Toward an animal model of visual simulation

视觉模拟的动物模型

基本信息

批准号：
10195217
负责人：
DAVID L SHEINBERG
金额：
$ 23.25万
依托单位：
BROWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-05-01 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10195217
关键词：
Animal Model Animals Area Behavioral Brain Data Data Set Disease Event Eye Functional Magnetic Resonance Imaging Future Goals Hallucinations Human Imagery Imagination Individual Instruction Investigation Life Link Measures Methods Microelectrodes Mind Modeling Monkeys Motion Motion Perception Motor Movement Nature Neurons Neuropsychology Outcome Parietal Participant Pattern Perception Performance Play Positioning Attribute Post-Traumatic Stress Disorders Process Prosthesis Protocols documentation Psyche structure Psychophysics Reaction Time Research Scanning Schizophrenia Sensory Stimulus Support System Testing Training Visual Visual Hallucination Visual system structure Visualization Work awake clinically significant daily functioning experience experimental study extrastriate visual cortex human subject imaging study mental function mental imagery nervous system disorder neural circuit neuroimaging neuromechanism neurophysiology nonhuman primate novel object motion recruit relating to nervous system simulation social cognition temporal measurement tool visual imagery visual processing

项目摘要

Abstract/Summary The goal of this project is to develop an animal model for visual simulation. In particular, we aim to show that animals, like humans, can engage in extended visualization of events not present in the external world. This capacity is essential, as it allow animals to test strategies and reason about the world using internal visual machinery. Until now, almost all exploration of visual simulation has been carried out in humans, as verbal instructions are the most common way to evoke controlled imagined experiences. Here we introduce a novel task, initially tested in humans, to non-human primate subjects. In Aim 1, we will show that their performance in this task mirrors that of human subjects. We will then have these trained animal subjects participate in awake fMRI studies while performing this task, and associated controls, in order to test the hypothesis that the same visual circuits involved in active perception of dynamic visual events are recruited during internally driven visual simulation of these events (Aim 2). Successful completion of these aims will provide a key starting point for the first systematic neurophysiological investigations of visual mental simulation at the single neuron level. This has significant implications for understanding the rich interplay between the visual system and higher mental function in both normal perception and neurological disease.

摘要/总结该项目的目标是开发用于视觉模拟的动物模型。特别是，我们的目标是展示动物和人类一样，可以对外部世界中不存在的事件进行扩展的可视化。这种能力至关重要，因为它允许动物测试策略并利用内部推理来推理世界视觉机械。到目前为止，几乎所有视觉模拟的探索都是在人类身上进行的，例如口头指示是唤起受控想象体验的最常见方式。这里我们介绍一下这是一项新颖的任务，最初在人类身上进行了测试，后来又在非人类灵长类动物身上进行了测试。在目标 1 中，我们将证明他们这项任务的表现反映了人类受试者的表现。然后我们将拥有这些训练有素的动物受试者在执行此任务时参与清醒的功能磁共振成像研究以及相关的控制，以测试假设涉及动态视觉事件的主动感知的相同视觉回路被招募在这些事件的内部驱动的视觉模拟期间（目标 2）。成功完成这些目标将为视觉心理的首次系统神经生理学研究提供了关键起点单神经元水平的模拟。这对于理解丰富的相互作用具有重要意义正常知觉和神经系统疾病中视觉系统和高级心理功能之间的关系。