Uncovering and Surveilling Financial Deception Risk in Aging - Alzheimer's Disease Supplement

发现和监测老龄化过程中的财务欺诈风险 - 阿尔茨海默氏病补充剂

• 批准号: 10286756
• 负责人: Natalie C Ebner
• 金额: $ 36.45万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10286756
• 关键词: Address; Adult; Age; Aging; Alleles; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Behavior; Brain; Clinical; Cognitive; Communities; Data; Data Collection; Deception; Decision Making; Dementia; Discrimination; Disease; Elderly; Electronic Mail; Epidemic; Family history of; Fraud; Future; Genetic Markers; Genomics; Genotype; Goals; Health Status; Hippocampus (Brain); Impaired cognition; Impairment; Individual; Infrastructure; Insula of Reil; Internet; Intervention; Investigation; Knowledge; Laboratories; Life; Link; Literature; Longevity; Measures; Modeling; Neurobiology; Neuropsychology; Neurosciences; Performance; Phenotype; Population; Predisposition; Public Health; Publishing; Quality of life; Research; Risk; Role; Sampling; Structure; Testing; Work; aged; apolipoprotein E-4; base; brain volume; cognitive function; cognitive testing; cohort; cost; decision-making capacity; digital; experimental study; fall risk; financial decision making; financial exploitation; gray matter; healthy aging; high risk; middle age; neglect; novel; parent grant; pathological aging; phenotypic data; phishing

Abstract of the proposed supplement highlighting the relevance to AD/ADRD Financial loss due to reduced decision-making capacity and increased risk of deception constitutes a burgeoning public health crisis. A digitally connected world has shifted financial fraud into the online realm. Healthy older adults and those with dementia (e.g., Alzheimer’s disease) may be at particular risk for financial exploitation in an online context, as they must navigate the complexities and ambiguity of internet decision making while also dealing with cognitive, socioemotional, and neurobiological changes associated with age and the disease. These individuals at heightened exploitation risk, however, are neglected in research on cyberattacks. One strategy for closing this knowledge gap, in alignment with the parent grant’s goal of determining financial deception risk profiling, is to uncover the impact of higher risk for accelerated cognitive decline and Alzheimer’s disease on online decision making. From this perspective, under the umbrella of the parent grant, the goal of the supplement is to determine in the parent grant cohort apolipoprotein E4 (APOE4) allele status, which increases risk for Alzheimer’s disease. The supplement will further extend risk surveillance and profiling into the MindCrowd project, which comprises a larger adult lifespan sample previously genotyped for APOE4 status, cognitively phenotyped, and for whom first-degree family history of Alzheimer’s disease is known. The supplement will (i) determine whether APOE4 carriers are at increased susceptibility to financial exploitation in aging (AIM 1); (ii) investigate APOE4 impact on the link between cognitive/socioemotional functions and financial exploitation risk in aging (AIM 2); and (iii) determine the role of APOE4 status on associations between brain structure, brain function, and financial exploitation risk in aging (AIM 3). These novel AD/ADRD supplement aims are embedded in our Cognitive/Socioemotional Neuroscience Model of Financial Decision-Making and Deception Risk in Aging and build on preliminary data from the parent grant supporting high susceptibility to online deception among older adults in our ecologically valid, behavior-based field experiment (PHishing Internet Task; PHIT) and particular risk susceptibility among APOE4 allele carriers in our newly developed Phishing Email Suspicion Test (PEST); especially among APOE4 carriers with low cognitive function. This supplement will leverage the established infrastructure of the parent grant to genotype the parent grant cohort of N=280 young, middle-aged, and older adults on APOE4 status (Study 1); and uniquely broaden data collection by administering our two new online fraud susceptibility paradigms (PHIT, PEST) as well as a short socioemotional/financial decision making battery in the MindCrowd cohort (N=1,000; 20-95 years; Study 2). Results from this supplement will allow extension of our integrated, conceptually driven approach to financial exploitation risk profiling into pathological aging, with potential to inform real-life decision- supportive interventions to reduce exploitation risks in healthy aging and Alzheimer’s disease.

拟议补充的摘要突出了与AD/ADRD的相关性 由于决策能力降低和欺骗风险的增加而构成的财务损失构成 蓬勃发展的公共卫生危机。以数字联系的世界将金融摩擦转移到了在线领域。 健康的老年人和患有痴呆症患者（例如，阿尔茨海默氏病）可能有特殊风险 在线环境中的剥削，因为他们必须浏览互联网决策的复杂性和歧义 同时还要处理与年龄相关的认知，社会情感和神经生物学变化 和疾病。然而，这些处于剥削风险加剧的人在研究中被忽略了 网络攻击。缩小这一知识差距的一种策略，与父母赠款的目标保持一致 确定财务欺骗风险分析，是要揭示加速认知的较高风险的影响 衰落和阿尔茨海默氏病在在线决策中。从这个角度来看， 父母赠款，补充的目的是在父授予授予群体apolipopopotin E4（APOE4）中确定 等位基因状态，增加了阿尔茨海默氏病的风险。补充剂将进一步扩展风险监视 并分析了MindCrowd项目，该项目包括先前基因型的较大成人寿命样本 对于APOE4状态，认知表型，而阿尔茨海默氏病的一级家族史是 已知。补充剂将（i）确定APOE4承运人是否对财务敏感性增加 衰老中的剥削（目标1）； （ii）研究APOE4对认知/社会情感之间的联系的影响 衰老的功能和财务剥削风险（AIM 2）； （iii）确定apoe4状态在 大脑结构，大脑功能和衰老中的财务剥削风险之间的关联（AIM 3）。这些 新颖的AD/ADRD补充剂目标嵌入了我们的认知/社会情感神经科学模型中 衰老的财务决策和欺骗风险，并基于父母赠款的初步数据 在我们的生态有效，基于行为 现场实验（网络钓鱼互联网任务； PHIT）以及APOE4等位基因运营商中的特殊风险敏感性 在我们新开发的网络钓鱼电子邮件怀疑测试（PEST）中；尤其是在低apoe4载体中 认知功能。这种补充将利用父母授予基因型的既定基础设施 n = 280岁的年轻，中年和老年人的父母赠款队列的APOE4状态（研究1）；和 通过管理我们两个新的在线欺诈易感性范例（Phit，Phit， 害虫）以及Mindcrowd队列中的短期社会情感/财务决策电池（n = 1,000； 20 - 95年；研究2）。该补充的结果将允许扩展我们的集成，概念驱动的 财务剥削的方法将风险分配到病理衰老中，有可能告知现实生活的决策 - 支持干预措施，以减少健康衰老和阿尔茨海默氏病的剥削风险。