Phenotyping and Environmental Modifier Facility Core

表型分析和环境修饰设施核心

• 批准号: 10388188
• 负责人: Rosalind J Wright
• 金额: $ 20.25万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-18 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10388188
• 关键词: Address; Adolescence; Adult; Age; Archives; Area; Behavior; Bioinformatics; Biological Markers; Biometry; Cardiometabolic Disease; Cardiovascular system; Chemical Modifier; Chemicals; Child; Childhood; Clinical; Clinical Research; Clinical and Translational Science Awards; Collaborations; Communities; Consultations; Core Facility; Data; Data Analyses; Data Collection; Development; Disease; Educational workshop; Electronic Health Record; Endocrine; Endocrine System Diseases; Ensure; Environmental Epidemiology; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Risk Factor; Equilibrium; Equipment; Exposure to; Faculty; Funding; Growth; Health; Health Sciences; Health Status; Health system; Hydrocortisone; Hypersensitivity; Immunophenotyping; Integration Host Factors; Intervention; Kidney; Kidney Diseases; Laboratories; Libraries; Life Cycle Stages; Link; Longevity; Measurement; Measures; Mediating; Mediation; Methodology; Methods; Mission; Modeling; Multivariate Analysis; National Institute of Environmental Health Sciences; Nutrition Assessment; Nutritional; Nutritional status; Obesity; Online Systems; Outcome; Oxidative Stress; Pathway interactions; Patient Self-Report; Phenotype; Physiological; Plasma; Population; Precision Medicine Initiative; Pregnancy; Procedures; Protocols documentation; Psychological Stress; Psychometrics; Psychosocial Stress; Research; Research Support; Resources; Risk; Salivary; Science; Services; Site; Societies; Standardization; Stress; Surveys; Technical Expertise; Time; Toxic Environmental Substances; Toxicant exposure; Training; Translational Research; Work; adipokines; base; built environment; clinical phenotype; contextual factors; critical period; data sharing; early childhood; health assessment; health data; health disparity; hypothalamic-pituitary-adrenal axis; immunoregulation; infancy; instrument; interoperability; meetings; member; neurodevelopment; nutrition; obesity-associated asthma; performance based measurement; phenomics; phenotypic data; pre-clinical; ranpirnase; research study; respiratory; response; sample collection; social determinants; social health determinants; socioeconomics; tool; toxicant; web portal

Project Summary Our Phenotyping and Environmental Modifier Facility Core (PEMFC) organizes Mount Sinai's extensive existing environmental epidemiology, clinical, psychometric, analytic and technical expertise as a key Center resource. The PEMFC helped catalyze the remarkable growth in environmental health research over the first 3 years of our Center linking environmental exposure and their modifiers to measures of health and development. The PEMFC provides Center Members access to expertise and state-of-the-art equipment necessary for clinical phenotyping and quantification of health and developmental outcomes across the lifespan as well as the measurement of modifiers of chemical environmental toxins. The PEMFC provides clinical, technical and scientific input to enhance the selection of age-appropriate valid, reliable and time effective low burden instruments to measure health and disease across the lifespan with particular focus on critical periods (pregnancy, infancy, early childhood, adolescence) . This includes Center supported space and phenotyping equipment covering target priority areas identified to date (neurodevelopment/behavior, obesity, asthma, allergy, endocrine, renal and cardiovascular phenotypes). The Core also facilitates translational research aimed toward more fully elucidating the impacts of key interactions between chemical toxicants and environmental modifiers across development, specifically psychological stress and other social determinants as well as nutrition. Given that exposure to chemical and non-chemical toxicants as well as nutritional status often track together along socioeconomic gradients, a related focus will be the multi-faceted elucidation of mechanisms underlying the health disparities observed in our local communities and more globally. The scope of responsibility for the PEMFC includes: 1) maintaining and providing access to adult and pediatric health assessments that include self-reports, observational data, and performance based measures; 2) assisting Center Members with rigorous and appropriate protocols to use when applying such measures in research studies; 3) advising on data analysis that includes psychometric analyses including the use of multiple phenotypes in a phenomic or true multivariate analysis; and 5) integrating environmental health with precision medicine initiatives at Mount Sinai. The PEMFC curates measures identified by our expert faculty together with the information needed to implement the measures including a summary of the psychometrics and detailed protocol(s) for data collection, scoring procedures, and incorporation into analyses. PEMFC faculty have particular expertise to guide selection of measures that can be characterized through a common standardized metric in order to facilitate data sharing, interoperability and harmonization to catalyze opportunities for Center Members to participate in collaborative multi-site studies. PEMFC faculty will also work with our clinical colleagues to integrate environmental health data with electronic health record data to catalyze environmental health translational research across the Mount Sinai Health System.

项目摘要 我们的表型和环境修饰设施核心（PEMFC）组织西奈山的广泛 现有的环境流行病学，临床，心理测量，分析和技术专长作为关键中心 资源。 PEMFC帮助催化了前3个中环境健康研究的显着增长 我们的中心多年将环境暴露及其修饰符与健康措施联系起来 发展。 PEMFC为中心成员访问专业知识和最先进的设备 对于临床表型和对健康和发展结果的量化所必需的 寿命以及化学环境毒素的修饰剂的测量。 PEMFC提供 临床，技术和科学意见，以增强适合年龄的有效，可靠和时间的选择 有效的低负担工具来衡量 整个生命周期的健康和疾病，特别关注 关键时期（怀孕，婴儿期，幼儿期，青春期） 。这包括中心支持的空间和 涵盖迄今确定的目标优先区域的表型设备（神经发育/行为，肥胖， 哮喘，过敏，内分泌，肾脏和心血管表型）。 核心还促进了翻译 旨在更充分阐明化学有毒物质与关键相互作用的影响的研究 跨发展的环境修饰符，特别是心理压力和其他社会决定因素 以及营养。鉴于暴露于化学和非化学毒物以及营养状况 通常沿着社会经济梯度一起跟踪，相关的重点将是多方面的阐明 在我们当地社区以及全球更大程度上观察到的健康差异的基础机制。这 PEMFC的责任范围包括：1）维护并提供对成人和儿科的机会 包括自我报告，观察数据和基于绩效的措施在内的健康评估； 2） 协助中心成员在应用此类措施时使用严格且适当的协议 研究； 3）关于数据分析的建议，包括心理测量分析，包括使用 现象或真实多元分析中的多种表型； 5）将环境健康与 西奈山的精密医学计划。 PEMFC策划了我们的专家教师确定的措施 以及实施措施所需的信息，包括精神计量学的摘要 以及用于数据收集，评分程序和集成分析的详细协议。 PEMFC 教师具有特殊的专业知识，可以指导选择的措施 可以通过一个共同的特征 标准化度量 为了促进 数据共享，互操作性和协调以催化 中心成员参加协作多站点研究的机会。 PEMFC教师也将工作 与我们的临床同事一起将环境健康数据与电子健康记录数据整合到催化 西奈山卫生系统的环境健康翻译研究。