Center for Environmental and Health Effects of PFAS

PFAS 环境与健康影响中心

• 批准号: 10337301
• 负责人: CAROLYN J MATTINGLY
• 金额: $ 143.9万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-28 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10337301
• 关键词: Address; Analytical Chemistry; Animal Model; Area; Biological; Biology; Cell model; Collaborations; Communities; Community Health; Computational Technique; Cosmetics; Data Analyses; Data Science; Detection; Ensure; Environment; Environmental Engineering technology; Environmental Epidemiology; Environmental Exposure; Environmental Health; Environmental Pollution; Environmental Science; Epidemiology; Evaluation; Exposure to; Fostering; Fright; Goals; Government; Health; Human; Immune system; Immunology; Industrial Product; Infrastructure; Institutes; Knowledge; Leadership; Liver; Malignant Neoplasms; Manufacturer Name; Mus; North Carolina; Organism; Pathway interactions; Poison; Poly-fluoroalkyl substances; Population; Prevention; Prevention strategy; Public Health; Research; Research Project Grants; Research Support; Research Training; Resistance; Resources; Risk; Scientist; Stains; Structure; Superfund; System; Technology; Thyroid Function Tests; Thyroid Gland; Toxic effect; Toxicology; Training; Translational Research; Trust; United States Environmental Protection Agency; Universities; Water; Zebrafish; advanced analytics; base; bioaccumulation; chemical property; combinatorial; community engagement; community involvement; community partnership; consumer product; data management; data science management; data sharing; disease registry; exposed human population; health literacy; immune function; improved; innovation; instrumentation; next generation; programs; remediation; training opportunity

ABSTRACT Overall Per- and polyfluoroalkyl substances (PFAS) are emerging as a major public health problem in North Carolina (NC) and across the US. PFAS comprise a class of almost 5,000 known compounds. Their unique chemical properties have been harnessed to make consumer and industrial products more water, stain, and grease resistant; they are found in products as diverse as cosmetics and firefighting foams. Despite increasing evidence that they are found ubiquitously in the environment, there is a paucity of knowledge about their toxicity. For the few well-studied PFAS, associated health effects include cancer and toxicity to the liver, thyroid, and immune system; but human exposure levels, mechanisms of action, bioaccumulation, or effective remediation approaches remain unclear for the majority of PFAS. As a result of recent widespread detection in the environment and increasing evidence of human exposure we propose to establish a Superfund Research Program (SRP) Center for Environmental and Human Health Effects of PFAS. Several of these compounds are included on the Substance Priority List of the Agency for Toxic Substances and Disease Registry and are considered contaminants of emerging concern by the US Environmental Protection Agency. The long-term objective of our Center is to advance understanding about PFAS 1) environmental and human exposure in impacted areas, 2) toxicity and underlying mechanisms of thyroid and immune function, 3) bioaccumulation potential, and 4) remediation. To meet our objective we will employ a highly transdisciplinary approach that will integrate leaders in diverse fields (epidemiology, environmental science and engineering, biology, toxicology, immunology, data science, and advanced analytics) across two major NC Universities (NC State and East Carolina Universities); multiple levels of biological organization (biomolecule, pathway, cell, model organisms (periphyton, mayflies, zebrafish, mouse), and human populations); state-of-the-art analytical technologies; cutting-edge data science and management approaches; a recognized track record in interdisciplinary, environmental health science training; and well-established partnerships with government and community stakeholders. We aim to be a trusted resource for SRP stakeholders and impacted communities and to catalyze discovery of information that leads to prevention of PFAS exposure and protection of human health.

抽象的 全面的 北卡罗来纳州的主要公共卫生问题是每个氟烷基物质（PFA） （NC）和整个美国。 PFA包括近5,000种已知化合物的类。他们独特的化学物质 已利用物业使消费者和工业产品更多的水，污渍和油脂 抵抗的;它们是在化妆品和消防泡沫等产品中发现的。尽管增加了 证据表明它们在环境中无处不在，关于他们的知识很少 毒性。对于少数研究的PFA，相关的健康效应包括癌症和对肝脏的毒性，甲状腺， 和免疫系统；但是人类暴露水平，作用机制，生物蓄积或有效 对于大多数PFA，补救方法仍不清楚。由于最近广泛检测 我们建议建立超级基金研究的环境和越来越多的人类暴露证据 PFA的环境和人类健康影响计划（SRP）。其中几个 化合物包括在有毒物质和疾病机构的物质优先级中 注册表，被认为是美国环境保护局新兴关注的污染物。 我们中心的长期目标是提高对PFA的了解1）环境和 受影响地区的人类暴露，2）甲状腺和免疫的毒性和潜在机制 功能，3）生物积累的潜力和4）补救。为了实现我们的目标，我们将采用高度 跨学科方法将整合不同领域的领导者（流行病学，环境科学 以及两个主要的工程，生物学，毒理学，免疫学，数据科学和高级分析） NC大学（NC州立大学和东卡罗来纳大学）；生物组织的多个级别 （生物分子，途径，细胞，模型生物（叶叶顿，五叶，斑马鱼，小鼠）和人类 人口）；最先进的分析技术；尖端数据科学与管理 方法；跨学科，环境健康科学培训的公认记录；和 与政府和社区利益相关者建立了良好的伙伴关系。我们的目标是成为一个值得信赖的 SRP利益相关者并影响社区的资源，并催化引导信息的发现 预防PFAS暴露和保护人类健康。