Production of TempOSeq data for the DrugMatrix reference library

为 DrugMatrix 参考库生成 TempOSeq 数据

• 批准号: 10710454
• 负责人: BARNEY SPARROW
• 金额: $ 110.04万
• 依托单位: BATTELLE MEMORIAL INSTITU
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-26 至 2023-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10710454
• 关键词: Data; Databases; Libraries; Modernization; Pharmaceutical Preparations; Production; RNA; Rattus; Residual state; Resources; Scientist; Technology; Testing; Tissues; Toxicogenomics; Toxicology; transcriptome; transcriptomics

The Drug Matrix reference library is a toxicogenomic reference resource of scientists in the field of toxicology. THe database is comprised of transcriptomic data from rats treated with over 600 test agents. The transcriptomic data in the original library was largely comprised of Affymetrix microarray data; as other technologies have taken over in the field, and in use by the Division of Translational Toxicology there was a desire by the division to utilize residual tissue and isolated RNA from the rat studies and produce S1500+ and whole transcriptome TempOSeq data to add to the database.

药物基质参考文献是毒理学领域的科学家的毒性参考资源。该数据库由来自600多种测试剂治疗的大鼠的转录组数据组成。原始库中的转录组数据主要由Affymetrix微阵列数据组成。正如其他技术在该领域接管的那样，在翻译毒理学的划分时，该部门希望利用残留组织和从大鼠研究中分离的RNA，并产生S1500+和整个转录组Temposeq数据以添加到数据库中。