Training program in the neurology of language and neurodegenerative aphasias

语言神经病学和神经退行性失语症培训计划

基本信息

批准号：
10216095
负责人：
MARIA LUISA GORNO TEMPINI
金额：
$ 18.88万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10216095
关键词：
Acoustics Aging Air Algorithms Alzheimer&apos s Disease Anatomy Anomia Anterior Aphasia Area Articulation Atrophic Attention Autopsy Basic Science Behavior Therapy Behavioral Biological Markers Biomechanics Brain Caring Cessation of life Characteristics Clinical Clinical Sciences Cognitive Communication Corpus striatum structure Data Data Science Dementia Diagnosis Differential Diagnosis Disease Disease Progression Early Diagnosis Enrollment Evaluation Faculty Frontotemporal Lobar Degenerations Functional Imaging Future Goals Grant Image Impairment Institutes Knowledge Laboratories Language Language Disorders Leadership Learning Left Machine Learning Magnetic Resonance Imaging Measurement Measures Memory Mentors Methodology Methods Molecular Monitor Motor Movement Nerve Degeneration Neurodegenerative Disorders Neurologic Neurologist Neurology Neurosciences Outcome Measure Parietal Pathologic Pathologist Pathology Patients Pattern Peer Review Pharmacologic Substance Pharmacological Treatment Phenotype Positioning Attribute Predisposition Primary Progressive Aphasia Production Publications Reading Research Research Personnel Research Project Grants Resources Sampling Scientist Semantics Severities Shapes Site Speech Speech Acoustics Speech Disorders Speech Sound Structure Supervision Syndrome System Talents Techniques Technology Time Tissues Training Training Programs Translational Research Universities Update Variant automated analysis automated speech recognition brain circuitry brain health cognitive neuroscience cohort constriction diversity and equity experience improved innovation interest machine learning algorithm molecular pathology neuroimaging next generation novel patient oriented research phonology real-time images relating to nervous system response shape analysis success tau Proteins tool training opportunity treatment response treatment trial

项目摘要

This K24 grant renewal is requested to support the mentoring activities of Dr. Maria Luisa Gorno Tempini, a behavioral neurologist and cognitive neuroscientist. Dr. Gorno Tempini is a leading researcher and clinician in the fields of neurology and the neuroscience of language, with specific expertise in atypical neurodegenerative diseases that present as speech and language disorders. She mentors a talented group of clinicians and researchers to study and treat Primary Progressive Aphasia (PPA) and investigate the neural basis of language. Dr. Gorno Tempini has a proven track record of success in mentoring both clinicians and scientists in patient- oriented research (POR) related to speech and language disorders. The goals of this proposal are to support time for Dr. Gorno Tempini to mentor a growing number of increasingly diverse clinicians and researchers interested in neurodegenerative language disorders, to extend her impact as a mentor at UCSF, and to pursue novel lines of research in PPA. Leveraging the resources available at the UCSF Memory and Aging Center (MAC), the Global Brain Health Institute, and the UCSF Clinical and Translational Science Institute, she will mentor clinicians, faculty, postdoctoral scholars, and scientists with particular attention to cultivating diversity, equity, and inclusion in her laboratory, the university, and the profession at large. She will sustain her comprehensive mentoring system that features one-on-one mentoring, supervision of clinicians in patient diagnosis and care, and group mentoring activities. She will update and extend that system with opportunities for training with colleagues in speech and data science and a focus on mentoring more advanced junior colleagues as emerging mentors themselves. Dr. Gorno Tempini's experience in basic cognitive neuroscience and neurological methodologies and her increasingly nuanced leadership expertise uniquely position her to benefit a diverse group of trainees. The research project proposed here will develop automatic, efficient, and objective methods to measure speech production in PPA. The study will apply acoustic analysis scripts and automatic speech recognition to five minutes of audio recordings collected from 500 well-characterized PPA patients and employ dynamic speech MRI to identify anatomical biomarkers of vocal tract movements corresponding to speech articulation errors. This will lead to earlier detection of speech deficits; improved characterization of clinical syndromes; and more detailed, objective, and efficient outcome measures to track progression and, in the future, response to treatment. Machine learning analyses of acoustic measures and imaging data collected through other MAC projects will provide novel tools for prediction of post-mortem pathology and new knowledge on the neural basis of speech. This grant will be instrumental in supporting the pursuit of Dr. Gorno Tempini's goals to mentor the next generation of clinician scientists in the neurology of language and neurodegenerative aphasias.

请求续订 K24 赠款是为了支持玛丽亚·路易莎·戈尔诺·坦皮尼 (Maria Luisa Gorno Tempini) 博士的指导活动，她是一位行为神经学家和认知神经科学家。 Gorno Tempini 博士是一位领先的研究员和临床医生神经病学和语言神经科学领域，在非典型神经退行性疾病方面具有特定的专业知识表现为言语和语言障碍的疾病。她指导了一群才华横溢的临床医生研究人员研究和治疗原发性进行性失语症（PPA）并研究语言的神经基础。 Gorno Tempini 博士在指导临床医生和科学家治疗患者方面有着良好的记录。与言语和语言障碍相关的定向研究（POR）。该提案的目标是为 Gorno Tempini 博士提供时间来指导越来越多的日益增长的人对神经退行性语言障碍感兴趣的不同临床医生和研究人员，将她的影响扩大到加州大学旧金山分校的导师，并在 PPA 领域追求新颖的研究方向。利用现有资源加州大学旧金山分校记忆与衰老中心 (MAC)、全球脑健康研究所以及加州大学旧金山分校临床和转化科学研究所，她将指导临床医生、教师、博士后学者和科学家她特别注重在她的实验室、大学和社区中培养多样性、公平性和包容性整个职业。她将维持以一对一指导为特色的全面指导系统，监督临床医生对患者诊断和护理以及小组指导活动。她将更新并扩展该系统提供与同事进行语音和数据科学培训的机会，并注重指导更先进的初级同事本身就是新兴导师。 Gorno Tempini 博士的基础经验认知神经科学和神经学方法论以及她日益细致入微的领导专业知识使她具有独特的地位，可以使不同的学员群体受益。这里提出的研究项目将开发自动、高效、客观的语音测量方法 PPA 生产。该研究将声学分析脚本和自动语音识别应用于五个从 500 名特征明确的 PPA 患者收集了几分钟的录音，并采用动态语音 MRI 可识别与言语发音错误相对应的声道运动的解剖生物标志物。这将导致更早发现言语缺陷；改善临床综合征的特征；还有更多详细、客观和有效的结果衡量标准，用于跟踪进展情况以及未来的应对措施治疗。对通过其他 MAC 收集的声学测量和成像数据进行机器学习分析项目将为预测死后病理学和神经基础的新知识提供新工具的言语。这笔赠款将有助于支持 Gorno Tempini 博士实现指导下一代的目标一代语言和神经退行性失语症神经病学临床科学家。