Core 4: Shared Resource - Capacity Development

核心 4：共享资源 - 能力发展

• 批准号: 10762159
• 负责人: VICTORIA L. SEEWALDT
• 金额: $ 21.91万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-22 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10762159
• 关键词: Award; Basic Science; California; Cancer Center Planning Grant; City of Hope Comprehensive Cancer Center; Clinical Trials; Collaborations; Comprehensive Cancer Center; Development; Disparity; Engineering; Evaluation; Funding; Genomics; Goals; Grant; Institution; Instruction; Joints; Mentors; Mentorship; Monitor; Pharmaceutical Preparations; Pilot Projects; Qualifying; Research; Research Personnel; Resource Development; Resource Sharing; Resources; Schedule; Structure; Tissue Banks; Translational Research; United States National Institutes of Health; Universities; Writing; drug development; education research; experience; medical schools; meetings; success; translational impact

It is challenging to build successful research collaborations. Successful collaborations are even more challenging when working across institutions and with early-stage investigators (ESIs). To overcome these challenges, we developed the Capacity Building Core. The Core's goal is to provide resources and mentorship to build joint collaborations between City of Hope Comprehensive Cancer Center (CoHCCC) and University of California, Riverside (UCR) ESI. We aim to build collaborations that 1) increase UCR capacity for drug development capacity - at all stages of the drug-develop pipeline and 2) result in independent NIH-funding. The Capacity Core will match UCR ESIs with senior CoHCCC and UCR investigators. Senior CoHCCC investigators will be selected based on their prior proven ability to 1) successfully mentor ESIs and 2) help them attain independent NIH funding. U54 PI, Drs. Ernest Martinez (UCR) and Victoria Seewaldt (CoH) have extensive mentorship experience and will lead the Capacity Core. Under the Capacity Core, UCR-CoH Mini-Pilots will be 1) crafted by ESIs under senior mentorship, 2) competed, and 3) teams awarded $100,000 for one year. Our P20 planning grant shows us that success of a pilot project is increased when ESI have senior mentors from both CoH and UCR; therefore UCR ESI applying for Mini-Pilots are required to have a CoH and UCR mentor. In Years 1 and 2 a total of 3 Mini-Pilots will be funded/year. These 6 Mini-Pilots will be an important opportunity for us to build joint UCR ESI-CoH grants and capacity at UCR. In Years 3-5, $200,000 originally allocate to the Capacity Building Core, will be re-allocated to support two new Pilots – Pilots 3 and 4. In Years 3-5, we will offer 1 Mini- Pilot/year. CoH discretionary funds ($100,000/year) will allow us to either supplement Pilot Projects or increase the number of Mini-Pilots offered in Years 3-5.

建立成功的研究合作具有挑战性，成功的合作更具挑战性。 当跨机构与早期研究人员 (ESI) 合作时，我们会克服这些挑战。 制定了能力建设核心，该核心的目标是提供资源和指导来建立联合。 希望之城综合癌症中心 (CoHCCC) 与加州大学之间的合作， Riverside (UCR) ESI 我们的目标是建立以下合作：1) 提高 UCR 的药物开发能力。 能力 - 药物开发流程的所有阶段以及 2) 获得独立的 NIH 资助。 Core 将把 UCR ESI 与高级 CoHCCC 进行匹配，并且 UCR 高级 CoHCCC 调查员将是。 选择的依据是他们之前已证明有能力 1) 成功指导 ESI 和 2) 帮助他们实现独立 NIH 资助的 U54 PI、Ernest Martinez 博士 (UCR) 和 Victoria Seewaldt (CoH) 拥有广泛的指导。 经验并将领导容量核心 在容量核心下，UCR-CoH Mini-Pilots 将由 1) 制作。 ESI 在高级指导下，2) 参加比赛，3) 团队获得了为期一年的 100,000 美元奖励。 赠款向我们表明，当 ESI 拥有来自 CoH 和 CoH 的高级导师时，试点项目的成功率会提高。 UCR；因此，申请迷你试点的 UCR ESI 需要在第一年和第一年有一名 CoH 和 UCR 导师。 2 每年将资助 3 个迷你试点项目 这 6 个迷你试点项目将是我们建设的重要机会。 UCR ESI-CoH 联合拨款和 UCR 能力 在第 3-5 年，最初分配给能力 200,000 美元。 构建核心，将被重新分配以支持两个新的试点项目 - 试点项目 3 和 4。在第 3-5 年，我们将提供 1 个迷你项目 试点/年。CoH 可自由支配资金（100,000 美元/年）将使我们能够补充试点项目或增加试点项目。 第 3-5 年提供的迷你试点项目的数量。