Stem Cells and Aging

干细胞与衰老

基本信息

批准号：
10630387
负责人：
PETER J. QUESENBERRY
金额：
$ 124.07万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2028-06-30
项目状态：
未结题

项目摘要

Overall Abstract The long-term goal of the Center of Biomedical Research Excellence (COBRE) for Stem Cells and Aging is to develop a multidisciplinary translational Center for Stem Cells and Aging Biology and Therapeutics, focusing on the underlying mechanisms and therapeutic potentials in the stem cell and aging fields. The two areas of endeavor overlap extensively, one holding the promise of tissue restoration in a wide variety of disorders while the other underlies diseases that impact everyone and leads to death. Since the start of the COBRE nine years ago 17 junior investigators have received either full projects or pilots, with 369 research articles and cumulative extramural funding of over $20,000,000 largely from NIH. Seven of these individuals are still funded while 13 have sustained or advanced in their academic fields, with three entering the Biotechnology field. Since their COBRE funding, 5 have received promotions at Brown University. The main objective of the Phase 3 COBRE is to strengthen and transition the COBRE research infrastructure into a competitive, independent and self- sustaining academic center of excellence- the Center for Stem Cells and Aging Biology and Therapeutics in 5 years. To achieve this main objective four specific aims are proposed as follows. 1) To provide strong leadership, structure and support to enhance translational stem cell and aging research, by providing critical equipment and unique expertise in flow cytometry, viral construction and extracellular isolation and characterization. 2) To facilitate and develop the Flow Cytometry, Lentivirus Construct, and the Extracellular Vesicle Cores, by evaluating and focusing the performance of the Cores toward the goal of long-term independence, sustainability, and regional growth. 3) To guide the Pilot Project Program in translational stem cell and aging related research, toward extramural funding, with expert mentorship from successful local faculty through support of the Administrative Core. 4) Enhance translational research in the Rhode Island community by encouraging and enabling collaborations between clinicians and basic researchers at the junior and senior investigator levels. Our vision is by sustaining and transitioning the established high caliber research infrastructure, we will enable clinicians working side-by-side with basic research scientists, junior investigators and senior investigators, to develop insights into diseases and disorders of stem cells and aging, leading in turn to effective clinical therapeutic approaches.

全面的抽象的干细胞和衰老生物医学卓越研究中心 (COBRE) 的长期目标是建立干细胞、衰老生物学和治疗学多学科转化中心，重点关注干细胞和衰老领域的潜在机制和治疗潜力。两个领域一项努力广泛重叠，一项有望在多种疾病中恢复组织，同时另一种是影响每个人并导致死亡的疾病。自 COBRE 启动九年来前 17 名初级研究员已收到完整项目或试点项目，共发表 369 篇研究文章，累计发表超过 20,000,000 美元的外部资金主要来自 NIH。其中 7 人仍获得资助，而 13 人在其学术领域取得持续或进步，其中三人进入生物技术领域。自从他们的在COBRE的资助下，5人获得了布朗大学的晋升。 COBRE 第 3 阶段的主要目标是加强 COBRE 研究基础设施并将其转变为具有竞争力、独立和自主的维持卓越的学术中心 - 干细胞和衰老生物学和治疗学中心 5 年。为实现这一主要目标，提出以下四个具体目标。 1）提供强有力的领导，通过提供关键设备和技术来加强转化干细胞和衰老研究的结构和支持在流式细胞术、病毒构建以及细胞外分离和表征方面拥有独特的专业知识。 2) 至促进和开发流式细胞术、慢病毒构建体和细胞外囊泡核心，通过评估并集中核心的绩效以实现长期独立性、可持续性、和区域增长。 3) 指导转化干细胞和衰老相关研究试点项目，获得校外资助，并通过成功的当地教师的专家指导以及行政核心。 4) 通过鼓励和加强罗德岛社区的转化研究促进初级和高级研究人员水平的临床医生和基础研究人员之间的合作。我们的愿景是通过维持和转变已建立的高水平研究基础设施，我们将实现临床医生与基础研究科学家、初级研究人员和高级研究人员并肩工作，深入了解干细胞疾病和病症以及衰老，进而导致有效的临床研究治疗方法。