The integrated Translational Health Research Institute of Virginia (iTHRIV): Using Data to Improve Health

弗吉尼亚综合转化健康研究所 (iTHRIV)：利用数据改善健康

• 批准号: 10347172
• 负责人: Donald E Brown
• 金额: $ 380.04万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-27 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10347172
• 关键词: Achievement; Algorithms; Clinical; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Communication; Communities; Data; Data Analyses; Data Analytics; Data Commons; Data Science; Data Scientist; Data Set; Ethics; Foundations; Funding; Geographic Locations; Goals; Health; Health system; Healthcare; Human; Informatics; Infrastructure; Institutes; Institution; Insurance Carriers; Intervention; Learning; Licensing; Location; Longevity; Methods; Mission; Patients; Personal Satisfaction; Persons; Phase; Population; Privatization; Process; Reproducibility; Research; Research Activity; Research Infrastructure; Research Institute; Research Methodology; Research Personnel; Resources; Rural; Rural Population; Science; Scientist; Secure; Services; Site; Source; Special Population; Speed; System; Technology; Therapeutic; Thinness; Training; Training Support; Translational Research; United States National Institutes of Health; Universities; Urban Population; Virginia; Workforce Development; base; career development; data access; data modeling; data sharing; design; health data; implementation framework; improved; informatics infrastructure; innovation; mHealth; member; mobile application; models and simulation; multidisciplinary; next generation; novel; open data; personalized approach; programs; sharing platform; system architecture; telehealth; tool; translational scientist; wearable device

The integrated Translational Health Research Institute of Virginia (iTHRIV) program is a collaboration of public and private institutions across the Commonwealth of Virginia that brings team science, innovation, and a commitment to train the next generation of clinical and translational researchers. Our three iTHRIV partners include University of Virginia (Central VA), Virginia Tech Carilion (Southwestern VA) and Inova Health Systems (Northern VA). Our two iTHRIV affiliates are the Center for Open Science and the Licensing and Ventures Group in Charlottesville. A particular strength of iTHRIV lies in integrating data science approaches through all aspects of clinical translational research in order to speed discovery and improve the health of our communities. iTHRIV has a central tenant that serves as the organizing principle: health care solutions are hidden in underutilized data. Our overall goal is to deepen the iTHRIV infrastructure to support clinical translational research to benefit the diverse rural and urban populations that iTHRIV member clinicians serve. The unified approach across the components of this CTSA application is to integrate data and data analytics to accelerate and streamline scientific workflows for clinical trials, innovative therapeutic advancements, and the creation of more personalized approaches to healthcare. Data science is a particular strength of our team and will allow us to transform our cross-state informatics infrastructure by creating The Commons, a scalable research hosting platform shared by iTHRIV partners that will serve as the foundation for our informatics support. It will provide the infrastructure for the Research Concierge Services, the human and electronic approach to supporting clinical translational research. This platform will combine data-centered approaches to discovery by hosting and sharing datasets, applications, and other research objects with a human-centered approach to design and systems architecture. The Commons is designed to serve both as a technical framework and an approach to establishing processes and tools necessary to enable data sharing between partner locations. The Concierge service informs and connects researchers to training, support services and compliance resources to streamline the clinical translational research process. The mission of iTHRIV, through the Commons and the Concierge Services, is to remove barriers to discovery in Virginia and beyond. The iTHRIV Commons is conceptually similar to the NIH Data Commons, and the implementation of this framework across partner sites will remove barriers to data access and other research objects (algorithms, best practices, etc.), while enforcing compliance in the secure use of data. iTHRIV will marry the expertise of our world class data science teams in The Commons to our outstanding clinical translational researchers in order to uncover health care solutions.

弗吉尼亚州综合翻译健康研究所（ITHRIV）计划是 弗吉尼亚州的公共和私人机构带来了团队科学，创新， 以及培训下一代临床和翻译研究人员的承诺。我们的三个Ithriv 合作伙伴包括弗吉尼亚大学（弗吉尼亚州中部），弗吉尼亚理工大学卡里翁（西南弗吉尼亚州）和Inova 卫生系统（弗吉尼亚州北部）。我们的两个ITHRIV分支机构是开放科学的中心， 夏洛茨维尔的许可和风险投资集团。 ITHRIV的特殊优势在于整合数据 科学在临床转化研究的各个方面采取的方法，以加快发现和 改善我们社区的健康。 Ithriv有一个中央租户，可作为组织 原则：医疗保健解决方案隐藏在未充分利用的数据中。我们的总体目标是加深ITHRIV 支持临床转化研究的基础设施，以使各种农村和城市人口受益 ITHRIV成员临床医生服务。该CTSA组成部分的统一方法 应用是集成数据和数据分析以加速和简化科学工作流程 用于临床试验，创新的治疗进步以及创建更个性化的 医疗保健方法。数据科学是我们团队的特殊优势，将使我们能够 通过建立共享来改变我们的跨州信息学基础架构，这是一项可扩展的研究 由ITHRIV合作伙伴共享的托管平台将成为我们信息学支持的基础。它 将为研究礼宾服务，人类和电子方法提供基础设施 支持临床翻译研究。该平台将结合以数据为中心的方法 通过以人为本的托管和共享数据集，应用程序和其他研究对象来发现 设计和系统体系结构的方法。下议院旨在用作 技术框架以及建立所需的流程和工具的方法，以启用数据 在合作伙伴位置之间共享。礼宾服务将研究人员与培训联系起来， 支持服务和合规资源，以简化临床翻译研究过程。这 Ithriv的使命，通过Commons和Concierge服务，是消除发现的障碍 在弗吉尼亚及以后。 Ithriv Commons在概念上与NIH数据共享和 跨合作伙伴站点实施此框架将消除数据访问和其他数据的障碍 研究对象（算法，最佳实践等），同时在安全使用数据方面合规。 Ithriv将在Commons中将我们世界一流数据科学团队的专业知识与我们 出色的临床翻译研究人员，以发现医疗保健解决方案。