Transport ATPases: From Molecules to Maladies

运输ATP酶：从分子到疾病

• 批准号: 7908312
• 负责人: RAJINI RAO
• 金额: $ 0.75万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7908312
• 关键词: ATP phosphohydrolase; Acid-Base Equilibrium; Antineoplastic Agents; Applications Grants; Attention; Biochemistry; Biogenesis; Catalysis; Cations; Cell membrane; Cellular biology; Chemotherapy-Oncologic Procedure; Cholesterol; Collaborations; Communicable Diseases; Computational Biology; Copper; Development; Diabetic ulcer; Disabled Persons; Discipline; Disease; Drug Transport; Drug resistance; Drug usage; Enzymes; Fellowship; Fostering; Future; Gastric ulcer; Genetic Medicine; Goals; Health; Heart Diseases; Heart failure; Hereditary Disease; Human Pathology; Human body; Immune; Ions; Lead; Life; Lipids; Liver; Malignant Neoplasms; Membrane; Mentors; Metabolic; Mitochondrial Diseases; Movement; Multi-Drug Resistance; Names; Nanotechnology; Nerve Degeneration; Occupations; Orphan; Parkinson Disease; Participant; Pharmaceutical Preparations; Pharmacology; Process; Public Health; Pump; Research; Research Personnel; Role; Scientist; Site; Sodium Chloride; Structure; Technology; Trace metal; Treatment Failure; Vesicle; Vision; Water Movements; Work; Writing; hearing impairment; member; metalloenzyme; novel strategies; posters; skin disorder; solute; symposium; trafficking

DESCRIPTION (provided by applicant): The FASEB Summer Conference entitled, "Transport ATPases: From Molecules to Maladies" will bring together approximately 150 investigators from diverse scientific disciplines, including structural and computational biology, genetics and medicine, cell biology, biochemistry and pharmacology, to discuss exciting new developments relating to ion and solute pumps from June 6-11, 2010 at Snowmass Village, CO. The goal of the conference will be the timely integration of different lines of research on this topic for a deep, mechanistic understanding of human pathologies, paving the way for new therapies and advances in nanotechnology. An impetus for the conference is the rapidly growing number of diseases associated with Transport ATPases, among them: cancer and drug resistance, heart disease, immune and infectious diseases, ulcers, diabetes, vision and hearing loss, neurodegeneration and mitochondrial diseases. Sessions will include Rotary Catalysis, Structure and Mechanism of ATPases, Membrane Dynamics and Vesicle Fusion, Orphan ATPases, Transport ATPases and Cancer, Biogenesis, turnover and trafficking of ATPases. All major classes of Transport ATPases (P, V, F and ABC-type) will be covered, ranging in substrate from cations (H+, Na+, K+, Ca2+, Cu+) to hydrophobic drugs, cholesterol and lipids. Several speakers will be junior investigators and a Young Investigator's Forum will include selected talks from poster presentations. There will be two mentoring sessions for junior investigators: Resume building and Job searches, and Writing a Fellowship or Grant application. Special attention will be given to increase diversity among participants and the conference site will be accessible to persons with disabilities. The conference will provide ample opportunities for collegial discussions, stimulate new ideas and collaborations and foster future research on these important enzymes and metabolic engines. This is the only conference that unites scientists working in disparate fields on the sole and common topic of Transport ATPases. Project Narrative Relevance of the Conference to Public Health: Transport ATPases are essential for life and good health. They work as nanomotors or metabolic engines, producing virtually all the ATP used to fuel active processes in the human body. Other members control acid-base balance, salt and water movements within, outside and across cell membranes. Still others control the movement of trace metals, like copper into metalloenzymes. In cancer, chemotherapy often leads to increased activity of drug transporting ATPases, leading to multidrug resistance and failure of treatment. Other transport ATPases are defective in a host of genetic disorders, including a form of Parkinsons, liver and skin disease, vision and hearing loss, to name a few. Some are targets of drugs used to treat heart failure and stomach ulcers. Thus, bringing together researchers who use very different approaches to study Transport ATPases will lead to a better understanding of their role in disease and offer new approaches in treatment and technology.

描述（由申请人提供）：FaseB夏季会议的标题为“运输Atpases：从分子到疾病”，将使大约150名来自多元化科学学科的研究者，包括结构和计算生物学，遗传学和医学，细胞生物学，生物学，生物化学和药物学，以讨论令人兴奋的新发展，以讨论令人兴奋的新发展，从而在6月6日的群落中，共同宣布了6月1日的群体，该赛季是6-11，从6月1日开始，该群落是6-11。及时整合有关该主题的不同研究线，以深入，对人类病理的深刻理解，为纳米技术的新疗法和进步铺平道路。会议的推动力是与运输ATPase相关的迅速增长的疾病，其中包括癌症和耐药性，心脏病，免疫和传染病，溃疡，糖尿病，视力和听力丧失，神经变性和线粒体疾病。会议将包括ATPases的旋转催化，结构和机制，膜动力学和囊泡融合，孤儿ATPases，Transping ATPases和Cancer，生物发生，周转和ATPases的运输。所有主要类别的运输ATPases（P，V，F和ABC型）都将被覆盖，从阳离子（H+，Na+，K+，Ca2+，Cu+）到疏水性药物，胆固醇和脂质的基板范围。几位演讲者将是初级调查员，一个年轻的调查员论坛将包括海报演讲中的精选演讲。初级调查人员将有两个指导会议：简历建设和求职，以及撰写奖学金或赠款申请。将特别注意增加参与者之间的多样性，而残疾人将可以接触会议现场。该会议将为大学讨论提供足够的机会，刺激新思想和合作，并促进对这些重要酶和代谢发动机的未来研究。这是唯一将在不同领域工作的科学家团结在运输ATPases的唯一和共同主题的会议上。 项目叙述 会议与公共卫生的相关性：运输ATPASE对生活和健康至关重要。它们是纳米运动器或代谢发动机的工作，几乎可以生产用于促进人体活跃过程的所有ATP。其他成员控制酸碱，盐和水的平衡，外部和跨细胞膜。还有一些人控制着痕量金属的运动，例如铜进入金属酶。在癌症中，化学疗法通常会导致药物运输ATPase的活性增加，从而导致多药耐药性和治疗失败。其他运输ATPase在许多遗传疾病中有缺陷，包括帕金森一家，肝脏和皮肤疾病，视力和听力损失，仅举几例。有些是用于治疗心力衰竭和胃溃疡的药物的靶标。因此，将使用截然不同的方法研究运输ATPASE的研究人员聚集在一起，将使他们在疾病中的作用有更好的了解，并在治疗和技术方面提供新的方法。