Stem Cells and Aging

干细胞与衰老

基本信息

批准号：
10210266
负责人：
PETER J. QUESENBERRY
金额：
$ 189.93万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10210266
关键词：
Achievement Advisory Committees Aging American American Society of Hematology Americas Applications Grants Area Attention Biology Bone Marrow Cell Aging Cells Centers of Research Excellence Central Nervous System Diseases Chromatin Collaborations Complement Development Disease Doctor of Philosophy Educational workshop Elements Ensure Evolution Extramural Activities FOXO3A gene Faculty Fibrosis Focus Groups Fostering Foundations Funding Gerontology Goals Grant Growth Hematopoiesis Hematopoietic Hematopoietic stem cells Hospitals Individual Institutes International Medical Mentors Myelogenous Neoplasms Oncology Phase Pilot Projects Program Research Project Grants Proteins Publications Pulmonary Hypertension Recording of previous events Regulation Research Research Personnel Rhode Island Role Science Scientist Societies Stem Cell Development System Talents United States National Institutes of Health Universities Work aged career career development design experience extracellular vesicles health economics in vivo interest leukemia/lymphoma meetings member mid-career faculty multidisciplinary nerve stem cell professor programs reconstitution recruit relating to nervous system senescence stem cell aging stem cell function stem cells success symposium

项目摘要

Overall Summary/Abstract This Phase II COBRE application entitled “Stem Cells and Aging” focuses on neural and hematopoietic stem cells, their microenvironments and the impact of aging, fibrosis, and senescence on their regulation and evolution to diseases of the central nervous system and bone marrow. The COBRE continues to be led by Dr. Peter Quesenberry, but now adds Dr. John Sedivy as Associate Director Both have a long history of funded research in areas relevant to the projects in this proposal. The mentors are all outstanding and experienced investigators with significant mentoring experience and specific expertise for their mentees. Two of our previous project leaders are now mentors. The EAC consists of 4 excellent scientists who were on the last EAC and one new member focused on aging and chromatin biology. There are 4 related projects and 2 Cores. We will build on the success of our Phase I COBRE in which we saw 5 of our 6 investigators progress in their careers and 2 individuals obtained R01 funding (3 R01s), one significant DOD funding, one Leukemia /Lymphoma Society support and one other K08 support. Total extramural support obtained by our fundees (not counting COBRE dollars) for all years was $11,283,095 and total publications were 134. We plan to employ enhanced metrics to support talented investigators and sculpt their projects so that they are competitive for garnering independent NIH support. The individual projects are 1.) Patrycja Dubielecka PhD on the role of Abelson interactive protein-1 and its effect on the microenvironment in the development of myeloid neoplasia with aging, 2.) Olin Liang PhD. on the role of aged microenvironment in normal hematopoiesis, defining the critical niche cells and the role of SHIP inhibition in vivo in reconstitution of aged and preleukemic microenvironment, 3.) Jill Kreiling PhD on the study of cellular senescence and role of retrotransposable elements, and 4.) Ashley Webb PhD to determine whether changes in the FOXO3 network underlies decline of neural stem cell function with aging. The success of our PHASE I COBRE derives from our attention to mentoring junior investigators but we will enhance this with new groups focused on Academic Advancement and Promotion and on Collaborative Grants. We will maintain our approach where we insist that our junior investigators participate in weekly meetings where we rotate from investigator to investigator in terms of keeping track of progress of their individual projects. All investigators have benefited from a close relationship with their mentors, and these will continue. Our goal here is the sequential development of successful R01 grant applications. We also realize that the growth of our investigators ultimately depends upon their ability to successfully complete academic milestones necessary for promotion, retention and eventual tenure. All of our Phase II project PIs are Assistant Professors, thus their promotion to Associate Professor will require meeting Brown milestones and as part of our Brown mentoring activities we will ensure that these milestones are met. Our long-term goal will be the development of an Institute focused on stem cells and aging.

总体总结/摘要这项名为“干细胞与衰老”的二期 COBRE 应用重点关注神经干细胞和造血干细胞细胞及其微环境以及衰老、纤维化和衰老对其调节和作用的影响 COBRE 继续由 Dr. 领导。 Peter Quesenberry，但现在增加 John Sedivy 博士为副主任两人都有悠久的资助历史与本提案中的项目相关的领域的研究导师都是杰出且经验丰富的。我们的两名受训者拥有丰富的指导经验和特定的专业知识。以前的项目负责人现在是导师，由 4 位最后的优秀科学家组成。 EAC 和一名新成员专注于衰老和染色质生物学，有 4 个相关项目和 2 个核心项目。我们将在第一阶段 COBRE 的成功基础上再接再厉，我们看到 6 名研究人员中的 5 名在他们的研究方面取得了进展职业生涯和 2 人获得 R01 资助（3 个 R01）、一项重要的国防部资助、一名白血病资助 /我们的受资助者获得的淋巴瘤协会支持和另一项 K08 支持。（不包括 COBRE 美元）所有年份的费用为 11,283,095 美元，出版物总数为 134 份。我们计划采用增强的指标来支持有才华的研究人员并塑造他们的项目，以便他们获得独立 NIH 支持的竞争性项目是 1.) Patrycja Dubielecka 博士。 Abelson交互蛋白1在骨髓发育中的作用及其对微环境的影响衰老引起的肿瘤，2.) Olin Liang 博士，研究衰老微环境在正常造血中的作用，定义关键的生态位细胞以及体内 SHIP 抑制在老年和白血病前期重建中的作用微环境，3.) Jill Kreiling 博士，研究细胞衰老和逆转录转座子的作用元素，以及 4.) Ashley Webb 博士，以确定 FOXO3 网络的变化是否是我们的第一阶段 COBRE 的成功源于我们对神经干细胞功能与衰老的关注。指导初级研究人员，但我们将通过专注于学术进步的新小组来加强这一点我们将继续坚持我们的方针，即我们的初级人员。调查员参加每周一次的会议，我们在调查员之间轮流进行以下工作：跟踪其个人项目的进展所有研究人员都从密切的关系中受益。与他们的导师一起，我们的目标是成功的 R01 的连续开发。我们还意识到，研究人员的成长最终取决于他们的能力。成功完成晋升、保留和最终任职所需的学术里程碑。二期项目PI是助理教授，晋升副教授需要开会布朗大学的里程碑，作为布朗大学指导活动的一部分，我们将确保实现这些里程碑。我们的长期目标是建立一个专注于干细胞和衰老的研究所。