Chronic Kidney Disease (CKD) Biomarkers Consortium Data Coordinating Center

慢性肾脏病 (CKD) 生物标志物联盟数据协调中心

基本信息

批准号：
9333344
负责人：
HAROLD I FELDMAN
金额：
$ 47.09万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-18 至 2019-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9333344
关键词：
Address Biological Assay Biological Markers Biometry Cardiovascular Diseases Chronic Kidney Failure Clinical Clinical Trials Communication Data Data Coordinating Center Databases Development Disease Pathway Disease Progression Documentation End stage renal failure Enrollment Epidemic Event Financial cost Future Geography Goals Grant Healthcare Systems Intervention Kidney Diseases Laboratories Lead Leadership Logistics Methodology Monitor Morbidity - disease rate National Institute of Diabetes and Digestive and Kidney Diseases Outcome Outcome Measure Patient risk Patients Phase Pilot Projects Protocols documentation Quality Control Randomized Clinical Trials Renal function Report (document)Reporting Research Research Design Research Project Grants Resources Role Science Signal Transduction Source Structure Teleconferences Testing United States Validation biomarker discovery biomarker identification design effective intervention epidemiology study follow-up high risk implementation research interest meetings member mortality multidisciplinary novel marker professional atmosphere programs public health relevance quality assurance repository success tool web site

项目摘要

DESCRIPTION (provided by applicant): The proposed coordinating center for the CKD Biomarkers Consortium (BioCon) will support scientific development and implementation of a broad array of research protocols conducted by Participating Centers and pilot grant awardees. The BioCon Scientific and Data Coordinating Center (SDCC) will enhance biomarker science in CKD by providing expertise and leadership in epidemiological study design, biostatistics, laboratory science, stewardship of biosample resources drawn from geographically dispersed sources, and the collaborative implementation of protocols conducted by the diverse members of the BioCon research network. The specific aims of the BioCon SDCC include: 1) To enhance biomarker research in CKD by providing scientific and laboratory leadership and coordination in the design and implementation of research protocols across the CKD BioCon network, 2) To provide biostatistical expertise in research designs, outcome measures and to perform analyses for development, validation and qualification of biomarkers for CKD, 3) To provide comprehensive SDCC administrative and logistical support for CKD BioCon, promoting effective communications (within the Steering Committee, with NIDDK, with NIDDK's External Expert Panel), coordinating and supporting teleconferences, meetings, subcommittees, scientific reports, and document development and management, maintaining a website, and preparing standard and special reports of consortium activities, 4) To coordinate and track the transfer of data and biospecimens between members of the consortium and appropriate repositories, and to establish a comprehensive database of information from approved CKD BioCon protocols, 5) To promote network-wide quality assurance standards, practices and tools, and engage in quality control of biospecimen assays throughout the consortium, and 6) To develop, implement, and monitor a CKD BioCon Pilot and Feasibility Projects program, and to support the conduct of the pilot studies.

描述（由申请人提供）：拟议的CKD生物标志物联盟（Biocon）的协调中心将支持由参与中心和试点赠款获奖者进行的广泛研究方案的科学发展和实施。 Biocon科学和数据协调中心（SDCC）将通过在流行病学研究设计，生物统计学，实验室科学，从地理分散的来源中获得的生物样本资源管理的专业知识和领导来增强CKD中的生物标志物科学，以及生物源分散的来源的生物样品资源的管理以及生物研究成员的协作实施。 The specific aims of the BioCon SDCC include: 1) To enhance biomarker research in CKD by providing scientific and laboratory leadership and coordination in the design and implementation of research protocols across the CKD BioCon network, 2) To provide biostatistical expertise in research designs, outcome measures and to perform analyses for development, validation and qualification of biomarkers for CKD, 3) To provide comprehensive SDCC administrative and logistical支持CKD Biocon，促进有效的沟通（在指导委员会内，与NIDDK，与NIDDK的外部专家小组一起），协调和支持电视授课，会议，小组委员会，科学报告，文档开发和管理，并维护一个网站，并在合资群体中保持合成的标准，以协调数据的标准，4），4）存储库，并建立来自批准的CKD Biocon协议的全面信息数据库，5），5）促进全网络质量保证标准，实践和工具，并参与整个财团的Biospecimen分析的质量控制，以及6）），以开发，实施，实施和实施和执行和监控CKD Biocon Pilot和可行性计划，并支持Prots and Plite of Pyter of Pyter of Plite of Pyter of Plite and Plite and Plite of Piter of Pyt of Pyter and Pyter。