BIOENERGETICS OF EXERCISE-INDUCED MENSTRUAL DISTURBANCES

运动引起的月经紊乱的生物能量学

基本信息

批准号：
6637959
负责人：
NANCY Imboden WILLIAMS
金额：
$ 43.23万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-05-10 至 2004-04-30
项目状态：
已结题

项目摘要

DESCRIPTION: (Scanned from the applicant's abstract) The suppression of menstrual cyclicity due to strenuous exercise can cause infertility, severe bone demineralization, increase fracture risk, and possibly increase the risk of cardiovascular disease. Recent findings in humans and animals have strongly suggested that exercise-induced menstrual disturbances are primarily caused by low energy availability and not by other factors, such as the physical stress of exercise per se. While some studies have quantified energy balance associated with short-term decreases in plasma levels of reproductive hormones, the bioenergetics associated with the induction and reversal of clinically recognized menstrual disturbances in exercising women remain unclear. The first specific aim of this proposal is to test the hypothesis that there is a direct relationship between the severity of exercise-induced menstrual disturbances and the magnitude of negative energy balance. In addition to weight loss, crosssectional studies in humans suggest that exercise-induced menstrual disturbances are associated with adaptive mechanisms to conserve energy, i.e., alterations in circulating metabolic hormones and substrates, and reductions in components of 24 h energy expenditure such as metabolic rate. Since in vivo and in vitro studies using animal models have suggested mechanistic roles for key metabolic hormones and substrates in the modulation of GnRH neuronal activity with changes in energy balance, prospective studies in humans are now necessary to identify the time course and magnitudes of change of potential key metabolic signals during the development of EIMD. The second specific aim of this proposal is to test the hypothesis that exercise-induced menstrual disturbances are triggered by the development of a particular metabolic state defined by adaptive mechanisms to conserve energy. The significance of this research relates to conditions of infertility, delayed puberty, anovulation, anorexia nervosa, exercise-induced amenorrhea, and the recently identified high incidence of luteal phase disturbances and anovulatory cycles in women exercising even at recreational levels. We expect the results of these studies to provide new and useful information for making specific recommendations regarding the exercise and dietary practices concomitant with maintaining normal, ovulatory menstrual cycles and adequate levels of circulating estrogen and progesterone. The results will also expand our understanding of the mechanism of the modulation of reproductive function by energy availability.

描述：（从申请人的摘要中扫描）抑制剧烈运动导致的月经周期周期性会导致不孕，严重的骨脱矿质，增加骨折风险，并可能增加风险心血管疾病。最近在人类和动物身上的发现强烈认为运动引起的月经紊乱主要是由能量可用性低，而不是由其他因素（例如身体压力）引起锻炼本身。虽然一些研究量化了能量平衡与血浆生殖激素水平的短期下降有关，与临床上的诱导和逆转相关的生物能学运动女性中公认的月经紊乱仍不清楚。该提案的第一个具体目标是检验以下假设：运动引起的月经的严重程度与干扰和负能量平衡的程度。此外人类横断面研究表明，运动引起的体重减轻月经失调与保存的适应性机制有关能量，即循环代谢激素和底物的变化，以及减少 24 小时能量消耗的组成部分，例如代谢率。由于使用动物模型进行的体内和体外研究表明关键代谢激素和底物在调节中的机制作用 GnRH 神经元活动与能量平衡变化的前瞻性研究现在有必要确定人类的时间进程和幅度 EIMD 发展过程中潜在关键代谢信号的变化。这该提案的第二个具体目标是检验以下假设：运动引起的月经紊乱是由由适应性机制定义的特定代谢状态以保存能量。这项研究的意义涉及不孕不育、延迟生育的情况青春期、无排卵、神经性厌食、运动引起的闭经等最近发现黄体期紊乱和无排卵的发生率很高女性甚至在娱乐水平上进行锻炼的周期。我们期待结果这些研究为制定具体方案提供了新的有用信息有关运动和饮食习惯的建议维持正常的排卵月经周期和足够的水平循环雌激素和黄体酮。结果也将扩大我们的了解生殖功能调节机制能源可用性。