Uncovering and Surveilling Financial Deception Risk in Aging - Alzheimer's Disease Supplement

发现和监测老龄化过程中的财务欺诈风险 - 阿尔茨海默氏病补充剂

基本信息

批准号：
10286756
负责人：
Natalie C Ebner
金额：
$ 36.45万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10286756
关键词：
Address Adult Age Aging Alleles Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk American Behavior Brain Clinical Cognitive Communities Data Data Collection Deception Decision Making Dementia Discrimination Disease Elderly Electronic Mail Epidemic Family history of Fraud Future Genetic Markers Genomics Genotype Goals Health Status Hippocampus (Brain)Impaired cognition Impairment Individual Infrastructure Insula of Reil Internet Intervention Investigation Knowledge Laboratories Life Link Literature Longevity Measures Modeling Neurobiology Neuropsychology Neurosciences Performance Phenotype Population Predisposition Public Health Publishing Quality of life Research Risk Role Sampling Structure Testing Work aged apolipoprotein E-4 base brain volume cognitive function cognitive testing cohort cost decision-making capacity digital experimental study fall risk financial decision making financial exploitation gray matter healthy aging high risk middle age neglect novel parent grant pathological aging phenotypic data phishing

项目摘要

Abstract of the proposed supplement highlighting the relevance to AD/ADRD Financial loss due to reduced decision-making capacity and increased risk of deception constitutes a burgeoning public health crisis. A digitally connected world has shifted financial fraud into the online realm. Healthy older adults and those with dementia (e.g., Alzheimer’s disease) may be at particular risk for financial exploitation in an online context, as they must navigate the complexities and ambiguity of internet decision making while also dealing with cognitive, socioemotional, and neurobiological changes associated with age and the disease. These individuals at heightened exploitation risk, however, are neglected in research on cyberattacks. One strategy for closing this knowledge gap, in alignment with the parent grant’s goal of determining financial deception risk profiling, is to uncover the impact of higher risk for accelerated cognitive decline and Alzheimer’s disease on online decision making. From this perspective, under the umbrella of the parent grant, the goal of the supplement is to determine in the parent grant cohort apolipoprotein E4 (APOE4) allele status, which increases risk for Alzheimer’s disease. The supplement will further extend risk surveillance and profiling into the MindCrowd project, which comprises a larger adult lifespan sample previously genotyped for APOE4 status, cognitively phenotyped, and for whom first-degree family history of Alzheimer’s disease is known. The supplement will (i) determine whether APOE4 carriers are at increased susceptibility to financial exploitation in aging (AIM 1); (ii) investigate APOE4 impact on the link between cognitive/socioemotional functions and financial exploitation risk in aging (AIM 2); and (iii) determine the role of APOE4 status on associations between brain structure, brain function, and financial exploitation risk in aging (AIM 3). These novel AD/ADRD supplement aims are embedded in our Cognitive/Socioemotional Neuroscience Model of Financial Decision-Making and Deception Risk in Aging and build on preliminary data from the parent grant supporting high susceptibility to online deception among older adults in our ecologically valid, behavior-based field experiment (PHishing Internet Task; PHIT) and particular risk susceptibility among APOE4 allele carriers in our newly developed Phishing Email Suspicion Test (PEST); especially among APOE4 carriers with low cognitive function. This supplement will leverage the established infrastructure of the parent grant to genotype the parent grant cohort of N=280 young, middle-aged, and older adults on APOE4 status (Study 1); and uniquely broaden data collection by administering our two new online fraud susceptibility paradigms (PHIT, PEST) as well as a short socioemotional/financial decision making battery in the MindCrowd cohort (N=1,000; 20-95 years; Study 2). Results from this supplement will allow extension of our integrated, conceptually driven approach to financial exploitation risk profiling into pathological aging, with potential to inform real-life decision- supportive interventions to reduce exploitation risks in healthy aging and Alzheimer’s disease.

支撑性供应的摘要突出了与AD/ADRD的相关性由于决策能力降低和决策征兵的风险增加而造成的财务损失A。挖掘公共卫生危机。健康的老年人和患有痴呆症患者（例如，阿尔茨海默氏病）可能有特殊风险在在线环境中的剥削，因为他们唤起了互联网决定的复杂性和歧义同时还要处理认知，社会情感和神经果仁洛洛洛洛洛洛洛洛洛洛洛洛洛洛洛洛洛洛洛洛洛洛洛洛洛洛洛的变化但是，这些处于高度剥削风险的疾病网络攻击。确定财务决策风险分析是对加速认知的高风险的影响在线决策的衰落和阿尔茨海默氏病。父母的赠款，建议的目的是确定父授予群体Apolipopopopopotin E4（APOE4）等位基因状况，增加了阿尔茨海默氏病的风险。并介绍了Mind Crowd项目，该项目构成了先前基因型的较大成人寿命样本 For Apoe4 Status, Cognitively Phenotyped, and for Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom Whom谁已知。衰老中的剥削（目标1）；（ii）APOE4对认知/社会情感之间的联系衰老的功能和财务剥削风险（AIM 2）和（iii）大脑结构，大脑功能和衰老的财务剥削风险之间的关联（AIM 3）新颖的AD/AD/AD/AIM嵌入了我们的认知/社会情感神经科学模型衰老中的财务决策和决策风险，并基于父母赠款的预临时数据在我们的生态有效的，基于行为现场实验（网络钓鱼互联网任务在我们新开发的网络钓鱼电子邮件怀疑测试（害虫）中；认知功能。 n = 280名年轻，中年和老年人的父母授予的同伴（研究1）；通过管理我们的两个新的在线欺诈发作范例（Phit，Phit，害虫）以及Mindcrowd队列中的短期社会情感/财务决策电池（n = 1,000； 20-95年；研究结果财务剥削的方法将风险分配到病理衰老中，并有潜力信息现实生活中的决策 - 支持性干预措施，以减少健康衰老和阿尔茨海默氏病的剥削风险。