2016 Membrane Transport Proteins: Translating Molecules to Medicine Gordon Research Conference and Seminar

2016膜转运蛋白：将分子转化为药物戈登研究会议及研讨会

基本信息

批准号：
9193325
负责人：
RAJINI RAO
金额：
$ 2万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-06-11 至 2017-06-10
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9193325
关键词：
3-Dimensional Academia Accounting Address Anniversary Autistic Disorder Basic Science Big Data Biochemical Biogenesis Biological Carrier Proteins Cells Cessation of life Chemicals Climate Collaborations Communities Data Defect Development Diabetes Mellitus Discipline Disease Diuretics Drug Design Drug Targeting Employee Strikes Ensure Environment Europe Face Fluoxetine Fostering Funding Future Gender Genes Genetic Glucose Transporter Goals Government Health Hereditary Disease Hour Human Human Genome Industry Institution International Ion Channel Ion Pumps Ions Italy Lead Leadership Life Link Location Malignant Neoplasms Mediation Medicine Membrane Transport Proteins Mental Depression Mentors Metabolic Diseases Mind Mining Minority Mission Molecular Molecular Chaperones Mucolipidoses National Institute of Neurological Disorders and Stroke Neurotransmitters Nutrient Omeprazole Organism Organoids Orphan Participant Patients Persons Pharmaceutical Preparations Pharmacology Physiology Policies Postdoctoral Fellow Productivity Proton Pump Publishing Rare Diseases Recruitment Activity Regulation Reporting Research Research Personnel Resolution SK-Furosemide SLC12A3 gene Schizophrenia Science Scientist Selective Serotonin Reuptake Inhibitor Senior Scientist Site Stem cells Structure Students Syndrome System Techniques Technology Therapeutic Time Translating Translational Research Transmembrane Transport Ulcer Underrepresented Groups Underrepresented Minority Variant Vermont Woman Work base career clinically relevant cost design disability disease phenotype drug development graduate student human disease induced pluripotent stem cell inhibitor/antagonist innovation insight lectures member nervous system disorder notch protein parity peer peer coaching posters professional atmosphere professor serotonin transporter single molecule skills solute stem cell technology success symposium therapeutic target trafficking virtual

3-Dimensional Academia Accounting Address Anniversary Autistic Disorder Basic Science Big Data Biochemical Biogenesis Biological Carrier Proteins Cells Cessation of life Chemicals Climate Collaborations Communities Data Defect Development Diabetes Mellitus Discipline Disease Diuretics Drug Design Drug Targeting Employee Strikes Ensure Environment Europe Face Fluoxetine Fostering Funding Future Gender Genes Genetic Glucose Transporter Goals Government Health Hereditary Disease Hour Human Human Genome Industry Institution International Ion Channel Ion Pumps Ions Italy Lead Leadership Life Link Location Malignant Neoplasms Mediation Medicine Membrane Transport Proteins Mental Depression Mentors Metabolic Diseases Mind Mining Minority Mission Molecular Molecular Chaperones Mucolipidoses National Institute of Neurological Disorders and Stroke Neurotransmitters Nutrient Omeprazole Organism Organoids Orphan Participant Patients Persons Pharmaceutical Preparations Pharmacology Physiology Policies Postdoctoral Fellow Productivity Proton Pump Publishing Rare Diseases Recruitment Activity Regulation Reporting Research Research Personnel Resolution SK-Furosemide SLC12A3 gene Schizophrenia Science Scientist Selective Serotonin Reuptake Inhibitor Senior Scientist Site Stem cells Structure Students Syndrome System Techniques Technology Therapeutic Time Translating Translational Research Transmembrane Transport Ulcer Underrepresented Groups Underrepresented Minority Variant Vermont Woman Work base career clinically relevant cost design disability disease phenotype drug development graduate student human disease induced pluripotent stem cell inhibitor/antagonist innovation insight lectures member nervous system disorder notch protein parity peer peer coaching posters professional atmosphere professor serotonin transporter single molecule skills solute stem cell technology success symposium therapeutic target trafficking virtual

