Drug Discovery in Infectious Disease Training

传染病培训中的药物发现

• 批准号: 10380751
• 负责人: Robert Virgil Stahelin
• 金额: $ 20.74万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-12 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10380751
• 关键词: Communicable Diseases; Training; drug discovery

Project Summary While treatments for eradicating some infectious diseases have been successful, there is still a large gap in the treatment of infections caused by bacteria, viruses, fungi and parasites, in particular as drug resistance continues to grow as a problem. To address this evolving issue, scientists are needed who are trained to understand how pathogens interact with the host, in order to better uncover opportunities and strategies for drug discovery. This training program’s goal is to address this need by providing qualified graduate students with broad training in infectious diseases and drug discovery, complemented by professional development opportunities, that prepares them for a long productive career in infectious disease related research. The training program includes 21 faculty members from 6 departments across 4 different colleges at Purdue University. These faculty members have diverse and complementary research interests in infectious disease, drug discovery and drug delivery, structural biology, and molecular biology. All of these faculty members are part of the Purdue Institute of Inflammation, Immunology and Infectious Disease and the Purdue Institute for Drug Discovery. These institutes bring faculty and trainees together through shared research space, a seminar series, journal clubs, and social events, resulting in a unique and supportive training environment for the “Drug Discovery in Infectious Disease Training” program. In this program, students will develop expertise both in infectious disease and in drug discovery. Specifically, trainees will take a course focused on: 1) infectious diseases and drug discovery and 2) biological membranes (a common theme of pathogen entry, exit and replication). To promote responsible, rigorous and reproducible research practices, students will complete courses in statistical analysis and the responsible conduct in research. To develop written communication skills, trainees also will take a grant-writing course, where they participate in a collaborative, active learning environment to gain feedback on the development of an NIH F31 style proposal. Additional training activities include participating in a seminar series, attending regional/national scientific meetings, and completing a capstone project in the area of drug discovery in infectious disease. In completing this semester-long capstone project, trainees will build teamwork, critical thinking and data analysis skills, all while working in the context of drug discovery and infectious disease. The capstone project will be complemented with networking and learning opportunities with industrial partners who are developing new drugs for infectious diseases. Further, fellows have the opportunity to engage in entrepreneurial training, an important aspect of academic drug discovery. Using a jointly developed Individual Development Plan, the trainees and mentors will create a training plan that is tailored towards the students’ training needs and career goals. In the end, the training program will have helped students work towards their desired career goals, while also developing a workforce with a unique skillset for addressing the challenges of discovering therapies for infectious disease. !

项目摘要 虽然消除某些传染病的治疗方法已经成功，但仍有很大的差距 通过细菌，病毒，真菌和寄生虫引起的感染治疗，特别是随着耐药性的继续 成长为一个问题。为了解决这个不断发展的问题，需要经过培训的科学家来了解如何 病原体与宿主相互作用，以更好地发现药物发现的机会和策略。这 培训计划的目标是通过为合格的研究生提供广泛的培训来满足这一需求 由专业发展机会完成的传染病和药物发现 他们从事与传染病相关的研究的长期生产生涯。培训计划包括21位教职员工 来自普渡大学4个不同学院的6个系的成员。这些教职员工有 潜水员和对传染病，药物发现和药物的完整研究兴趣，结构性 生物学和分子生物学。所有这些教职员工都是普渡大学炎症研究所的一部分， 免疫学和传染病和普渡大学药物发现研究所。这些机构带来教师 通过共享的研究空间，开创性系列，期刊俱乐部和社交活动，一起学员，一起 为“传染病训练中的药物发现”带来了独特而支持的培训环境 程序。在该计划中，学生将在传染病和药物发现方面发展专业知识。 具体来说，学员将参加一门关注的课程：1）传染病和药物发现以及2）生物学 膜（病原体进入，出口和复制的共同主题）。促进负责任，严格和 可重复的研究实践，学生将完成统计分析的课程和负责任的课程 研究中的行为。为了发展书面沟通技巧，学员还将参加赠款课程， 他们参与协作，积极学习的环境，以获取有关开发的反馈 NIH F31样式建议。其他培训活动包括参加开创性系列赛，参加 区域/国家科学会议，并在传染病中完成了毒品发现领域的顶峰项目 疾病。在完成这个学期的盖石项目时，学员将建立团队合作，批判性思维和 数据分析技能，都是在药物发现和传染病的背景下工作的过程。顶峰 项目将通过与工业合作伙伴的网络和学习机会完成 为传染病开发新药。此外，研究员有机会从事企业家精神 培训，学术药物发现的重要方面。使用共同制定的个人发展计划， 学员和导师将制定一个培训计划，该计划针对学生的培训需求和 职业目标。最后，培训计划将帮助学生努力实现他们所需的职业目标， 同时还开发具有独特技能的劳动力，以应对发现疗法的挑战 用于传染病。 呢