Glomerular and Tubular Function in the Recovering Kidney

肾脏恢复中的肾小球和肾小管功能

• 批准号: 10587898
• 负责人: SCOTT Culver THOMSON
• 金额: $ 43.76万
• 依托单位: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2027-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10587898
• 关键词: Ablation; Acute; Acute Renal Failure with Renal Papillary Necrosis; Affect; Amino Acids; Angiotensins; Animals; Area; Behavior; Blood Pressure; Chronic Kidney Failure; Clinical; Clinical Trials; Compensation; Coupling; Creatinine clearance measurement; Data; Diagnosis; Diet; Disease; Electrolytes; Equilibrium; Event; Evolution; Excretory function; Feedback; Future; Glomerular Capillary; Glucose Transporter; Heterogeneity; Homeostasis; Hospitals; Human; Hypersensitivity; Hypoxia; Impairment; Incidence; Individual; Infarction; Infusion procedures; Injury; Injury to Kidney; Intervention; Ischemia; Kidney; Knowledge; Left; Liquid substance; Mathematics; Measures; Medical; Meta-Analysis; Metabolic stress; Metabolism; Methods; Micropuncture; Microscopic; Modeling; Nephrons; Outcome; Patients; Physiological; Physiology; Predisposition; Randomized; Rattus; Recovery; Regulation; Renal Blood Flow; Renal Mass; Renal function; Renin-Angiotensin System; Reperfusion Therapy; Research; Research Personnel; Saline; Sodium-Restricted Diet; Stress Tests; Techniques; Testing; Time; Tubular formation; Urine; absorption; base; design; dietary; experimental study; healing; hemodynamics; human model; human subject; improved; inhibitor; injured; preservation; pressure; prevent; response

Project Summary Abstract This research will provide information on the inner working of the kidney as it recovers from acute injury. Recovery of the kidney from acute injury is often incomplete and leaves behind a kidney that is prone to subsequent permanent decline due to physical and metabolic stresses of trying to compensate for incomplete healing. Ideally, targeted intervention would hasten recovery from acute kidney injury and diminish its long- term consequences. However, major knowledge gaps in the area of renal recovery currently preclude a rational approach to treatment. Knowledge gaps include the physical reason why the injured kidney appears to filter less fluid, the vulnerability of the injured kidney to be further injured by changes in blood pressure, or whether standard medical treatments or prescribed diets are helpful or harmful in patients recovering from kidney injury. Kidney features that are observed at the whole-kidney level emerge from events at the microscopic level and treatments have their direct effect at the microscopic level. However, there can be multiple combinations of microscopic events that could account for a given observation at the whole-kidney level. Therefore, microscopic behavior cannot be deduced from whole-kidney behavior and must be observed directly. This cannot be done in humans but can be done in rat models of human kidney injury using specialized techniques uniquely available to the investigators. Through these methods, this research will determine the effects of simple maneuvers on multiple internal variables thereby establishing boundary conditions for efficient design of future clinical trials in the field of kidney recovery.

项目摘要摘要 这项研究将提供有关肾脏从急性损伤中恢复的内部工作的信息。 从急性损伤中恢复肾脏通常是不完整的，并且在容易发生的肾脏后留下 随后由于身体和代谢压力而导致的永久性下降，试图补偿不完整 康复。理想情况下，有针对性的干预将加快急性肾脏损伤的恢复，并减少其长期 术语后果。但是，肾脏回收领域的主要知识差距目前排除了合理的理性 治疗方法。知识差距包括受伤肾脏似乎过滤少的物理原因 液体，受伤肾脏的脆弱性会因血压变化而进一步受伤，或者是否是 标准药物治疗或处方饮食对从肾脏损伤中康复的患者有用或有害。 从微观层面的事件和 治疗在微观水平上具有直接作用。但是，可以有多种组合 可以在整个Kidney级别上考虑给定观察的微观事件。因此，显微镜 行为不能从全凯尼行为中推断出来，必须直接观察到。这不能在 人类，但可以使用专门的技术在人体肾脏损伤的大鼠模型中进行 给调查人员。通过这些方法，这项研究将确定简单操纵对 多个内部变量，从而建立了边界条件以有效设计未来的临床试验 在肾脏恢复领域。