Chronic Kidney Disease (CKD) Biomarkers Consortium Data Coordinating Center

慢性肾脏病 (CKD) 生物标志物联盟数据协调中心

• 批准号: 9929918
• 负责人: HAROLD I FELDMAN
• 金额: $ 58.66万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-18 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9929918
• 关键词: Address; Biological Assay; Biological Markers; Biometry; Cardiovascular Diseases; Chronic Kidney Failure; Clinical; Clinical Data; Clinical Treatment; Clinical Trials; Collaborations; Communication; Data; Data Coordinating Center; Data Set; Databases; Development; Disease Pathway; Disease Progression; Documentation; End stage renal failure; Enrollment; Epidemic; Event; Financial cost; Funding; Genomics; Geography; Grant; Healthcare Systems; Individual; Intervention; Laboratories; Leadership; Logistics; Meta-Analysis; Methodology; Morbidity - disease rate; Outcome; Outcome Measure; Patients; Phase; Pilot Projects; Proteomics; Protocols documentation; Quality Control; Randomized; Renal function; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Resources; Role; Science; Signal Transduction; Source; Structure; Teleconferences; Testing; United States; Validation; biomarker discovery; biomarker identification; biomarker panel; biomarker validation; cohort; collaborative environment; data integration; design; effective intervention; epidemiology study; high risk; meetings; member; metabolomics; mortality; multidisciplinary; novel marker; prevent; programs; quality assurance; repository; study population; success; tool; treatment trial; web site

Project Summary The proposed Scientific and Data Coordinating Center (SDCC) for the Chronic Kidney Disease (CKD) Biomarkers Consortium (BioCon) will support the scientific development and implementation of a broad array of research protocols conducted by Participating Centers and pilot grant awardees within the Consortium. The BioCon SDCC will enhance biomarker science in CKD by providing expertise and leadership in epidemiological study design, biostatistics, laboratory science, stewardship of biosample resources drawn from geographically dispersed sources, and the collaborative implementation of protocols conducted by the diverse members of the BioCon research network. The specific aims proposed by the BioCon SDCC are to: 1) enhance biomarker research in CKD by providing scientific and laboratory leadership and coordination in the design and implementation of the four broad research protocols being implemented within the BioCon Network, 2) provide biostatistical expertise and leadership to optimize research designs, outcome measures and analytical approaches to investigate biomarker-outcome relationships through analysis of single cohort datasets and through meta-analyses that harmonize data across cohorts, 3) provide the biostatistical expertise and leadership to enable integration of data across the `omics' space (e.g., metabolomics, proteomics, genomics) for deeper understanding of biomarker-outcome relationships, 4) provide comprehensive administrative and logistical support for BioCon by promoting effective communication through the coordination and support of teleconferences, meetings, subcommittees, developing and managing documentation, maintaining a website for centralized resources, and preparing standard and special reports of BioCon activities, 5) coordinate and track the transfer of data and biospecimens between members of the Consortium and relevant laboratories and repositories, as well as to establish a comprehensive database of biospecimen attributes and biomarker data for approved research protocols, 6) promote network-wide quality assurance standards, practices and tools, and engage in quality control of biospecimen assays throughout the Consortium in close collaboration with the BioCon Quality Assurance Committee, and 7) continue to support the conduct of BioCon Pilot and Feasibility Projects and the integration of findings from these pilot studies into ongoing research within the Consortium.

项目摘要 提议的慢性肾脏疾病（CKD）的科学和数据协调中心（SDCC） 生物标志物联盟（Biocon）将支持广泛阵列的科学发展和实施 由参与中心和联盟内的试点赠款获奖者进行的研究方案。这 Biocon SDCC将通过在流行病学方面提供专业知识和领导才能增强CKD中的生物标志物科学 研究设计，生物统计学，实验室科学，从地理上绘制的生物样品资源管理的管理 分散的资源以及由多元化成员进行的协作协作实施 Biocon研究网络。 Biocon SDCC提出的具体目的是：1）增强生物标志物 通过在设计中提供科学和实验室的领导和协调，在CKD中进行研究 在Biocon网络中实施的四个广泛研究协议的实施，2） 生物统计学专业知识和领导才能优化研究设计，结果度量和分析 通过分析单个队列数据集和 通过跨同类数据统一数据的荟萃分析，3）提供生物统计学专业知识和 领导能够整合“ Omics”空间的数据（例如代谢组学，蛋白质组学，基因组学） 为了深入了解生物标志物的关系，4）提供全面的行政和 通过协调和支持来促进有效的沟通，对Biocon的后勤支持 电信，会议，小组委员会，开发和管理文档，维护网站 对于集中资源，准备Biocon活动的标准和特别报告，5）协调和 跟踪财团成员和相关实验室成员之间的数据和生物测量的传递以及 存储库，以及建立一个综合的生物测量属性和生物标志物数据数据库 对于批准的研究协议，6）促进范围内的网络质量保证标准，实践和工具， 并与整个财团的生物循环测定法进行质量控制 Biocon质量保证委员会和7）继续支持Biocon飞行员的行为和可行性 这些试点研究的项目和发现的整合到财团内正在进行的研究中。