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促进研究人员多样性的补充

• 批准号: 10177684
• 负责人: Christina Porucznik
• 金额: $ 6.12万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2021-08-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177684
• 关键词: Address; Adolescent; Adoption; Affect; Age; Air Pollutants; Air Pollution; Area; Asthma; Behavior; Biological; Birth; Body Image; Body Size; Body Weight; Body Weight decreased; Caring; Cessation of life; Chemical Exposure; Child; Child Development; Child Health; Childhood; Cohort Studies; Communities; Conceptions; Data; Dental Enamel; Development; Diet; Disease; Eating Disorders; Endocrine Disruptors; Endocrine disruption; Enrollment; Environment; Environmental Exposure; Environmental Risk Factor; Exercise; Family; Fertilization; Food; Future; Generations; Genome; Genomics; Grant; Growth; Guidelines; Health; Health Benefit; Health Promotion; Health behavior; Healthcare; Home environment; Human Development; Hyperlipidemia; Hypertension; Immune response; Incidence; Individual; Infection; Infectious Agent; Inflammatory; Inherited; Insulin Resistance; Intervention; Language; Learning; Life; Life Style Modification; Measurement; Measures; Mental Health; Methods; Morbidity - disease rate; National Children' s Study; Nitrogen Oxides; Nutrient; Obesity; Operative Surgical Procedures; Outcome; Overweight; Ozone; Parents; Participant; Particulate; Pediatric cohort; Persons; Pharmaceutical Preparations; Phase; Physical Fitness; Physical activity; Pollution; Pregnancy; Proteome; Public Health; Recommendation; Reporting; Research; Respiratory Tract Infections; Schools; Self Efficacy; Siblings; Social Characteristics; Socioeconomic Status; Stigmatization; Structure; Time; Translating; Utah; Validation; Viral Antibodies; Weight; Work; Writing; base; bisphenol A; body dissatisfaction; bullying; cohort; cost effective; design; early childhood; early life exposure; early pregnancy; epigenome; evidence base; implantation; improved; innovation; instrument; member; microbiome; mortality; novel; nutrition; obesity in children; parent grant; phthalates; physical conditioning; physical inactivity; population based; prenatal; programs; respiratory health; response; self esteem; social stigma; therapy design; weight loss program

Project Summary/Abstract (parent grant) Early exposures in critical developmental windows around fertilization, implantation, and during pregnancy can have long-term impact on health, development, and disease in children. A comprehensive assessment of early exposures requires a multidimensional assessment of the exposome, including community-level environmental factors (including air pollution), chemical exposures (including endocrine disruptors), the microbiome (including commensals and infectious agents with associated immune responses), and the genome and its responses to the environment (including the inherited epigenome, genomic expression, and the proteome). We are currently re-enrolling a pediatric cohort from two birth cohorts enrolled peri- conceptionally/prenatally, 1) the Utah participants in the National Children’s Study, and 2) participants in the Home Observation of Peri-conceptional Exposures (HOPE) study, into the Early Life Exposures and Child Trajectories (ELECT) cohort. We are also enrolling biological parents and up to one biological sibling child. In the UG3 phase (the first two years), we focus on completing re-enrollment of the entire cohort, and also on innovative methods for assessment of a spectrum of known and emerging exposures during the key early windows of the peri-conceptional time and early pregnancy. Exposures we assess will include the microbiome, medications, infections, pan-viral antibody assessment, air pollutants (especially particulate pollution (PM2.5), also nitrogen oxides and ozone), endocrine disrupting chemicals (particularly bisphenol-A (BPA) and phthalates), and hypomineralization of dental enamel as a marker for early endocrine disrupting exposure. We will also conduct a preliminary assessment of some health impacts. In UH3 phase, we will focus on the association of these exposures with subsequent outcomes in two focus areas: growth (including insulin resistance and childhood obesity) and respiratory health (including respiratory infections and asthma). We will work completely collaboratively with the ECHO national synthetic cohort to integrate UCP-ELECT into that cohort. We will contribute to the design of the core measures for the synthetic ECHO cohort and implement these within UCP-ELECT. Taken together, this proposal focuses throughout both UG3 and UH3 on novel assessments for exposures that can be translated to other settings of the ECHO synthetic cohort in a feasible and cost-effective manner. We are focused particularly on assessments that can be applied retrospectively in other cohorts to assess very early exposures (peri-conception and early pregnancy). Thus, we will contribute to the ECHO cohort 1) a population-based, pediatric cohort (950 children from 500 families) with extant and new early biospecimens and assessments, and 2) scientific validation of critical multidimensional exposome measurements from preconception through gestation and early childhood. These methods will then be available to assess children across the entire ECHO synthetic cohort to obtain a window on exposures prior to and during gestation, and to assess their impact on the incidence of asthma, obesity, and other outcomes.

项目摘要/摘要（家长资助） 受精、着床和怀孕期间关键发育窗口的早期暴露 可以对儿童的健康、发育和疾病产生长期影响的综合评估。 早期暴露需要对暴露组进行多维评估，包括社区层面 环境因素（包括空气污染）、化学物质暴露（包括内分泌干扰物）、 微生物组（包括共生体和具有相关免疫反应的感染因子），以及 基因组及其对环境的反应（包括遗传的表观基因组、基因组表达和 我们目前正在从围产期入组的两个出生队列中重新入组一个儿科队列。 概念/产前，1) 犹他州国家儿童研究参与者，以及 2) 参与者 家庭围孕期暴露观察 (HOPE) 研究，了解早期生命暴露和儿童 我们还招募了亲生父母和最多一名亲生兄弟姐妹。 UG3阶段（前两年），我们专注于完成整个队列的重新注册，并且还关注 在关键的早期阶段评估一系列已知和新出现的风险的创新方法 我们评估的围孕期和妊娠早期的暴露时间包括微生物组、 药物、感染、泛病毒抗体评估、空气污染物（尤其是颗粒物污染（PM2.5）、 还有氮氧化物和臭氧）、内分泌干扰化学物质（特别是双酚 A (BPA) 和 邻苯二甲酸盐）和牙釉质矿化不足作为早期内分泌干扰暴露的标志。 还将对一些健康影响进行初步评估。在UH3阶段，我们将重点关注以下方面。 这些暴露与以下两个重点领域的后续结果的关联：生长（包括胰岛素 抵抗力和儿童肥胖）和呼吸系统健康（包括呼吸道感染和哮喘）。 与 ECHO 国家综合队列完全合作，将 UCP-ELECT 整合到其中 我们将为合成 ECHO 队列的核心措施的设计做出贡献并实施。 总的来说，该提案在 UG3 和 UH3 中都重点关注小说。 对暴露的评估可以在可行的情况下转化为 ECHO 合成队列的其他设置 我们特别关注可追溯应用的评估。 其他队列来评估非常早期的暴露（围孕期和怀孕早期）因此，我们将做出贡献。 ECHO 队列 1) 一个基于人群的儿科队列（来自 500 个家庭的 950 名儿童）， 新的早期生物样本和评估，以及 2) 关键多维暴露组的科学验证 然后，这些方法将用于从怀孕前到妊娠期和幼儿期的测量。 可用于评估整个 ECHO 合成队列中的儿童，以获得在之前的暴露窗口 以及妊娠期间，并评估它们对哮喘、肥胖和其他结果发生率的影响。