SUPPORT FOR THE CONDUCT OF STUDIES TO EVALUATE THE TOXICOLOGIC POTENTIAL OF Garcinia cambogia FOR THE NTP

支持开展研究以评估藤黄果对 NTP 的毒理学潜力

• 批准号: 10213574
• 负责人: BARNEY SPARROW
• 金额: $ 70万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-26 至 2020-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10213574
• 关键词: Amniotic Fluid; Body Weight decreased; Bolus Infusion; Cytology; Data; Desire for food; Diet; Dose; Ephedra; Evaluation; Fetus; Food; Fruit; Garcinia; Garcinia cambogia; Laboratories; Lipids; Mus; Oral; Persons; Plasma; Pregnancy; Rattus; Regimen; Reporting; Route; Sampling; Sperm Count Procedure; Sperm Motility; Testing; Thermogenesis; Time; Tissues; Toxic effect; Toxicology; Vagina; base; dietary supplements; exposed human population; fat burning; sperm analysis

Garcinia cambogia extract (GCE) was nominated for testing based on its widespread use as a diet aid and a lack of adequate toxicity data. It was the 6th best-selling dietary supplement in the U.S. in 2016 (Smith et al., 2017). GCE is prepared from the rind of Garcinia gummi-gutta (renamed from Garcinia cambogia) fruit and products containing GCE are marketed as ephedra-free diet aids. Purported effects of GCE include appetite suppression, inhibition of lipid synthesis, and fat burning via thermogenesis. Typically, the use of GCE as a weight loss supplement is via caplets taken prior to meals three times per day, resulting in a total dose of approximately 4,500-6,000 mg/day (~75-100 mg/kg/day for a 60 kg person). Due to the recommended regimen of GCE (3 times daily with food) as well as the traditional use of Garcinia as an ingredient in Indian cuisine, dosed-feed was selected as the route of administration, as opposed to oral gavage, which has typically been employed with herbal test articles and delivers a daily bolus dose. During the current year, the draft laboratory reports of the study were prepared and reviewed, and the reports are currently being finalized

藤黄果提取物（GCE）被提名进行测试是因为其广泛用作饮食辅助剂且缺乏足够的毒性数据。它是 2016 年美国第六畅销膳食补充剂（Smith 等，2017）。 GCE 由藤黄果果皮制成，含有 GCE 的产品作为不含麻黄的减肥助剂进行销售。 GCE 据称的作用包括抑制食欲、抑制脂质合成以及通过生热作用燃烧脂肪。通常，GCE 作为减肥补充剂的使用方式是每天 3 次饭前服用胶囊，总剂量约为 4,500-6,000 毫克/天（60 公斤体重者约为 75-100 毫克/公斤/天）人）。由于推荐的 GCE 方案（每天 3 次，与食物一起服用）以及传统上使用藤黄作为印度美食的成分，选择定量饲料作为给药途径，而不是通常采用的口服强饲法。与草药测试品一起使用并提供每日推注剂量。今年，该研究的实验室报告草稿已完成并经过审查，目前报告正在定稿中