LSU Superfund Research Center - Environmentally Persistent Free Radicals

路易斯安那州立大学超级基金研究中心 - 环境持久性自由基

基本信息

批准号：
10575424
负责人：
Stephania A Cormier
金额：
$ 4.72万
依托单位：
LOUISIANA STATE UNIV A&M COL BATON ROUGE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-22 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10575424
关键词：
Address Adult Advisory Committees Advocacy Affect Age Archives Area Asthma Attenuated Biological Biological Markers Birth Cardiac Cardiopulmonary Cardiovascular Diseases Cardiovascular system Chemical Engineering Chemicals Chemistry Child Childhood Childhood Asthma Communication Communities Copper Data Data Analyses Degradation Pathway Dioxins Ensure Environment Environmental Health Environmental Monitoring Evaluation Exposure to F2-Isoprostanes Factor Analysis Failure Fostering Free Radical Formation Free Radicals Free Will Functional disorder Funding Goals Government Agencies Hazardous Substances Hazardous Waste Health Health Policy House Dust Human Hydroxyl Radical Industry Inhalation Exposure Inhalation Toxicology Link Location Lung Metabolic Metals Methods Organic Chemicals Organism Outcome Oxidative Stress Particulate Matter Persons Physics Pneumonia Population Prevention Process Protocols documentation Public Health Reagent Regulation Research Research Personnel Research Project Grants Resources Risk Risk Assessment Role Route Sampling Services Silicon Dioxide Site Superfund Surface System Technology Toxic effect Training Transition Elements Wheezing Work base cohort community engagement data management detection method environmental particulate experience exposed human population improved in vivo interdisciplinary approach iron oxide metal oxide mouse model oxidative damage particle pollutant prevent programs remediation respiratory respiratory health sensor success superfund site technique development treatment site wasting web portal

项目摘要

Project Summary/Abstract: Overall Nearly 53 million people (17% of the US population; 18% of children <5 yrs) live within 3 miles of a Superfund remediation site. Superfund sites contain a wide variety of pollutants, including organic chemicals, metals, carbo- naceous material and silica. Although each of these components is capable of damage to organisms, their poten- tial to combine into unique hazardous agents has been understudied. Interestingly, when these agents are pre- sent together, particularly during thermal remediation, they combine to form particulate matter (PM) with chemi- sorbed free radicals that persist in the environment and yet are biologically active. We call these pollutant-particle systems environmentally persistent free radicals (EPFRs). EPFRs are produced during thermal treatment of haz- ardous wastes and nearly 30% of all Superfund sites (excluding groundwater) are remediated by thermal treat- ment. EPFR concentrations near Superfund sites range from 1x1018-4x1019 EPFRs/g (spins/g) of PM. This sug- gests a vast number of US residents are exposed to PM containing EPFRs. LSU Superfund Research Center researchers have shown that these EPFRs 1) induce cardiac and pulmonary dysfunction in the exposed host, 2) are associated with current wheeze in children if present in household dust, and 3) are intermediates in the for- mation of new pollutants such as dioxins. Our Center now seeks to understand how EPFRs induce pulmo- nary/cardiovascular dysfunction and how to attenuate EPFR formation, facilitate EPFR decay, and limit exposure to EPFRs, with the ultimate goal of improving human health and the environment. We will determine how EPFRs are formed, stabilized, and decay and how they catalytically cycle to produce hydroxyl radicals. This will be done using a suite of advanced surface and chemical analyses. Since the airway is a major site of entry of environ- mental PM, we will demonstrate a link between EPFR exposure and poor respiratory health in children using es- tablished community-based birth cohorts. We will explore mechanisms of EPFR-induced asthma and cardiovas- cular disease using mouse models exposed by inhalation. Support cores (Administration, Data Management & Analysis, Community Engagement, Research Experience and Training Coordination, Materials, and Inhalation Toxicology) will provide essential, centralized reagents/services and technological resources allowing for precision of data and economy of effort, and foster interdisciplinary activities. To ensure success, experts in these respective fields were brought together as an External Advisory Committee to advise this Center. The chemistry and physics of EPFRs, let alone their health impacts, are poorly understood, and an interdisciplinary approach is required to address the critical research areas.

项目摘要/摘要：总体近5300万人（占美国人口的17％； <5岁的儿童中的18％）居住在超级基金3英里以内修复地点。超级基金地点包含多种污染物，包括有机化学品，金属，碳水化合物 - 含材料和二氧化硅。尽管这些成分中的每一个都能够损害生物，但它们的潜在将其结合成独特的危险药物已经进行了研究。有趣的是，当这些试剂是预先的一起发送，特别是在热补救期间，它们结合在一起以形成颗粒物（PM）吸附的自由基在环境中持续存在，但具有生物学活跃。我们称这些污染物粒子系统在环境上持久的自由基（EPFR）。 EPFR是在危险热处理过程中产生的热疗法（不包括地下水）的热量废物和将近30％精神。超级基金位点附近的EPFR浓度范围为PM的1x1018-4x1019 EPFRS/g（Spins/g）。这个sug- 盖斯特（Gests）大量的我们居民暴露于包含EPFR的PM。 LSU超级基金研究中心研究人员表明，这些EPFR 1）在暴露宿主中诱导心脏和肺功能障碍，2）如果家用灰尘中存在，与当前儿童的喘息有关，而3）则是中间体新的污染物（例如二恶英）的元素。我们的中心现在试图了解EPFR如何诱导Pulmo- Nary/心血管功能障碍以及如何衰减EPFR组，促进EPFR衰减并限制暴露致EPFR，最终的目标是改善人类健康和环境。我们将确定如何EPFR 形成，稳定和衰减，以及它们如何催化循环以产生羟基自由基。这将完成使用一套晚期表面和化学分析。由于气道是环境进入的主要地点心理PM，我们将展示使用ES-儿童的EPFR暴露与呼吸不良之间的联系使基于社区的出生队列。我们将探索EPFR诱导的哮喘和心脏的机制使用吸入暴露的小鼠模型。支持核心（管理，数据管理和分析，社区参与，研究经验和培训协调，材料和吸入毒理学）将提供基本的，集中的试剂/服务和技术资源，以便数据和努力经济的精度，以及促进跨学科活动。为了确保成功，专家各自的领域被汇集为外部咨询委员会，以建议该中心。化学 EPFR的物理学，更不用说它们的健康影响了，人们对此很了解，并且是跨学科的方法需要解决关键研究领域。