Core 5: Biostatistics and Bioinformatics

核心 5：生物统计学和生物信息学

基本信息

批准号：
10226190
负责人：
Giovanni Luigi PARMIGIANI
金额：
$ 16.6万
依托单位：
DANA-FARBER CANCER INST
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-12-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10226190
关键词：
Address Basic Science Behavioral Mechanisms Bioinformatics Biology Biometry Biostatistics Core Cells Clinical Clinical Data Clinical Research Clinical Trials Clonal Evolution Collaborations DNA Sequence Alteration Data Data Analyses Dependence Development Disease Enhancers Evaluation Funding Genes Genomic Instability Genomics Goals Grant Individual International Interruption Lead Lesion Maintenance Maintenance Therapy Mediator of activation protein Methods Molecular Multiple Myeloma Outcome Pathogenesis Patient-Focused Outcomes Patients Procedures Process Prognosis Quality Control Randomized Research Research Personnel Resistance Resources Role SNP genotyping Sampling Schedule Specimen Therapeutic Translating Work base cancer genomics cell growth clinically relevant data exchange data warehouse design epigenomics high throughput analysis improved member miRNA expression profiling new therapeutic target next generation next generation sequencing novel therapeutic intervention novel therapeutics outcome prediction phase 3 study pre-clinical programs response second transplant success survival outcome targeted treatment transcriptomics

项目摘要

Project Summary (Core 5) Studies from the previous grant period confirmed that achieving MRD negative (sensitivity of 1 cell in 10-6) status provides significantly superior progression free and overall survival outcome. In this proposal, we will address the question of how MRD status will inform the therapeutic approach in a randomized phase III study comparing two maintenance schedules for MRD negative patients. To support this effort, the Bioinformatics and Biostatistics Core E will provide 1) support and direction on the formatting, quality control and annotation procedures of clinical and research data as well as the process of transferring the research data a data warehouse for integrative analysis, 2) bioinformatics support for primary and integrative analysis of the high- throughput data and 3) biostatistics support in terms of design and analysis for all projects. Core members will work closely with project members as well as Cores 1 and 2 with regard to quality control, specimen tracking and data transfer procedures as well as Cores 3 and 4 which will perform microarray based gene and miRNA expression profiling, and SNP genotyping and next generation sequencing for identifying genomic and transcriptomic changes. Bioinformatics and biostatistics support and analysis is not only required for individual projects, but it is crucial for the integrative analysis from data across the projects and thus overall success of the program.

项目摘要（核心 5）上一资助期的研究证实，实现 MRD 阴性（10-6 中 1 个细胞的敏感性）状态提供显着优越的无进展生存和总生存结果。在本提案中，我们将解决 MRD 状态如何影响随机 III 期研究中的治疗方法的问题比较 MRD 阴性患者的两种维持计划。为了支持这项工作，生物信息学生物统计学核心 E 将提供 1) 有关格式、质量控制和注释的支持和指导临床和研究数据的程序以及研究数据和数据的传输过程综合分析仓库，2）生物信息学支持高通量的初级和综合分析吞吐量数据和 3) 生物统计学在所有项目的设计和分析方面的支持。核心成员将与项目成员以及核心 1 和 2 在质量控制、样本跟踪方面密切合作和数据传输程序以及核心 3 和 4，它们将执行基于基因和 miRNA 的微阵列表达谱分析、SNP 基因分型和下一代测序，用于识别基因组和转录组变化。生物信息学和生物统计学的支持和分析不仅是个人所需要的项目，但对于跨项目数据的综合分析以及因此的整体成功至关重要程序。