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项目摘要

The 2016 Gordon Research Conference on Membrane Transporters titled “Translating Molecules to Medicine” will bring an urgently needed translational focus to research on clinically relevant and highly druggable membrane transporters. Although they account for 10% of the human genome and contribute to a gamut of highly prevalent (autism, diabetes) as well as orphan and rare diseases (Mucolipidosis type 4, Christianson syndrome), membrane transporters remain largely untapped in their potential as therapeutic targets. The nine scientific sessions are highly interdisciplinary, bringing together topics and techniques that are not conventionally related: these include stem cell technology, 3D organoids, virtual mining of the chemical universe for inhibitors, and single molecule dynamics, as examples. Ample discussion time after each talk, daily poster sessions and afternoon free time allow plenty of opportunity for informal discussion, networking and forming new collaborations. A special Pharma session will help build consortia between industry and academics to tackle challenges in the drug development pipeline. The Keynote session will feature the GRC Alexander M. Cruickshank Lecture awardee, Dr. Nieng Yan, whose recent landmark high-resolution structures of human glucose transporters have captured the challenges and opportunities of this membrane transporter field. Approximately 150 participants will be drawn from industry, academia, research institutions and government and will span all career levels, ranging from early career investigators (graduate students, postdoctoral fellows) projected to comprise 50% of attendees, to mid-career and senior scientists and professors. This mix offers an ideal opportunity for vertical and peer mentoring, and networking, essential for the future health and productivity of this field. For the first time, we will host a pre-conference Graduate Research Seminar organized by, and exclusively for, young investigators. The GRS will include poster sessions, short talks and a Careers Panel with invited leaders from pharma, academia and publishing sectors, with a goal of fostering scientific and professional development and instilling confidence and leadership skills in student trainees and fellows. The organizers are committed to promote diversity and inclusion of women, minorities and persons of disability. To this end, our goal is to achieve gender parity (50%) in speakers and discussion leaders, and to increase the visibility of all underrepresented groups. Another innovative feature of this conference, the Power Hour, is a forum designed to address challenges that women face in science. To foster international reach, participants have elected to alternate the location of the conference between the US and Europe. Most recently, the conference was held in Vermont, and in 2016 the venue is Italy. The GRC provides seed money and negotiates costs directly with the conference site, to keep expenses at a minimum. This application seeks partial funding to cover registration costs for invited speakers, including women and minorities, and young investigators.

2016年戈登膜转运者研究会议，标题为“将分子翻译成医学” 将迫切需要翻译重点来研究临床相关和高度吸毒膜转运蛋白。尽管它们占人类基因组的10％，并有助于一系列高度普遍（自闭症，糖尿病）以及孤儿和稀有疾病（粘膜脂肪性病4型，克里斯蒂安森综合征），膜转运蛋白在其治疗靶标的潜力中基本上仍未开发。九科学会议是高度跨学科的，将不是常规相关：其中包括干细胞技术，3D器官，化学物质的虚拟采矿抑制剂和单分子动力学的宇宙作为示例。每次谈话后的充分讨论时间，每日海报会议和下午的空闲时间为非正式讨论和网络提供了足够的机会并建立新的合作。特别的制药会议将有助于在行业之间建立财团在药物开发管道中应对挑战的学者。主题演讲将具有GRC 亚历山大·Cruickshank（Alexander M. 人类葡萄糖转运蛋白捕获了该膜转运蛋白的挑战和机遇场地。大约有150名参与者来自行业，学术界，研究机构以及政府并将跨越所有职业水平，从早期职业调查员（研究生，博士后研究员）预计将占参与者的50％，职业生涯和高级科学家以及教授。这种组合为垂直和同伴的心理和网络提供了理想的机会，对该领域的未来健康和生产力。我们第一次将举办会议前毕业生研究研讨会由年轻研究人员组织，仅由年轻研究人员组织。 GRS将包括海报会议，简短的会谈以及与制药，学术界和出版部门的邀请领导人的职业小组旨在促进科学和专业发展，并在学生学员和研究员。组织者致力于促进妇女的多样性和包容，少数群体和残疾人。为此，我们的目标是在演讲者和讨论领导者，并提高所有代表性不足的群体的可见性。另一个创新特征的特征这次会议是电力时光，是一个论坛，旨在应对女性在科学领域面临的挑战。到寄养国际覆盖范围，参与者已选择替代美国之间的会议地点和欧洲。最近，该会议在佛蒙特州举行，2016年的场地是意大利。 GRC 提供种子货币并直接与会议地点进行谈判成本，以最少保留费用。该申请寻求部分资金，以支付包括妇女在内的受邀发言人的注册费用少数民族和年轻的调查员。