Support for the CONDUCT OF STUDIES TO EVALUATE THE IMPACT OF GENETIC BACKGROUND AND POTENTIAL TREATMENTS ON SEVERE SARS-CoV-2 INDUCED PNEUMONIA FOR THE NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIEN

支持国家环境卫生科学研究所开展研究，评估遗传背景和潜在治疗方法对严重 SARS-CoV-2 引起的肺炎的影响

• 批准号: 10281194
• 负责人: BARNEY SPARROW
• 金额: $ 15万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-26 至 2020-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10281194
• 关键词: 2019-nCoV; Adult Respiratory Distress Syndrome; Affect; COVID-19; Complication; Disease; Elderly; Environmental Health; Genetic; High Prevalence; Individual; Institutes; Intensive Care; Lung; Medical; Mus; Patients; Pneumonia; Respiratory Failure; novel

COVID19 is a novel zoonosis which has the potential for severe complications. Approximately 20% of affected individuals develop severe pneumonia progressing to acute respiratory distress syndrome (ARDS). Complication rates increase with advanced age, and 6-15% of patients over 70 years die due to COVID19. Severe COVID19 is manifesting primarily as ARDS and respiratory failure, leading to high prevalence of prolonged intensive care utilization, and thus to overwhelmed medical facilities. Currently there is no proven treatment for COVID19 severe disease.

Covid19是一种新型的人畜共患病，具有严重并发症的潜力。大约20％的受影响的个体发生严重的肺炎，发展为急性呼吸窘迫综合征（ARDS）。并发症发生率随年龄的增长而增加，而由于1909年，在70岁以上的患者中，有6-15％的患者发生。严重的COVID19主要表现为ARDS和呼吸衰竭，导致重症监护病的长期患病率很高，从而导致医疗设施不堪重负。目前尚无对COVID19严重疾病的良好治疗方法。