Center for Environmental and Health Effects of PFAS

PFAS 环境与健康影响中心

基本信息

批准号：
10221364
负责人：
CAROLYN J MATTINGLY
金额：
$ 54.21万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-28 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10221364
关键词：
Acids Age Alligators Animals Archives Back Biological Blood Blood capillaries Blood specimen Body Burden Chemicals Chromatography Clinical Cohort Studies Collection Communities Concentration measurement Cross-Sectional Studies Data Environmental Health Fingerprint Fingers Fluorine Fright Funding Goals Health Human Individual Ions Location Measurement Measures Methods North Carolina Outcome Parents Participant Plants Poly-fluoroalkyl substances Population Reference Standards Research Personnel Research Project Grants Rivers Sampling Science Serum Signal Recognition Particle Source Spottings Superfund Surface System Techniques Technology Thyroid Gland Thyroid Hormones Time Training Universities Venous Water Whole Blood Work analytical method drinking water experimental study exposed human population field study guided inquiry liquid chromatography mass spectrometry method development minimally invasive novel remediation sample collection water treatment

项目摘要

Abstract The NC State Center for Environmental and Health Effects of PFAS focuses on understanding the implications of PFAS exposure in humans and animals in the Cape Fear River Basin of North Carolina. The Cape Fear River in North Carolina is characterized by high levels of a variety of PFAS (per-and poly-fluoroalkyl substances) throughout the watershed. The specific chemicals vary by location with the lower Cape Fear characterized by the presence of novel fluoroethers from chemical manufacturing near Fayetteville, NC, while upstream, the levels of legacy PFAS such as PFOA and PFOS are elevated and frequently exceed the drinking water advisory levels for these chemicals. To better characterize the diversity of PFAS exposures among impacted communities along the Cape Fear River, we have developed this supplement proposal to: 1) further characterize human exposure in communities upriver from Fayetteville, 2) expand analytical capabilities to measure total organic fluorine in biological and environmental samples, and 3) demonstrate feasibility for novel blood collection methods that can be employed in the field for both human and animal blood PFAS analysis.

抽象的 NC国家环境和健康效应中心的重点是理解 PFAS在人类和动物的含义北卡罗来纳州。北卡罗来纳州的开普敦恐惧河的特征是高水平整个流域中的多种PFA（每种氟烷基物质）。具体化学物质因位置而异，较低的恐惧的恐惧为特征来自北卡罗来纳州费耶特维尔附近的化学制造的荧光体，上游的水平 PFOA和PFO等传统PFA升高，并且经常超过饮用水这些化学物质的咨询水平。更好地描述PFA暴露的多样性在恐惧河沿线受影响的社区中，我们开发了这种补充提案：1）进一步描述了Fayetteville社区上游的人类暴露，2）扩大分析能力，以测量生物学和环境中总有机氟样品和3）证明了可以是新型血液收集方法的可行性用于人类和动物血液PFAS分析中。