Training Program In Cellular and Molecular Medicine

细胞和分子医学培训计划

• 批准号: 10197161
• 负责人: RAJINI RAO
• 金额: $ 73.14万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10197161
• 关键词: Molecular Medicine; Training Programs

PROJECT SUMMARY/ABSTRACT The mission of the training program in Cellular and Molecular Medicine (CMM) is to prepare Ph.D. scientists for laboratory research at the cellular and molecular level on topics with a direct impact on the understanding, diagnosis, treatment and prevention of human diseases. Through a series of tailored courses, small group discussions, individualized clinical exposure and laboratory research, Ph.D. candidates of this program will receive a rigorous training in scientific research and a thorough knowledge of human biology and human diseases. Consistent with the emphasis on translational research, most CMM faculty work in clinical settings, distributed over 22 clinical and basic science departments and 4 institutes within the Johns Hopkins School of Medicine and School of Public Health. Trainers will receive mentor training and are rigorously evaluated according to criteria of merit, mentorship ability and program fit. The current program size of 121 faculty and 115 students maintains ~ 1:1 faculty-student ratio by an active process of mentor recruitment, renewal and turnover to ensure the best training environment for Ph.D. candidates. A holistic review admits 20-24 trainees from a robust pool size of ~150 training grant eligible candidates, which recently increased by 40% with a doubling of underrepresented minority applications following an evidence-based decision to remove the GRE requirement. The training program will leverage institutional funds to defray tuition charges in all years, support administration and all program activities and guarantee trainee support. The first year curriculum will begin with the intensive Introduction to Human Body course that combines hands-on dissection of the human cadaver, virtual histology labs, in-class and e-lectures, and group presentations by students. Following a basic science curriculum covering principles in molecular biology, genetics, biochemistry and cell biology, accompanied by three 10-week laboratory rotations, the year will end with Introduction to Clinical Research and Cellular and Molecular Basis of Disease that covers a spectrum of clinically and/or socially relevant disorders of the human body, completing the cycle of the year from "book to bench to bedside". Other program-specific activities will include a Grant Writing workshop, a newly developed Rigor and Reproducibility in Research (3R) course and an individualized Bench to Bedside and Back (3B) clinical experience under the direction of a clinical co- mentor in years 3-4. The program sponsors an Annual Retreat, journal club and student-run research in progress seminar series. Structured career training opportunities in teaching and non-academic tracks (OPTIONS) are built into the curriculum requirements and graduates pursue diverse research careers including academic faculty (20%), industry (31%), physician scientists (19%), government (6%), business, policy or as postdoctoral fellows. Attrition rates are low (5.5%) and time to graduation has averaged 5.7 years. In summary, CMM has the experience, resources and talent to innovate in graduate education and supply the biomedical workforce with Ph.D. graduates rigorously trained to meet current and future needs.

项目摘要/摘要 细胞和分子医学培训计划（CMM）的任务是准备博士学位。科学家 在细胞和分子水平上对主题的实验室研究，直接影响理解， 人类疾病的诊断，治疗和预防。通过一系列量身定制的课程，小组 讨论，个性化的临床暴露和实验室研究，博士学位该计划的候选人将 在科学研究中接受严格的培训以及对人类生物学和人类的透彻知识 疾病。与对转化研究的重视一致，大多数CMM教师在临床环境中工作， 在约翰·霍普金斯学校的22个临床和基础科学部门以及4家学院分发 医学和公共卫生学院。培训师将接受导师培训，并经过严格评估 根据功绩的标准，指导能力和计划合适。当前的计划规模为121位教职员工 115名学生通过积极的导师招聘，更新和 营业额确保博士学位的最佳培训环境候选人。整体评论接纳了20-24名学员 从〜150培训赠款的稳健池规模中，候选人最近增加了40％ 在基于循证的决定删除GRE之后，代表性不足的少数申请倍增了一倍 要求。培训计划将利用机构资金来支付所有年份的学费，支持 管理和所有计划活动并保证受训者的支持。第一年课程将从 人体课程的密集介绍结合了人类尸体的动手解剖， 虚拟组织学实验室，课堂和电子讲座以及学生的小组演讲。遵循基础科学 课程涵盖分子生物学，遗传学，生物化学和细胞生物学的原理，并伴有 三个为期10周的实验室轮换，这一年将以临床研究和细胞和细胞的介绍结束 疾病的分子基础，该疾病涵盖了人类的临床和/或社会相关疾病的一系列疾病 身体，完成了从“书籍到长凳再到床边”一年的周期。其他特定计划的活动将 包括赠款写作研讨会，新开发的严格和研究（3R）课程的可重复性和 在临床共同的指导下，一个个性化的长凳到床边和背部（3B）临床经验 3 - 4年的导师。该计划发起了年度务虚会，期刊俱乐部和学生经营的研究 进度研讨会系列。教学和非学术轨道的结构化职业培训机会 （选项）内置在课程要求中，毕业生从事各种研究职业，包括 学术教师（20％），行业（31％），医师科学家（19％），政府（6％），商业，政策或AS 博士后研究员。流失率很低（5.5％），毕业时间平均为5。7年。总之， CMM具有在研究生教育方面创新并提供生物医学的经验，资源和人才 博士学位的劳动力毕业生经过严格的培训，以满足当前和未来的需求。