Continuation of the Coordinating Center for the Chronic Renal Insufficiency Cohort (CRIC) Study

慢性肾功能不全队列 (CRIC) 协调中心研究的延续

• 批准号: 10207603
• 负责人: HAROLD I FELDMAN
• 金额: $ 348.16万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-28 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10207603
• 关键词: Address; Affect; American; Ancillary Study; Area; Award; Behavioral; Bioinformatics; Biological Markers; Biometry; Biosensor; Cardiovascular Diseases; Cardiovascular Manifestation; Cardiovascular system; Characteristics; Chronic Kidney Failure; Chronic Kidney Insufficiency; Clinical; Clinical Data; Clinical Research; Clinical Trials; Cohort Studies; Collaborations; Communities; Creatinine; Data; Data Analytics; Data Collection; Data Coordinating Center; Data Set; Development; Disease Pathway; Disease Progression; Elderly; End stage renal failure; Enrollment; Ensure; Etiology; Evaluation; Event; Framingham Heart Study; Funding; Goals; Health; Home; Human Resources; Individual; Infrastructure; Intervention; Investigation; Kidney; Laboratories; Laboratory Research; Leadership; Logistics; Manuscripts; Measurement; Medicine; Methods; Morbidity - disease rate; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrology; Observational epidemiology; Outcome; Paper; Participant; Pennsylvania; Phase; Phenotype; Physical activity; Population; Population Heterogeneity; Preventive therapy; Preventive treatment; Procedures; Prognosis; Proteins; Protocols documentation; Publishing; Quality Control; Quality of life; Renal function; Research; Research Design; Research Personnel; Resources; Risk Factors; Role; Sampling; Scientific Inquiry; Scientist; Serum; Site; Subgroup; Supplementation; Techniques; Technology; Time; United States National Institutes of Health; Universities; Update; Urine; cardiovascular risk factor; care costs; clinical center; clinical epidemiology; cohort; data management; data repository; data sharing; design; diabetic; disability; ethnic diversity; follow-up; functional decline; health care service utilization; high risk; innovation; insight; interest; molecular marker; non-diabetic; novel; novel strategies; organizational structure; outreach; precision medicine; programs; racial diversity; recruit; repository; tool; treatment trial

This is an application from the Center for Clinical Epidemiology and Biostatistics at the University of Pennsyl- vania to serve as the Scientific and Data Coordinating Center (SDCC) for the continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study. Chronic renal insufficiency affects over 20 million Americans with particular burden among older adults. The morbidity associated with chronic kidney disease (CKD) derives from frequent progression to end-stage renal disease (ESRD), a disproportionate risk of cardiovascular events, and other morbidities associated with disability and high costs of care. Since its inception in 2001, the CRIC Study has recruited and followed a racially and ethnically diverse cohort of over 5,000 participants with reduced kidney function from 13 clinical recruitment sites across the US. The original aim of CRIC was to establish a clinical research laboratory designed to (a) identify novel predictors of CKD progression, and (b) characterize the manifestations of cardiovascular disease and identify its risk factors among individuals with CKD. The CRIC Study has examined a broad set of etiological factors (clinical, behav- ioral, and biomarker-associated) potentially responsible for both progressive CKD and morbidities in the setting of CKD, especially those operating early in the course of CKD when progression may be forestalled. Charac- terizing relationships between these risk factors and outcomes will permit identification of high-risk subgroups with CKD, guiding enrollment into preventive treatment trials and application of preventive therapies. Over time, the scientific focus and the CRIC investigator network have broadened extensively through a highly suc- cessful ancillary studies program that has included 90 projects, mostly federally funded. To date, the CRIC Study's investigative activities have resulted in over 150 published scientific papers with many additional man- uscripts in development addressing clinical outcomes in the setting of CKD. To maximize the opportunities inherent in this unique scientific resource, the CRIC Study will, in its next phase, pursue a multifaceted strategy involving: (a) continued follow-up of the cohort and investigation of a broad ar- ray of factors associated with the progression and consequences of CKD utilizing state-of-the-art methods in biostatistics and bioinformatics; (b) the use of novel remote data collection techniques to identify trajectories of kidney function and cardiovascular risk sub-phenotypes; (c) regular data sharing with CRIC Clinical Centers to facilitate new collaborative partnerships, promote innovative scientific inquiry, and support professional devel- opment of CKD researchers; (d) facilitating disseminated analysis of CRIC data by frequent and comprehen- sive updates to the NIDDK Data Repository, supplementation of the Repository's user support activities, and robust outreach to the broader research community; (e) coordination of the goals and activities of the CRIC Study with the Kidney Precision Medicine Project and other NIH-sponsored projects; and (f) the establishment and administration of an Opportunity Pool of funds for investigators external to the CRIC study.

这是宾夕法尼亚大学临床流行病学和生物统计学中心的申请 VANIA作为慢性肾脏继续的科学和数据协调中心（SDCC） 不足群体（CRIC）研究。慢性肾功能不全会影响超过2000万美国人 老年人的负担。与慢性肾脏疾病（CKD）相关的发病率源于频繁 发展为终末期肾脏疾病（ESRD），心血管事件的不成比例风险和其他 与残疾和高昂的护理成本相关的病因。 自2001年成立以来，CRIC研究已招募并遵循了种族和种族多样的队列 来自美国13个临床招聘部位的5,000多名参与者肾功能降低。这 CRIC的最初目的是建立旨在（a）确定新颖预测指标的临床研究实验室 CKD进展，（b）表征心血管疾病的表现并确定其危险因素 在患有CKD的人中。 CRIC研究检查了一系列广泛的病因因素（临床，行为 - IORAL和生物标志物相关）在情况下可能负责进行性CKD和病态 CKD，尤其是那些在CKD过程初期运作的人可能会被阻止。特征 这些风险因素和结果之间的关系将允许识别高风险亚组 使用CKD，指导入学预防治疗试验和预防疗法的应用。超过 时间，科学重点和CRIC研究者网络通过非常成功的 凭借90个项目，主要由联邦政府资助，其中包括90个项目。迄今为止，克里奇 研究的调查活动导致了150多个发表的科学论文，并有许多其他人 开发中的用户在CKD环境中解决临床结果。 为了最大化这种独特的科学资源中固有的机会，Cric研究将在下一阶段， 采用涉及的多方面策略：（a）继续对队列的跟进，并调查广泛的AR- 与CKD的进展和后果相关的因素射线，利用最先进的方法 生物统计学和生物信息学； （b）使用新颖的远程数据收集技术来识别 肾功能和心血管风险子表型； （c）与CRIC临床中心的定期数据共享 促进新的合作伙伴关系，促进创新的科学探究，并支持专业发展 CKD研究人员的选择； （d）通过频繁和全面促进对CRIC数据的传播分析 Sive更新到NIDDK数据存储库，补充存储库的用户支持活动以及 与更广泛的研究社区的强力推广； （e）CRIC的目标和活动的协调 研究肾脏精密医学项目和其他NIH赞助的项目； （f）机构 并为CRIC研究外部的调查人员提供机会库。