Resource Core

资源核心

• 批准号: 10380052
• 负责人: Alice F Tarantal
• 金额: $ 130.8万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-15 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10380052
• 关键词: Adult; Animals; Biological Assay; Blood; Blood specimen; California; Callithrix; Caring; Cells; DNA; Data; Dideoxy Chain Termination DNA Sequencing; Emergency Situation; Ensure; Evaluation; Funding; Genes; Genomics; Genotype; Goals; Infrastructure; Macaca mulatta; Methods; Primates; Procedures; Production; Protocols documentation; Quarantine; Readiness; Reporter; Reporter Genes; Research; Research Personnel; Research Project Grants; Resources; Rhesus; Safety; Sampling; Security Measures; Services; Site; Specificity; Specimen; System; Technology; Testing; Time; Transgenes; Translations; adaptive immunity; age group; base; biobank; experience; genome editing; genome sequencing; hazard; human disease; multidisciplinary; nonhuman primate; programs; quality assurance; reproductive; somatic cell gene editing; tool

Resource Core PROJECT SUMMARY / ABSTRACT The overarching goal of the Resource Core is to provide nonhuman primates in the quantity necessary to meet the needs of Somatic Cell Genome Editing (SCGE) awardees. The Resource Core is embedded within the established, comprehensive infrastructure provided by the California National Primate Research Center. Rhesus macaques and marmosets will be available for SCGE investigator studies to be conducted in the Genome Editing Testing Core and in order to generate data on efficiency, specificity, and safety of the technologies developed. The Resource Core will accelerate translation of genome editing technologies from studies in nonhuman primates into treatments for human diseases through the following Specific Aims: (1) Provide nonhuman primates and related capabilities for investigator projects, and (2) Receive, breed, and maintain reporter nonhuman primates. The Resource Core will provide at least 100 animals per year, which will include wild-type and reporter rhesus and marmosets. The Resource Core will ensure investigators have the quality and quantity of nonhuman primates necessary to meet their needs both through the provision of currently available animals (wild-type), and through procurement and expansion of reporter strains that will be provided to the Nonhuman Primate Testing Center from the SCGE Large Animal Production investigators. Paired with a robust Coordination Component and the Genome Editing Testing Core, and within the context of the infrastructure of the UC Davis California National Primate Research Center, the Resource Core will deliver the animals needed to comprehensively assess the promise of new genome editing technologies developed by SCGE awardees.

资源核心 项目概要/摘要 资源核心的总体目标是提供必要数量的非人类灵长类动物 满足体细胞基因组编辑 (SCGE) 获奖者的需求。资源核心嵌入在 由加州国家灵长类动物研究中心提供的成熟、全面的基础设施。 恒河猴和狨猴将可用于 SCGE 研究者研究，该研究将在 基因组编辑测试核心，以便生成有关效率、特异性和安全性的数据 技术开发。资源核心将加速基因组编辑技术的转化 通过以下具体目标对非人类灵长类动物进行人类疾病治疗研究：(1) 为研究者项目提供非人类灵长类动物和相关能力，以及 (2) 接收、繁殖和 维持记者非人类灵长类动物。资源核心每年将提供至少 100 只动物，这将 包括野生型和报告型恒河猴和狨猴。资源核心将确保调查人员拥有 通过提供满足其需求所需的非人类灵长类动物的质量和数量 目前可用的动物（野生型），并通过采购和扩大报告菌株 由 SCGE 大型动物生产调查员提供给非人类灵长类动物测试中心。 与强大的协调组件和基因组编辑测试核心配对，并在 加州大学戴维斯分校加州国家灵长类研究中心的基础设施，资源核心将提供 动物需要全面评估新基因组编辑技术的前景 SCGE 获奖者。