Stem Cells and Aging

干细胞与衰老

基本信息

批准号：
10630387
负责人：
PETER J. QUESENBERRY
金额：
$ 124.07万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2028-06-30
项目状态：
未结题

项目摘要

Overall Abstract The long-term goal of the Center of Biomedical Research Excellence (COBRE) for Stem Cells and Aging is to develop a multidisciplinary translational Center for Stem Cells and Aging Biology and Therapeutics, focusing on the underlying mechanisms and therapeutic potentials in the stem cell and aging fields. The two areas of endeavor overlap extensively, one holding the promise of tissue restoration in a wide variety of disorders while the other underlies diseases that impact everyone and leads to death. Since the start of the COBRE nine years ago 17 junior investigators have received either full projects or pilots, with 369 research articles and cumulative extramural funding of over $20,000,000 largely from NIH. Seven of these individuals are still funded while 13 have sustained or advanced in their academic fields, with three entering the Biotechnology field. Since their COBRE funding, 5 have received promotions at Brown University. The main objective of the Phase 3 COBRE is to strengthen and transition the COBRE research infrastructure into a competitive, independent and self- sustaining academic center of excellence- the Center for Stem Cells and Aging Biology and Therapeutics in 5 years. To achieve this main objective four specific aims are proposed as follows. 1) To provide strong leadership, structure and support to enhance translational stem cell and aging research, by providing critical equipment and unique expertise in flow cytometry, viral construction and extracellular isolation and characterization. 2) To facilitate and develop the Flow Cytometry, Lentivirus Construct, and the Extracellular Vesicle Cores, by evaluating and focusing the performance of the Cores toward the goal of long-term independence, sustainability, and regional growth. 3) To guide the Pilot Project Program in translational stem cell and aging related research, toward extramural funding, with expert mentorship from successful local faculty through support of the Administrative Core. 4) Enhance translational research in the Rhode Island community by encouraging and enabling collaborations between clinicians and basic researchers at the junior and senior investigator levels. Our vision is by sustaining and transitioning the established high caliber research infrastructure, we will enable clinicians working side-by-side with basic research scientists, junior investigators and senior investigators, to develop insights into diseases and disorders of stem cells and aging, leading in turn to effective clinical therapeutic approaches.

全面的抽象的生物医学研究中心卓越中心（COBRE）的长期目标是干细胞和衰老的长期目标开发一个用于干细胞和衰老生物学和治疗剂的多学科转化中心，重点干细胞和老化场中的基本机制和治疗潜力。这两个领域努力广泛重叠，一个人持有多种疾病的组织恢复的承诺，而其他影响所有人并导致死亡的疾病的基础。自从cobre九年开始 AGO 17个初级调查人员已收到完整的项目或飞行员，其中有369篇研究文章和累积 NIH的校外资金超过20,000,000美元。这些人中的七个仍是资助的，而13 在他们的学术领域持续或进步，三个进入生物技术领域。自从他们 5人的柯布尔资金已在布朗大学获得晋升。第三阶段cobre的主要目标是为了加强和过渡毛茸茸的研究基础设施为竞争，独立和自我维持卓越学术中心 - 在5 年。为了实现这一主要目标，提出了四个特定目标，如下所示。 1）提供强大的领导，通过提供关键的设备以及流式细胞仪，病毒构建以及细胞外隔离和表征方面的独特专业知识。 2）到通过促进并发展流式细胞术，慢病毒构建体和细胞外囊泡核评估和集中核心的表现朝着长期独立，可持续性，和区域增长。 3）指导转化干细胞和衰老相关研究中的试点项目计划，朝向壁外资金，并在成功的地方教师的专家指导下通过支持行政核心。 4）通过鼓励和在初级和高级研究员级别的临床医生与基础研究人员之间合作。我们的愿景是维持和过渡既定的高素质研究基础设施，我们将启用临床医生与基础研究科学家，初级研究人员和高级研究人员并肩工作，对干细胞和衰老的疾病和疾病发展见解，从而导致有效的临床治疗方法。