Core 5: Biostatistics and Bioinformatics

核心 5：生物统计学和生物信息学

基本信息

批准号：
10226190
负责人：
Giovanni Luigi PARMIGIANI
金额：
$ 16.6万
依托单位：
DANA-FARBER CANCER INST
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-12-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10226190
关键词：
Address Basic Science Behavioral Mechanisms Bioinformatics Biology Biometry Biostatistics Core Cells Clinical Clinical Data Clinical Research Clinical Trials Clonal Evolution Collaborations DNA Sequence Alteration Data Data Analyses Dependence Development Disease Enhancers Evaluation Funding Genes Genomic Instability Genomics Goals Grant Individual International Interruption Lead Lesion Maintenance Maintenance Therapy Mediator of activation protein Methods Molecular Multiple Myeloma Outcome Pathogenesis Patient-Focused Outcomes Patients Procedures Process Prognosis Quality Control Randomized Research Research Personnel Resistance Resources Role SNP genotyping Sampling Schedule Specimen Therapeutic Translating Work base cancer genomics cell growth clinically relevant data exchange data warehouse design epigenomics high throughput analysis improved member miRNA expression profiling new therapeutic target next generation next generation sequencing novel therapeutic intervention novel therapeutics outcome prediction phase 3 study pre-clinical programs response second transplant success survival outcome targeted treatment transcriptomics

项目摘要

Project Summary (Core 5) Studies from the previous grant period confirmed that achieving MRD negative (sensitivity of 1 cell in 10-6) status provides significantly superior progression free and overall survival outcome. In this proposal, we will address the question of how MRD status will inform the therapeutic approach in a randomized phase III study comparing two maintenance schedules for MRD negative patients. To support this effort, the Bioinformatics and Biostatistics Core E will provide 1) support and direction on the formatting, quality control and annotation procedures of clinical and research data as well as the process of transferring the research data a data warehouse for integrative analysis, 2) bioinformatics support for primary and integrative analysis of the high- throughput data and 3) biostatistics support in terms of design and analysis for all projects. Core members will work closely with project members as well as Cores 1 and 2 with regard to quality control, specimen tracking and data transfer procedures as well as Cores 3 and 4 which will perform microarray based gene and miRNA expression profiling, and SNP genotyping and next generation sequencing for identifying genomic and transcriptomic changes. Bioinformatics and biostatistics support and analysis is not only required for individual projects, but it is crucial for the integrative analysis from data across the projects and thus overall success of the program.

项目摘要（核心5）从上一个赠款期开始的研究证实，达到MRD阴性（10-6中1个细胞的灵敏度）地位提供了明显的无进展和总体生存结果。在此提案中，我们将解决MRD状态如何在随机阶段研究中为治疗方法提供信息的问题比较MRD阴性患者的两个维护时间表。为了支持这一努力，生物信息学生物统计学核心E将提供1）对格式，质量控制和注释的支持和指导临床和研究数据的程序以及传输研究数据的过程用于综合分析的仓库，2）生物信息学支持高级和综合分析吞吐量数据和3）在所有项目的设计和分析方面的生物统计学支持。核心成员会与项目成员以及核心1和2有关质量控制，标本跟踪紧密合作以及将执行基于微阵列的基因和miRNA的数据传输程序以及核3和4 表达分析，SNP基因分型和下一代测序，用于鉴定基因组和转录组变化。生物信息学和生物统计学支持和分析不仅需要个人项目，但对于整个项目的数据的集成分析至关重要，因此该程序。