Conduct of studies to evaluate the toxic and carcinogenic potential of naturally occurring asbestos and related mineral fibers in laboratory animals

进行研究以评估天然石棉和相关矿物纤维对实验动物的毒性和致癌潜力

• 批准号: 10388060
• 负责人: BARNEY SPARROW
• 金额: $ 539.33万
• 依托单位: BATTELLE MEMORIAL INSTITU
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2022-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10388060
• 关键词: Adverse effects; Amphiboles; Asbestos; Chemicals; Chronic; Data; Development; Ensure; Environmental Exposure; Exposure to; Fiber; Goals; Hazard Identification; Hazardous Chemicals; Health; Histopathology; Human; Inhalation; Inhalation Exposure; Laboratory Animals; Lung; Methods; Mineral Fibers; Mission; National Toxicology Program; Nose; Phase; Preparation; Rattus; Reporting; Research Design; Risk Assessment; Risk Factors; Source; System; Tissues; Toxic effect; Toxicity Tests; Toxicology; Work; carcinogenicity; design; disorder prevention; method development; public health research; sound

The goal of this project is to provide support of the Division of the National Toxicology Program (DNTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of method development work to support the design and conduct of toxicity and carcinogenicity studies of multiple, diverse mineral fibers in rats, following exposure by nose-only inhalation. There are concerns over sources of these mineral fibers across the USA, and there are questions surrounding similarities among relative potencies. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of naturally occurring asbestos and related mineral fibers in rats and ultimately supports the mission and goals of DNTP and risk assessment activities of other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to naturally occurring asbestos and related mineral fibers. Keywords: toxicity, carcinogenicity, asbestos, inhalation, fiber, lung

该项目的目的是提供支持国家毒理学计划（DNTP）危害识别活动，该危害识别活动针对预防疾病或由环境暴露于化学或物理药物引起的不良影响。毒性测试是公共卫生研究的重要方面，它有助于识别对人类健康有害的化学物质。需要正确进行毒理学研究，以确保所得数据可靠。该项目涉及方法开发工作，以支持大鼠多种多样的矿物纤维的毒性和致癌性研究，在仅通过鼻子吸入。人们担心美国各地这些矿物纤维的来源，并且在相对效力之间存在相似之处的问题。该项目的数据将用于开发声音，科学结论，内容涉及大鼠天然石棉和相关矿物纤维的潜在毒性和致癌性，并最终支持其他联邦机构的DNTP和风险评估活动的使命和目标。此外，可以充分了解公众关于暴露于自然存在的石棉和相关矿物纤维引起的危险因素。 关键字：毒性，致癌性，石棉，吸入，纤维，肺