Multi-site Feasibility of Compassion Meditation for Veterans with PTSD

对患有创伤后应激障碍 (PTSD) 的退伍军人进行同情冥想的多地点可行性

• 批准号: 10221607
• 负责人: Ariel J Lang
• 金额: $ 63.38万
• 依托单位: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10221607
• 关键词: Address; Area; Behavioral; California; Caring; Clinical; Clinical Trials; Cognitive; Compassion; Complement; Country; Data; Development; Enrollment; Evidence based treatment; Fostering; Future; Glean; Goals; Health; Impairment; Individual; Intervention; Investigation; Laboratories; Lead; Link; Manuals; Measures; Mediating; Meditation; Methodology; Military Personnel; Monitor; Outcome; Participant; Patient Self-Report; Personal Satisfaction; Phase; Population; Post-Traumatic Stress Disorders; Preparation; Procedures; Process; Protocols documentation; Randomized; Randomized Controlled Trials; Recovery; Relaxation; Research; Role; Sampling; Site; Stress; Symptoms; Testing; Training; Translating; Veterans; Work; acceptability and feasibility; base; clinical effect; coping; efficacy trial; interest; multimodality; patient response; positive emotional state; preference; psychologic; psychosocial; randomized trial; recruit; regional difference; resilience; social; tool; treatment effect

PROJECT SUMMARY/ABSTRACT Posttraumatic stress disorder (PTSD) is a common health concern among Veterans. Although empirically-supported approaches are widely available, engagement rates are low and partial/non response is common. There has been considerable interest in the role of complementary and alternative interventions for PTSD, but little research is available to guide decisions about care. Compassion meditation (CM), a contemplative practice that is intended to foster connectedness with others, shows promise for the treatment of PTSD in Veterans. In healthy populations, CM fosters positive emotion and social connectedness, both of which are known to enhance coping and resilience in the face of extreme stress. Based on this theoretical rationale, we recently completed a two-phase proof of concept trial of CM for Veterans with PTSD. The first phase employed qualitative and quantitative procedures to iteratively refine an existing CM protocol, CBCT® (Cognitively-Based Compassion Training), for Veterans with PTSD. The second phase utilized a pilot randomized controlled trial to establish the feasibility and acceptability of a randomized trial of CM for Veterans with PTSD and to examine potential clinical impact. On the basis of promising results, the proposed project will evaluate the feasibility of a future multi-site efficacy trial of CM for PTSD. Although our prior work is an encouraging first step, key questions remain. First, our data come from a single site in Southern California. It is possible that there are regional differences in the acceptability of CM, so we plan to examine the feasibility of recruiting and retaining Veterans residing in another area as well as confirming the acceptability of the approach to a more diverse sample. Second, our previous trial relied on a single therapist, who was actively engaged in the development process. It is important to demonstrate that others can be trained to deliver the approach with fidelity and to have some confidence that our results are attributable to the protocol rather than to an individual. Finally, in the interest of ultimately understanding the way in which these interventions lead to symptom change, we will continue to refine our assessment strategy, including adding behavioral methodologies to augment what can be gleaned from self-report measures. If successful, this project will lay the necessary groundwork for an efficacy trial of CM, which ultimately could provide an additional evidence-based treatment option for Veterans with PTSD.

项目摘要/摘要 创伤后应激障碍（PTSD）是退伍军人的普遍关注 经验支持的方法已广泛可用，参与率很低，部分/非反应是 常见。 PTSD，但很少有研究可以指导有关同情心的决策。 旨在促进与他人建立联系的沉思实践，表明了治疗的保证 在健康受欢迎的退伍军人中，PTSD。 面对极端压力，已知可以增强应对和韧性。 理由，我们最近完成了CM的两阶段概念验证验证，该概念验证了PTSD的退伍军人。 相位迭代的定性和定量程序，用于改进现有的CM协议CBCT® （基于认知的同情训练），用于PTSD的退伍军人。 随机对照试验，以建立CM随机试验的可行性和可接受性 使用PTSD并根据有希望的结果检查潜在的临床影响。 评估CM对PTSD的未来多站点功效试验的可行性。 尽管我们先前的工作是令人鼓舞的第一步，但关键问题仍然是我们的数据。 南加州的单一地点可能是CM的区域差异 我们计划研究居住在另一个地区的招聘和保留退伍军人的可行性 确认方法对更多样化的样本的可接受性。 单一治疗师，积极从事开发过程。 其他人可以接受训练以忠实的态度来实现这种方法，并有一定的信心我们的结果是 归因于协议，而不是个人。 这些干预措施导致症状改变的方式，我们将继续完善我们的评估策略， 包括添加行为方法学，以增强DELF报告中的Glenery 成功，这个项目将使CM有效试验，最终可以 为使用PTSD的退伍军人提供额外的基于证据的治疗选择。