Toward an animal model of visual simulation

视觉模拟的动物模型

• 批准号: 10195217
• 负责人: DAVID L SHEINBERG
• 金额: $ 23.25万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10195217
• 关键词: Animal Model; Animals; Area; Behavioral; Brain; Data; Data Set; Disease; Event; Eye; Functional Magnetic Resonance Imaging; Future; Goals; Hallucinations; Human; Imagery; Imagination; Individual; Instruction; Investigation; Life; Link; Measures; Methods; Microelectrodes; Mind; Modeling; Monkeys; Motion; Motion Perception; Motor; Movement; Nature; Neurons; Neuropsychology; Outcome; Parietal; Participant; Pattern; Perception; Performance; Play; Positioning Attribute; Post-Traumatic Stress Disorders; Process; Prosthesis; Protocols documentation; Psyche structure; Psychophysics; Reaction Time; Research; Scanning; Schizophrenia; Sensory; Stimulus; Support System; Testing; Training; Visual; Visual Hallucination; Visual system structure; Visualization; Work; awake; clinically significant; daily functioning; experience; experimental study; extrastriate visual cortex; human subject; imaging study; mental function; mental imagery; nervous system disorder; neural circuit; neuroimaging; neuromechanism; neurophysiology; nonhuman primate; novel; object motion; recruit; relating to nervous system; simulation; social cognition; temporal measurement; tool; visual imagery; visual processing

Abstract/Summary The goal of this project is to develop an animal model for visual simulation. In particular, we aim to show that animals, like humans, can engage in extended visualization of events not present in the external world. This capacity is essential, as it allow animals to test strategies and reason about the world using internal visual machinery. Until now, almost all exploration of visual simulation has been carried out in humans, as verbal instructions are the most common way to evoke controlled imagined experiences. Here we introduce a novel task, initially tested in humans, to non-human primate subjects. In Aim 1, we will show that their performance in this task mirrors that of human subjects. We will then have these trained animal subjects participate in awake fMRI studies while performing this task, and associated controls, in order to test the hypothesis that the same visual circuits involved in active perception of dynamic visual events are recruited during internally driven visual simulation of these events (Aim 2). Successful completion of these aims will provide a key starting point for the first systematic neurophysiological investigations of visual mental simulation at the single neuron level. This has significant implications for understanding the rich interplay between the visual system and higher mental function in both normal perception and neurological disease.

摘要/摘要 该项目的目的是开发一种用于视觉模拟的动物模型。特别是，我们的目的是展示 像人类一样，动物可以进行外部世界中不存在的事件的扩展可视化。 这种能力是必不可少的，因为它允许动物使用内部测试世界的策略和理性 视觉机械。到目前为止，几乎所有对视觉模拟的探索都是在人类中进行的，因为 言语说明是唤起受控经历的最常见方法。在这里，我们介绍 最初在人类中测试的一项新型任务，是针对非人类灵长类动物的。在AIM 1中，我们将证明他们的 在此任务中的表现反映了人类受试者的表现。然后，我们将拥有这些训练有素的动物对象 在执行此任务和相关控件时，参加清醒的fMRI研究，以测试 假设募集了参与动态视觉事件的主动感知的相同视觉电路 在内部驱动的这些事件的视觉模拟过程中（AIM 2）。这些目标的成功完成将 为视觉心理进行首次系统的神经生理研究提供了关键的起点 单个神经元水平的模拟。这对理解丰富的相互作用具有重要意义 在正常感知和神经系统疾病中，视觉系统和较高的心理功能之间。