EPIGENETIC-GENETIC-MENTAL HEALTH CASCADE BASED PERSONALISED PREVENTION OF NONCOMMUNICABLE DISEASE IN ADOLESCENTS DIAGNOSED WITH AUTISM (ETHEREAL)

基于表观遗传-遗传-心理健康级联的个性化预防自闭症青少年非传染性疾病（ETHEREAL）

• 批准号: 10063676
• 金额: $ 45.3万
• 依托单位: MICROLINK PC (UK) LIMITED
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10063676
• 关键词: EPIGENETIC; GENETIC; MENTAL; HEALTH; CASCADE

Five Noncommunicable Diseases (NCD) – diabetes, cardiovascular disease, cancer, chronic respiratory disease and Mental Health Disorders (MHD) – account for 86% deaths and 77% disease burden in the WHO Europe region. Of these five NCDs, MHD is unique as it has a complex bi-directional relationship with the other four major NCDs, meaning that, on one hand, it could be the initiator of the other NCDs, or other NCDs could lead to MHD which, in turn, can further aggravate the primary NCD leading to a vicious circle. Recent research identified MHD as the highest ranked NCD in adolescent population. A specific group in this population that is 3 - 6 times more vulnerable for developing MHD and subsequent NCD is the adolescents diagnosed with Autism Spectrum Disorders (ASD). There is no Evidence Based Intervention (EBI) for preventing MHD in an ASD adolescent since 1) the major risk factors are in-grained in their biological process and 2) they present with multiple MHD comorbidity. Personalisation is the key to prevent their already vulnerable mental states making transition to an MHD - "which" EBI is appropriate for "which" ASD adolescent and "how" to choose it - an unsolved question. Because of their neurobiological characteristics, personalisation must be done at biological level. Recent research showed how the environmental factors can alter gene expressions that leads to an MHD through Epigenetic-Genetic/metabolomicMental health (EGM) process. Using quantitative modelling of this process, ETHREAL will develop a personalised, flexible, single service delivery model that will empower an ASD adolescent to self-control their environmental factors while seamlessly accessing the community care services to prevent their mental health making transition to an MHD - a unique solution for sustainable prevention of MHD and subsequent NCDs in this population. Without loss of generality, the proposed solution could be adapted to prevent MHD in wider adolescent population.

五种非传染性疾病 (NCD)——糖尿病、心血管疾病、癌症、慢性呼吸道疾病和精神健康障碍 (MHD)——造成世界卫生组织欧洲地区 86% 的死亡和 77% 的疾病负担，在这五种非传染性疾病中，MHD 是独一无二的。它与其他四种主要非传染性疾病具有复杂的双向关系，这意味着，一方面，它可能是其他非传染性疾病的始作俑者，或者其他非传染性疾病可能导致 MHD，而 MHD 反过来，最近的研究发现，MHD 是青少年人群中排名最高的非传染性疾病，而被诊断为患有 MHD 和后续非传染性疾病的青少年是该人群的 3 - 6 倍。自闭症谱系障碍 (ASD)。没有基于证据的干预措施 (EBI) 可以预防 ASD 青少年的 MHD，因为 1) 主要危险因素是其生物过程中根深蒂固的，2) 它们存在个性化是防止他们本已脆弱的心理状态过渡到 MHD 的关键——“哪种”EBI 适合“哪种”自闭症青少年以及“如何”选择它——这是一个尚未解决的问题。 ，个性化必须在生物学水平上进行。最近的研究表明，环境因素如何通过表观遗传/代谢心理健康（EGM）过程改变基因表达，从而导致 MHD。在此过程中，ETHREAL 将开发一种个性化、灵活、单一的服务提供模式，使 ASD 青少年能够自我控制他们的环境因素，同时无缝地获得社区护理服务，以防止他们的心理健康向 MHD 过渡——这是可持续发展的独特解决方案在不失一般性的情况下，所提出的解决方案可以适用于在更广泛的青少年人群中预防 MHD。