TRACER Developmental Research Program

TRACER发展研究计划

基本信息

批准号：
10290166
负责人：
VICTORIA L. SEEWALDT
金额：
$ 17.23万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-20 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10290166
关键词：
Academic Medical Centers Address African American Air Pollution Asians Basic Science Behavioral Behavioral Research California Cancer Center Catchment Area Center for Translational Science Activities Characteristics Cities City of Hope Comprehensive Cancer Center Clinical Treatment Clinical Trials Collaborations Communities Community based prevention Core Facility Country Data Development Diagnostic Ensure Epidemiology Ethnic Origin Evaluation Face Financial Support Fostering Funding Future Geography Goals Grant Hispanics Human Individual Institution Intervention Latinx Leadership Los Angeles Malignant neoplasm of lung Medical Monitor National Cancer Institute Outcomes Research Pilot Projects Population Population Heterogeneity Poverty Process Program Research Project Grants Race Reporting Research Research Personnel Research Project Grants Resources Rural Sampling Shapes Site Smoking South Carolina Translating Translational Research Universities Virginia Woman black men cancer health disparity epidemiology study health disparity innovation men non-smoking preventive intervention programs racial and ethnic rural area success urban area

项目摘要

DEVELOPMENTAL RESEARCH PROGRAM: PROJECT SUMMARY The Developmental Research Program (DRP) within this P20 Translational Research Center in Lung Cancer Disparities (TRACER) application aims to select and support highly promising and innovative pilot research projects to reduce health disparities in lung cancer. The TRACER MPI and DRP leadership (representing the 3 participating National Cancer Institute-designated cancer centers at Virginia Commonwealth University, Medical University of South Carolina, and City of Hope) have set clear priorities for the selection of pilot research projects. These priorities are (1) projects demonstrating exceptional translational science potential, (2) projects inclusive of vertical and horizontal collaborations between the 3 participating institutions, and (3) projects with maximum impact on the diverse communities serving—Virginia, South Carolina, and southern California. These pilot research projects may include basic research explorations using human samples, diagnostic or treatment clinical interventions in the form of clinical trials, or community-based prevention interventions. A major advantage of this 3-institution P20 TRACER collaborative is that it provides immediate access to distinct urban and rural regions with vastly different racial/ethnic compositions as well as cultural and environmental characteristics that likely contribute to the disparities reported in lung cancer (e.g., large African American/Black populations in Virginia and South Carolina and large Hispanic/LatinX and Asian populations in southern California, high rates of smoking in Virginia and South Carolina; high levels of air pollution in southern California). The DRP will provide direct and significant financial support for competitively selected pilot research projects and will provide these pilot project PIs or investigative teams with access to the expertise and resources of the TRACER-supported cores and an extraordinary list of other cutting-edge resources available within the 3 participating institutions. The leaders of the DRP will select and fund a minimum of 3 pilot research projects annually, and the projects’ progress will be carefully monitored by multi-levels of internal and external scientific and community advisors. The ultimate goal of the DRP is to establish a pipeline of research focused on the multi-dimensional causes of lung cancer disparities within the diverse populations served by the partnering institutions and to develop the preliminary data to support competitive research projects for a future, collaborative P50 SPORE application.

发展研究计划：项目摘要 P20 肺癌转化研究中心的发展研究计划 (DRP) Disparities (TRACER) 应用程序旨在选择和支持极具前景和创新的试点研究减少肺癌健康差异的项目 TRACER MPI 和 DRP 领导层（代表 3 个）参与国家癌症研究所指定的弗吉尼亚联邦大学、医学院的癌症中心南卡罗来纳大学和希望之城）为试点研究项目的选择制定了明确的优先事项。这些优先事项是 (1) 展示卓越转化科学潜力的项目，(2) 包容性项目 3个参与机构之间的纵向和横向合作，以及（3）最大程度的项目对服务的不同社区（弗吉尼亚州、南卡罗来纳州和南加州）的影响。研究项目可能包括使用人体样本的基础研究探索、诊断或治疗临床以临床试验或基于社区的预防干预形式进行干预的一个主要优点。这个 3 机构 P20 TRACER 合作的特点是，它提供了直接访问不同城市和农村的途径种族/族裔构成以及文化和环境特征截然不同的地区可能导致肺癌报告的差异（例如，大量非洲裔美国人/黑人人口弗吉尼亚州和南卡罗来纳州以及南加州的大量西班牙裔/拉丁裔和亚裔人口，比率很高弗吉尼亚州和南卡罗来纳州的吸烟率；南加州的严重空气污染）。为竞争性选择的试点研究项目提供直接和重要的财政支持，并将提供这些试点项目 PI 或调查团队能够获得 TRACER 支持的专业知识和资源核心以及 3 个参与机构内可用的其他尖端资源的非凡清单。 DRP 的领导者每年将选择并资助至少 3 个试点研究项目，并且这些项目的多层次的内部和外部科学和社区顾问将仔细监测进展情况。 DRP 的最终目标是建立一个研究渠道，重点关注疾病的多维原因。合作机构所服务的不同人群中肺癌的差异，并制定支持未来协作 P50 SPORE 应用的竞争性研究项目的初步数据。