Discovery Science Collaborative for CKDu

CKDu 发现科学合作

基本信息

批准号：
10300877
负责人：
VIVEK BHALLA
金额：
$ 70.53万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-25 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10300877
关键词：
Acute Acute Renal Failure with Renal Papillary Necrosis Affect Africa Agricultural Workers Agrochemicals Bioinformatics Biological Assay Biological Markers Biopsy Cells Central America Central Asia Characteristics Chronic Chronic Kidney Failure Clinical Collaborations Communities Country Data Data Coordinating Center Databases Developing Countries Diabetes Mellitus Disease Disease Progression Electrolytes Environmental Risk Factor Epidemiology Etiology Evaluation Far East Foundations Functional disorder Funding Genetic Predisposition to Disease Genetic study Genomics Geography Glomerular Filtration Rate Goals Heat Stress Disorders Heterogeneity Hypertension India Individual Inflammatory Infiltrate Infrastructure Injury Injury to Kidney International Investigative Techniques Kidney Kidney Diseases Leadership Manuals Mass Spectrum Analysis Metabolic Pathway Methods Molecular National Institute of Diabetes and Digestive and Kidney Diseases Natural History Nephrology Participant Pathogenesis Pathology Patients Physiology Population Predisposition Proteins Proteomics Recording of previous events Regulation Renal function Reporting Research Resources Risk Factors Role Sampling Science Serum Site South America Sri Lanka Technology Time Toxic Environmental Substances Tubular formation United States National Institutes of Health Work agricultural community base biobank biomarker development case control clinical phenotype community based participatory research comorbidity data integration design digital pathology emerging pathogen experience experimental study flexibility kidney biopsy machine learning algorithm metabolomics molecular pathology noninvasive diagnosis novel imaging technology outcome prediction pathogen single cell sequencing tool transcriptomics urinary working group

项目摘要

PROJECT SUMMARY / ABSTRACT The overall goal of the Discovery Science Collaborative for CKDu Renal Science Core is to bring the best investigative methods and scientific technology to the problem of CKDu. We will work closely with Field Epidemiology Sites, the Scientific Data Coordinating Center, NIDDK Leadership, the External Oversight Committee, and HHEAR to design clinical phenotyping studies and perform discovery science experiments. We will then integrate this data to elucidate the etiology and progression factors of CKDu occurring in diverse agricultural communities. The Renal Science Core is a multi-institutional collaborative organized around six Core components: Genomics, Pathology, Transcriptomics, Biomarkers, Physiology, and Bioinformatics. The specific aims of the RSC are to: (1) characterize the clinical phenotypes and natural history of patients with CKDu and unaffected individuals in CKDu-endemic regions, comparing features across CKDu sites and determining the degree of similarities and differences across sites and regions; (2) introduce cutting-edge molecular technologies to compare the risk factors and pathophysiology of CKDu across and within study sites to understand both shared and unique aspects of the etiology of disease; (3) define the relationship between AKI and CKDu in endemic regions; and (4) build a flexible, adaptable infrastructure for both hypothesis- and non-hypothesis-based approaches to understanding etiology that will form the core of ongoing CKDu studies. The leadership team of the RSC has extensive experience working on CKDu, a history of collaboration on international working groups, and leadership roles on other major NIDDK consortia. This group brings together expertise in nephrology, genomics, nephropathology, machine learning algorithms for digital pathology, single- cell transcriptomics, biomarker development, proteomics, metabolomics, renal physiology, bioinformatics, and data integration. We have also enlisted several advisors with expertise in novel pathogen discovery, novel imaging technologies, and environmental sampling. These studies will result in a greater understanding of the underlying pathophysiology of CKDu.

项目摘要 /摘要 CKDU肾科学核心的发现科学合作的总体目标是带来最好的 CKDU问题的研究方法和科学技术。我们将与领域紧密合作流行病学网站，科学数据协调中心，NIDDK领导力，外部监督委员会，以及设计临床表型研究并进行发现科学实验的HHEAR。然后，我们将整合这些数据，以阐明发生在多种多样的CKDU的病因和进展因素农业社区。肾科学核心是一个多机构的合作，大约有六个核心组成部分：基因组学，病理学，转录组学，生物标志物，生理学和生物信息学。这 RSC的具体目的是：（1）表征患者的临床表型和自然病史 CKDU和不受影响的人在CKDU流行地区，比较了CKDU站点的特征和确定站点和地区之间的相似性和差异的程度；（2）引入尖端分子技术比较研究地点和内部CKDU的危险因素和病理生理了解疾病病因的共同和独特方面；（3）定义 Aki和Ckdu在地方性地区；（4）为假设和基于非障碍的理解病因的方法将构成正在进行的CKDU研究的核心。 RSC领导团队在CKDU方面拥有丰富的经验，这是合作的历史国际工作组以及其他主要NIDDK财团的领导角色。这个小组聚集在一起肾脏病，基因组学，肾病学，机器学习算法的专业知识细胞转录组学，生物标志物发育，蛋白质组学，代谢组学，肾脏生理学，生物信息学和数据集成。我们还吸引了几位具有新颖的病原体发现专业知识的顾问，成像技术和环境抽样。这些研究将使人们对 CKDU的基础病理生理学。