Scholars in Environmental Pediatrics, Reproductive Health, and Life Course Science

环境儿科、生殖健康和生命过程科学学者

• 批准号: 10330306
• 负责人: Rosalind J Wright
• 金额: $ 34.05万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-12-01 至 2026-10-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10330306
• 关键词: Address; Caring; Child; Child Health; Childhood; Chronic Disease; Clinical; Country; Development; Discipline; Disease; Ecosystem; Environment; Environmental Health; Environmental Science; Fellowship Program; Genetic; Health; Health Professional; Healthcare; Human; Individual; Infrastructure; Institutes; Investments; Lead; Learning; Life; Life Cycle Stages; Medical; Mentored Clinical Scientist Development Program; Methods; Molecular; NCI Scholars Program; Outcome; Pediatrics; Perinatal; Physicians; Physiological; Plant Roots; Precision Medicine Initiative; Reproductive Health; Research; Role; Running; Science; Scientist; System; Toxin; Training; Translating; Translations; Vision; Workforce Development; clinical center; disorder prevention; disorder risk; early childhood; fetal; medical specialties; microbial; next generation; novel strategies; precision medicine; programs; ranpirnase; reproductive; research and development; social; workforce needs

The need to develop children's environmental health (CEH) clinician-scientists focused on the translation of pediatric and reproductive environmental health is critical. In parallel to the rise of developmental origins of health and disease (DOHaD) principles, precision medicine (PM) has emerged as the new approach in healthcare. PM seeks to transform medical care and disease prevention by identifying factors that more reliably predict individual risk for disease but has focused almost solely on genetics, even though environment is clearly a very large piece of the puzzle. With DOHaD principles suggesting that early life environment is at the root of most chronic diseases, a life course perspective to PM and pediatrics is needed to understand how human health is shaped by fetal and early childhood environments. Adverse health outcomes result from a multitude of environmental, social and microbial toxin-induced shifts in molecular, cellular, and physiological states and their interacting systems. Elucidating and translating the role of environment in health and development requires specific expert training. Mount training Institute (PEHSU) ecosystem Sinai has long been at the forefront of CEH clinical through the longest running pediatric environmental health fellowship program in the country, an for Exposomic Research, a P30 Core Center, a Pediatric Environmental Health Specialty Unit and a state run CEH clinical center. We are uniquely poised to leverage this well-established to continue to build national capacity in translational CEH through this exciting K12 program.Our program strives to advance a systematic plan to integrate environmental health into reproductive and pediatric PM initiatives to better address the root causes of disease. Many things are needed to realize this vision, but one of the most pressing is building the pediatric/perinatal translational workforce needed to lead this paradigm shift. Translation to better health outcomes will require developing broadly trained child health practitioners able to engage in transdisciplinary (TD) teams that extend beyond discipline-specific concepts, approaches, and methods. We seek to establish the Mount Sinai program for Scholars in Environmental Pediatrics, Reproductive Health, and Life Course Science embedded in a mature TD team science learning culture grounded in the principle that the major proportion of the variability in health outcomes is environmentally driven. This program will be led by environmental health physician-scientists and leverages Mount Sinai's longstanding commitment to CEH, our Region 2 PEHSU, our NY state children's environmental health centers, our established pipeline programs and regional networks to identify potential scholars, our infrastructure in pediatric/perinatal environmental health research and workforce development, and our institutional investments in exposomics. Our K12 program will develop healthcare professionals poised to integrate environmental science with established PM and pediatric care efforts and develop the next generation of versatile children's environmental health leaders.

需要开发儿童环境健康（CEH）临床医生 - 科学家的需求 小儿和生殖环境健康至关重要。与发展起源的兴起 健康与疾病（DOHAD）原理，精密医学（PM）已成为新方法 卫生保健。 PM试图通过确定更多的因素来改变医疗和疾病的预防 可靠地预测个人疾病风险，但几乎只关注遗传学，即使环境 显然是一个很大的难题。 Dohad的原则表明早期生活环境处于 大多数慢性疾病的根源，需要对PM和儿科的人生视角来了解如何 人类健康是由胎儿和幼儿环境塑造的。不良健康结果是由 多种环境，社会和微生物毒素诱导的分子，细胞和生理学的转移 国家及其交互系统。阐明和翻译环境在健康中的作用 开发需要特定的专家培训。山 训练 研究所 （PEHSU） 生态系统 西奈长期以来一直处于CEH临床的最前沿 通过该国运行时间最长的儿科环境健康奖学金计划 用于外博研究，P30核心中心，小儿环境健康专业单元 以及一个州经营的CEH临床中心。我们有独特的准备好利用这一良好的 继续通过这个令人兴奋的K12计划在CEH转化的国家能力。 计划努力推进系统的计划，将环境健康纳入生殖和小儿 PM更好地解决疾病根本原因的倡议。需要很多事情来实现这一愿景，但是 最紧迫的之一是建立领导此范式所需的小儿/围产期转化劳动力 转移。转化为更好的健康成果将需要开发经过广泛训练的儿童健康从业者 能够参与跨学科（TD）团队，这些团队超越了特定学科的概念，方法， 和方法。我们寻求为环境儿科学者建立西奈山计划， 生殖健康和生命课程科学嵌入了成熟的TD团队科学学习文化中 基于以下原则，即健康结果的主要变异性是环境 驱动。该计划将由环境健康医师科学家和西奈山的利用 长期以来对我们纽约州儿童环境卫生中心的CEH，我们2 PEHSU CEH的承诺， 我们已建立的管道计划和区域网络，以识别潜在的学者，我们的基础设施 小儿/围产期环境健康研究与劳动力发展以及我们的机构 展览组学的投资。我们的K12计划将培养有能力整合的医疗保健专业人员 通过既定的PM和儿科护理工作的环境科学，并发展下一代 多才多艺的儿童环境健康领导者。