Magnetically activated structures for minimally invasive endovascular therapy

用于微创血管内治疗的磁激活结构

• 批准号: 10302465
• 负责人: Shikui Chen
• 金额: $ 62.73万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10302465
• 关键词: Abdominal Aortic Aneurysm; Acoustics; Algorithms; Anatomy; Aneurysm; Angioplasty; Aortic Aneurysm; Aortic Diseases; Arteries; Atherosclerosis; Attention; Automobile Driving; Biological; Blood Vessels; Blood flow; Brain Aneurysms; Cerebral Aneurysm; Characteristics; Clinical; Complex; Coronary; Device Designs; Devices; Disease; Elastomers; Electronics; Endothelium; Engineering; Equipment Malfunction; Failure; Fatality rate; Feasibility Studies; Fracture; Future; Geometry; Goals; Heart Valves; In Situ; In Vitro; Ink; Life Expectancy; Limb structure; Liquid substance; Logic; Magnetism; Medical Device; Methods; Microscopic; Modality; Molecular Conformation; Motion; Movement; Neck; Operative Surgical Procedures; Optics; Patients; Peripheral; Pharmaceutical Preparations; Positioning Attribute; Prosthesis; Retreatment; Robotics; Rupture; Scanning; Shapes; Silicone Elastomers; Silicones; Site; Specific qualifier value; Stents; Stimulus; Structure; System; Testing; Therapeutic Embolization; Torque; Treatment outcome; Vascular Diseases; Vascular remodeling; Work; Writing; X-Ray Computed Tomography; abdominal aorta; active control; aortic valve; base; care outcomes; design; electric field; ferrite; flexibility; follow-up; heart valve replacement; hemodynamics; implantable device; implantation; improved; magnetic dipole; magnetic field; manufacturing process; migration; minimally invasive; next generation; novel; optimal treatments; particle; repaired; response; scaffold; seal; simulation; treatment optimization

PROJECT SUMMARY Magnetically activated structures (MAS) are flexible “smart” structural systems incorporating distributed actuators or control logics that can undergo desired deformations in a controlled manner. By incorporating magnetic dipole particles in pre-specified orientations within the structure, MAS can be programmed to generate adaptive and flexible movements in response to an external environmental stimulus through shape morphing, ranging from simple bending and folding, to some complex transformations. Our long- term goal is to leverage this versatility of MAS to optimize the treatment of vascular disease by developing actively controllable structures as opposed to the current treatment paradigm that involves static or passive devices. The focus of this project will be abdominal aortic aneurysms (AAA). AAA are abnormal dilations of the abdominal aorta that can rupture with a 75-80% fatality rate. In most patients with suitable anatomy and reasonable life expectancy, the preferred treatment modality for AAA is endovascular aneurysm repair (EVAR). EVAR involves percutaneous transfemoral access to the aneurysm site and endovascular deployment of stent grafts in the aortoiliac arteries in order to cover the entire aneurysm thereby effectively sealing the sac. The primary drawback of EVAR is the occurrence of endoleak (blood flows into the aneurysm around the stent graft), which must be treated urgently if it occurs due to stent- graft migration, kinking, or failure. Here, MAS-grafts will be designed using numerical topology optimization simulations such that the structures can be deformed in situ by a non-invasive magnetic field in order to conform to the vascular wall thereby mitigating leaks or migrations. Magnetic actuation can also be used to facilitate treatment of branches for complex cases. Any MAS-graft displacement observed during the follow-up period can be corrected for by non-invasively re-positioning the devices. We will accomplish this goal by the design of magnetically activated structures derived from patient AAA geometries (Specific Aim 1), and by conducting a feasibility study to assess fabrication and deployment of MAS grafts as well as computational fluid dynamics simulations to compare MAS grafts with the current grafts used to treat patients (Specific Aim 2).

项目概要 磁激活结构（MAS）是灵活的“智能”结构系统，结合了分布式 通过合并，可以以受控方式经历所需变形的执行器或控制逻辑。 磁偶极子粒子在结构内预先指定的方向，MAS 可以编程为 通过产生适应性和灵活的运动来响应外部环境刺激 形状变形，从简单的弯曲和折叠，到一些复杂的变换。 长期目标是利用 MAS 的多功能性，通过开发来优化血管疾病的治疗 主动可控结构，而不是当前涉及静态或 该项目的重点是腹主动脉瘤 (AAA) 异常。 腹主动脉扩张，大多数患者有 75-80% 的死亡率。 由于解剖结构和合理的预期寿命，AAA 的首选治疗方式是血管内治疗 动脉瘤修复术 (EVAR) 涉及经皮经股动脉进入动脉瘤部位和 在主髂动脉中血管内部署覆膜支架以覆盖整个动脉瘤 EVAR 的主要问题是发生内漏（血液）。 流入覆膜支架周围的动脉瘤），如果是由于支架引起的，必须紧急治疗 移植物迁移、扭结或失效在这里，MAS 移植物将使用数值拓扑进行设计。 优化模拟，使结构可以通过非侵入性磁场原位变形 为了顺应血管壁，从而减少磁致动。 也可用于促进治疗观察到的任何 MAS 移植物移位的分支。 在随访期间，我们将通过非侵入性地重新定位设备来纠正。 通过设计源自 AAA 患者的磁激活结构来实现这一目标 几何形状（具体目标 1），并通过进行可行性研究来评估制造和部署 MAS 移植物以及计算流体动力学模拟，以将 MAS 移植物与当前的进行比较 用于治疗患者的移植物（具体目标 2）。