Center for Targeted Therapeutics

靶向治疗中心

基本信息

批准号：
10372263
负责人：
IGOR B RONINSON
金额：
$ 37.25万
依托单位：
UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-10 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10372263
关键词：
Address Alzheimer&apos s Disease Applications Grants Area Automobile Driving Award Biology Career Mobility Cellular biology Centers of Research Excellence Chemicals Collaborations Complement Core Facility Databases Development Developmental Biology Disease Drug Compounding Drug Design Economic Development Education Educational workshop Environment Equipment Faculty Financial Support Flow Cytometry Fostering Friends Funding Future Goals Grant Interdisciplinary Study Laboratories Malignant Neoplasms Medical Mentors Microscopy Mission Molecular Target Paper Pharmaceutical Preparations Pharmacotherapy Phase Pilot Projects Play Process Public Health Publishing Reporting Research Research Infrastructure Research Personnel Research Project Grants Research Support Resource Sharing Resources Scientist Senior Scientist Services Small Business Innovation Research Grant Small Business Technology Transfer Research South Carolina Structure Talents Technology Therapeutic Therapeutic Human Experimentation Training United States National Institutes of Health Universities Vision Work cancer genomics career development cellular targeting college common treatment drug discovery drug synthesis faculty mentor functional genomics high risk infrastructure development instrumentation interest meetings member multidisciplinary new therapeutic target next generation operation programs prototype recruit research and development senior faculty success targeted treatment tenure track

项目摘要

ABSTRACT The principal Phase II goal of the COBRE Center for Targeted Therapeutics (CTT) is to conduct vital research oriented at identifying novel drug targets and discovering new targeted drugs, while enhancing the career development and research competitiveness of Center investigators. Targeted therapeutics is a broad term for research that seeks to develop new and more effective classes of drugs against various diseases, by selectively aiming these drugs at molecular and cellular targets that play a key role in the disease. The area of Targeted Therapeutics has been chosen because of its societal impact, the emergence of common technologies driving therapeutics research in different disease areas, and the presence of a critical core of senior faculty with broad acumen and trans-disciplinary vision in Targeted Therapeutics at USC. During Phase I, junior investigators leading CTT research projects (target PIs) were awarded five R01s and several smaller grants, and pilot project recipients received two R01s and several other grants, for a total of close to $14 million. Four target PIs received promotion and tenure and almost 50 published papers acknowledged COBRE support. Three resource cores established by the CTT provided services to 64 different laboratories and organized training workshops and a new graduate course. To build upon the success of Phase I, we will pursue the following Specific Aims. Aim 1. Support high-impact research projects and assist junior scientists in Targeted Therapeutics in their professional development and competitiveness for NIH grants, in a collaborative and nurturing environment. Target junior faculty members include four highly promising scientists, each of whom will be mentored by two senior scientists with different areas of expertise relevant to their research. Aim 2. Establish sustainable research infrastructure through the further development of strategic Cores for Targeted Therapeutics research. The Center supports research cores in Functional Genomics, Drug Design and Synthesis, and Microscopy and Flow Cytometry. These cores will provide both specialized services and intellectual scientific support. Aim 3. Assure long-term development of the CTT by broadening collaborative networking, fostering continuous recruitment, supporting new faculty in Targeted Therapeutics, and supporting pilot research projects, with an emphasis on drug discovery and preparation for multi-investigator and SBIR/STTR grant applications. CTT will conduct regular meetings and seminars and promote external collaborations. CTT will participate in the recruitment of five new junior faculty members to USC and will continue working with the “graduated” target faculty, assuring that they continue to make important discoveries and win grants. Continued success of the CTT will make an impact on the public health, scientific education and economic development of the State.

抽象的索布雷靶向治疗中心（CTT）的主要阶段目标是进行重要研究旨在识别新型药物靶标并发现新的靶向药物，同时增强职业生涯中心研究人员的发展和研究竞争力。有针对性的治疗是一个广义的术语试图通过有选择性地开发针对各种疾病的新的，更有效的药物的研究将这些药物针对在疾病中起关键作用的分子和细胞靶标。目标区域由于其社会影响，驱动的常见技术的出现，因此选择了治疗剂在不同疾病领域的治疗研究，以及具有广泛的高级教师的关键核心在南加州大学有针对性治疗的敏锐度和跨学科视野。在第一阶段，初级调查员领先的CTT研究项目（Target PI）被授予五个R01和几个较小的赠款，并进行了试点项目接收者获得了两个R01和其他几项赠款，总计近1400万美元。收到四个目标PI 晋升和任期以及近50篇发表的论文公认了毛茸茸的支持。三个资源核心由CTT建立的服务为64个不同的实验室和有组织的培训研讨会提供了服务新的研究生课程。为了建立第一阶段的成功，我们将追求以下特定目标。目标1。支持高影响力的研究项目，并协助初级科学家进行有针对性的治疗剂在协作和培养的环境中，NIH赠款的专业发展和竞争力。目标初级教职员工包括四位高度有前途的科学家，每个科学家将由两个人审议具有不同专家领域的高级科学家与他们的研究有关。目标2。通过进一步发展战略核心来建立可持续的研究基础设施有针对性的治疗研究。该中心支持功能基因组学，药物设计和合成，显微镜和流式细胞仪。这些核心将提供专业服务和智力科学支持。目的3。通过扩大协作网络，促进继续进行CTT的长期开发招聘，支持有针对性治疗的新教师，并支持试点研究项目重点是针对多入侵器和SBIR/STTR赠款应用的药物发现和准备。 CTT会进行定期会议和半私元，并促进外部合作。 CTT将参加招募五名新的初级教师到南加州大学，并将继续与“级”目标合作教师确保他们继续进行重要的发现并赢得赠款。 CTT的持续成功将对国家的公共卫生，科学教育和经济发展产生影响。