project Grants; STEM field; Soil; Superfund; System; Training; Training Activity; Underrepresented Minority; Work; Writing; advanced analytics; analytical method; base; cardiovascular health; career development; data sharing; lard; recruit; remediation; response; responsible research conduct; skills

Project Summary/Abstract The evidence is strong that underrepresentation of minorities in the STEM fields is a critical issue that needs to be addressed. One of the objectives of this proposal is to recruit, support, and mentor a trainee, Mr. Myron Lard, from an underrepresented background, for Project 5 of LSU Superfund Research Center – Environmentally Persistent Free Radicals (NIEHS grant #2-P42ES013648-09) through a research supplement to promote diversity in health-related research (following PA-21-071). The aim of the research at the LSU Center is to understand how environmentally persistent free radicals (EPFRs) are formed and how they impact pulmonary and cardiovascular health, as well as to develop prevention, remediation, and human health protective strategies based on fundamental physical, chemical, and biological understanding, with Project 5 focusing on the fundamental physical and chemical understanding. The project can be viewed as two components. The first component is the scientific research in which laboratory-generated EPFR systems, mimicking EPFR-containing soils, will be studied to determine if 1) EPFR formation by multiple redox centers is additive and 2) biological inputs, such as laccase, induce further EPFR formation beyond that seen in abiotic systems. The laboratory-generated EPFRs will then be studied by advanced analytical methods to gain an atomic-level understanding of EPFR formation and the nature of the formed EPFRs. Subsequently, and in conjunction with Projects 1 and 2, biological exposure to the laboratory-generated EPFRs will be performed, with the main goal of using atomic-level information to predict the nature and magnitude of the biological responses to these EPFRs. In addition to the experimental training, in the second component of this project, Mr. Lard will be mentored in scientific research presentation skills, new methodologies, methods for enhancing rigor and the reproducibility of data as well as data sharing, the Responsible Conduct of Research, grant writing, and career development. When combined, these training activities will enhance Myron's research capabilities, particularly in the field of biomedical research.

项目摘要/摘要 有证据表明，茎场中少数族裔的人数不足是一个 需要解决的关键问题。该提议的目标之一是 来自人为不足的招募，支持和指导学员Myron Lard先生 背景，用于LSU超级基金研究中心的项目5 - 环境 通过一项研究 补充以促进与健康相关研究的多样性（PA-​​21-071之后）。这 LSU中心研究的目的是了解环境持久性如何 自由基（EPFR）形成以及它们如何影响肺和心血管 健康以及预防，补救和人类健康保护 基于基本物理，化学和生物学理解的策略， 项目5专注于基本的物理和化学理解。项目 可以看作是两个组件。第一个组成部分是科学研究 实验室生成的EPFR系统，模仿含EPFR的土壤，将研究 确定1）由多个氧化还原中心形成EPFR是否是加性的，2）生物学 输入（例如漆酶）诱导进一步的EPFR形成，超出了非生物的形成 系统。然后，实验室生成的EPFR将通过高级分析进行研究 获得对EPFR形成和本质的原子水平理解的方法 形成的EPFR。随后，与项目1和2结合生物学 将执行暴露于实验室生成的EPFR，主要目标是 使用原子级信息来预测生物学的性质和幅度 对这些EPFR的响应。除了实验训练之外，第二 该项目的组成部分，Lard先生将在科学研究介绍中考虑 技能，新方法，增强严谨性的方法以及数据的可重复性 以及数据共享，负责任的研究，授予写作和职业的行为 发展。合并后，这些培训活动将增强Myron的研究 能力，特别是在生物医学研究领域。