Chinese Language Assessment in Primary Progressive Aphasia

原发性进行性失语症的汉语评估

• 批准号: 10437736
• 负责人: MARIA LUISA GORNO TEMPINI
• 金额: $ 19.32万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10437736
• 关键词: Address; Adopted; Affect; Aging; Alzheimer' s Disease; Anatomy; Anterior; Area; Assessment tool; Atrophic; Awareness; Brain; California; Caring; Cessation of life; Characteristics; Chinese; Chinese American; Classification; Clinical; Data; Dementia; Development; Diagnosis; Disease; English Language; Enrollment; Exhibits; Foundations; Funding; Goals; Hong Kong; Hospitals; Image; Individual; Institutes; International; Isometric Exercise; Joints; Knowledge; Language; Language Disorders; Left; Linguistics; Link; Magnetic Resonance Imaging; Measures; Medical; Medical center; Memory; Morphology; Motor; Names; Nerve Degeneration; Neurodegenerative Disorders; Orthography; Outpatients; Participant; Pathologic; Pathologist; Patients; Pattern; Perception; Performance; Phenotype; Pilot Projects; Population; Positioning Attribute; Prevalence; Primary Progressive Aphasia; Probability; Production; Progressive Nonfluent Aphasias; Quality of life; Reading; Research; Research Personnel; Research Project Grants; San Francisco; Semantics; Source; Specificity; Speech; Structure; Symptoms; Syndrome; Taiwan; Temporal Lobe; Testing; Translating; Underserved Population; United States; Universities; Validation; Variant; Visit; Visual; Work; base; brain health; caucasian American; clinical diagnosis; cohort; design; diagnostic criteria; diagnostic strategy; experience; flexibility; improved; inpatient service; insight; language impairment; neural correlate; neural network; neuroimaging; novel; phonology; relating to nervous system; therapy development; tool

PROJECT SUMMARY Primary Progressive Aphasia (PPA) is a clinical syndrome characterized by isolated progressive loss speech and language functions due to selective degeneration of language networks. Nearly all past PPA research has focused on English language speakers, even though there are an estimated 1.2 billion native Chinese speakers worldwide and 3.5 million Chinese speakers in the United States. Considering the comparable prevalence of PPA in the Caucasians and Chinese-American population, there might be more than a million Chinese PPA individuals worldwide. The majority of them remain unidentified or misdiagnosed, largely due to the lack of appropriate assessment tools and lack of awareness. Chinese-speaking PPA individuals are mainly assessed by speech and language tools translated verbatim from the English language. This is inadequate as it does not account for the profound linguistics differences between English and Chinese language. Through the joint effort of researchers, clinicians, and speech-language pathologists from the US, Taiwan, and Hong Kong, we developed a neuroanatomically-based and linguistically-adapted Chinese language assessment battery for PPA (CLAP). The CLAP battery's feasibility has been demonstrated through a pilot project funded by U.S. Alzheimer's Association and Global Brain Health Institute. The overarching goal of this project is to improve the clinical diagnosis and classification of Chinese-speaking PPA patients. This project consists of two specific aims. The first aim focuses on validating the neuroanatomical specificity of the individual tests in the CLAP battery. Through this effort, we will acquire in-depth anatomical knowledge of various neurolinguistics components in the Chinese speaking population. The second aim is designed to investigate the clinical and linguistics features of imaging-based phenotypes in our Chinese PPA cohort. Enrolled Chinese-speaking PPA individuals will be clustered into different imaging-based phenotypes based on their predominant atrophy areas. The MRI volumetric phenotypes will be compared between the Chinese-speaking and English-speaking cohorts to validate the PPA neuroimaging signatures. The clinical and linguistics features of each imaging based phenotype will be studied to identify significant key features that facilitate the diagnosis and classification of the Chinese-speaking PPA population. This project will provide novel mechanistic insights to the neural basis of language in Chinese speakers and establish specific speech and language assessment tools for the Chinese-speaking PPA population with the long-term goal of improving diagnosis and care for this underserved population. It also promotes linguistics diversity in the field of neurodegenerative disease research.

项目摘要 主要进行性失语症（PPA）是一种临床综合征，其特征是孤立的进行性损失语音 由于语言网络的选择性变性而引起的语言功能。几乎所有过去的PPA研究都有 即使估计有12亿名中语的人，专注于英语说话者 全球和350万中国发言人在美国。考虑到可比的患病率 PPA在高加索人和中国裔美国人人口中，可能有超过一百万的中国PPA 全球个人。他们中的大多数仍然不明身份或误诊，这主要是由于缺乏 适当的评估工具和缺乏意识。说中文的PPA个人主要评估 通过语音和语言工具，用英语翻译了逐字化。这是不足的 解释英语和中文之间的深刻语言学差异。通过联合努力 来自美国，台湾和香港的研究人员，临床医生和言语病理学家 为PPA开发了一种基于神经解剖学的和语言适应的中文评估电池 （拍）。拍手电池的可行性已通过美国阿尔茨海默氏症资助的试点项目证明 协会和全球脑健康研究所。 该项目的总体目标是改善说中文的临床诊断和分类 PPA患者。该项目由两个具体目标组成。第一个目的是验证神经解剖学 拍手电池中单个测试的特异性。通过这项努力，我们将获得深入的解剖学 在中文人群中了解各种神经语言学组成部分。第二个目标是 旨在研究中国PPA中基于成像的表型的临床和语言特征 队列。注册中文的PPA个人将聚集在不同的基于成像的表型中 基于它们的主要萎缩区域。将比较MRI体积表型 讲中文和英语的同类人群以验证PPA神经影像签名。临床和 将研究每个基于成像的表型的语言学特征，以识别重要的关键特征 促进说中文PPA人群的诊断和分类。 该项目将在中国说话者中为语言的神经基础提供新颖的机械见解， 为讲中文的PPA人群建立特定的语音和语言评估工具 改善对该服务不足的人群的诊断和护理的长期目标。它还促进语言学 神经退行性疾病研究领域的多样性。