1Florida Alzheimer's Disease Research Center Data Management and Statistical (DMS) Core

1佛罗里达阿尔茨海默病研究中心数据管理和统计 (DMS) 核心

• 批准号: 10190774
• 负责人: MICHAEL MARSISKE
• 金额: $ 20.68万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10190774
• 关键词: Algorithms; Alzheimer' s Disease; Big Data; Biological Markers; Biometry; Catalogs; Clinical; Clinical Trials; Code; Collaborations; Communities; Competence; Computer software; Consultations; Data; Data Analyses; Data Collection; Data Management Resources; Data Security; Data Set; Database Management Systems; Dementia; Development; Diagnosis; Documentation; Ensure; Equation; Equipment and supply inventories; Fiber; Florida; Geography; Growth; Language; Leadership; Link; Logistic Regressions; Maintenance; Manuscripts; Measures; Methods; Modeling; Participant; Peer Review; Process; Publications; Pythons; Quality Control; Reproducibility; Research; Research Design; Research Personnel; Research Support; Secure; Source Code; Statistical Data Interpretation; Statistical Methods; Structure; System; Training Activity; Trust; Validation; Work; biomedical informatics; career; data acquisition; data collection site; data exchange; data handling; data management; data repository; distributed data; eHealth; education research; longitudinal analysis; machine learning algorithm; multilevel analysis; neuroimaging; novel; open data; open source; operation; phenotypic data; power analysis; repository; sound; statistics; tool

Summary/Abstract: Data Management and Statistical Core, 1Florida ADRC The Data Management and Statistical Core of the 1Florida ADRC functions as key connective fiber that links the various cores of the center, provides the principal point of contact with internal and external investigators and trainees, and is the primary conduit to the National Alzheimer’s Coordinating Center (NACC), both for the delivery of data, and for the acquisition of data sets for local investigators. The Core also exists to ensure rigor and reproducibility at every step of data handling, from entry and coding, through analysis and dissemination. Consistent with the central themes of the 1Florida ADRC, the Core (a) consolidates, de-identifies and provides biomarker data to investigators, (b) puts particular emphasis on data analysis methods for longitudinal analysis, particularly in supporting and educating early career investigators in their use, (c) supports biomedical informatics and e-health investigators in accessing and using large data repositories (e.g., the One Florida Data Trust) for development of novel hypotheses regarding dementias. The core also provides leadership in the collaborative development of open source applications for the coding and transmission of data. Aims of the Core include: (1) providing high quality data management processes and systems to data that has been validated, integrated/merged (across Center operations), is secure, well documented, and shared with other investigators locally and nationally; (2) providing up-to-date data analysis consultation in a) study design, b) selection of study measures, c) data analysis, d) interpretation of findings, and e) presentation, before, during and after data collection and analysis. The core also ensures rigor and reproducibility of 1Florida ADRC research by supporting (a) pre-registration of manuscripts, (b) use of reproducible and open source code for data analyses, (c) use of preprint publication of manuscripts for wide dissemination and “open peer review”. (3) supporting the larger community of ADRC investigators nationally, and those affiliated with the 1Florida ADRC, with open source data management tools and applications; as well as with 42 online training modules (with practice data sets and code), via the Research Education Component, in methods ranging from simple descriptive to advance growth and survival models.

摘要/摘要：数据管理和统计核心，1Florida ADRC 1Florida ADRC 的数据管理和统计核心充当链接的关键连接光纤 该中心的各个核心，提供与内部和外部调查人员的主要联系点 学员，并且是国家阿尔茨海默病协调中心 (NACC) 的主要渠道，两者均用于交付 数据以及为当地调查人员获取数据集的目的也是为了确保严谨性和有效性。 从输入和编码到分析和传播，数据处理的每个步骤都具有可重复性。 与第 1 届佛罗里达 ADRC 的中心主题一致，核心 (a) 整合、去识别化并提供 向研究人员提供生物标志物数据，(b) 特别强调纵向分析的数据分析方法， 特别是在支持和教育早期职业研究者的使用方面，(c) 支持生物医学信息学 和电子卫生调查人员访问和使用大型数据存储库（例如，One Florida Data Trust） 该核心还提供了协作方面的领导力。 开发用于数据编码和传输的开源应用程序的核心目标包括： (1) 对已验证的数据提供高质量的数据管理流程和系统， 集成/合并（跨中心运营），安全，有据可查，并与其他调查人员共享 地方和全国； (2) 在 a) 研究设计、b) 研究措施的选择、c) 数据方面提供最新的数据分析咨询 分析，d) 对结果的解释，以及 e) 在数据收集和分析之前、期间和之后的呈现。 该核心还通过支持 (a) 预注册来确保 1Florida ADRC 研究的严谨性和可重复性 手稿，(b) 使用可复制的开源代码进行数据分析，(c) 使用预印本出版物 手稿进行广泛传播和“公开同行评审”。 (3) 支持全国范围内更广泛的 ADRC 调查员群体以及隶属于 1Florida 的调查员群体 ADRC，具有开源数据管理工具和应用程序； 42 个在线培训模块（带有实践数据集和代码），通过研究教育部分， 方法范围从简单的描述性到先进的生长和生存模型。