Administrative Core

行政核心

• 批准号: 10176342
• 负责人: Victor Henderson
• 金额: $ 77.42万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10176342
• 关键词: Adopted; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Biological; Brain; Caregivers; Caring; Clinical; Cognition; Collaborations; Communities; Data; Data Storage and Retrieval; Dementia; Dementia with Lewy Bodies; Development; Diagnosis; Early Diagnosis; Ensure; Evaluation; Genetic; Goals; Guidelines; Health Professional; Hispanics; Impaired cognition; Individual; Infrastructure; Institutional Review Boards; Interdisciplinary Study; Leadership; Lewy Bodies; Lewy body pathology; Lewy neurites; Link; Microscopic; Minority Groups; Mission; Monitor; National Institute on Aging; Nerve Degeneration; Neurofibrillary Tangles; Parkinson Disease; Parkinson' s Dementia; Participant; Pathologic; Pathology; Phenotype; Policies; Procedures; Process; Reporting; Research; Research Personnel; Research Training; Resource Sharing; Resources; Risk; Site; Specimen; Structure; Time; United States National Institutes of Health; Universities; Update; age related; aging brain; alpha synuclein; data exchange; disparity reduction; ethnic minority population; high risk; improved; innovation; mild cognitive impairment; next generation; pre-clinical; prevent; racial minority; ranpirnase; repository

1. SUMMARY (Administrative Core) The Stanford Alzheimer's Disease Research Center (ADRC) will support goals of the National Alzheimer's Project Act by serving as a shared resource to facilitate and enhance interdisciplinary and multidisciplinary research on Alzheimer's disease and Alzheimer's disease related dementia (AD/ADRD). At the Stanford ADRC, the focus will be on AD and a common ADRD, namely cognitive impairment and dementia linked to Lewy bodies, Lewy neurites, and the abnormal accumulation and propagation of alpha-synuclein (the Lewy body spectrum of neurodegenerative cognitive impairment). The Stanford ADRC has adopted a strategy of deep phenotyping, which draws together multiple levels of biological data on individual participants followed over time and culminating in brain donation. The Administrative Core provides the administrative structure needed to direct, facilitate and support the Stanford ADRC mission. It establishes the overall scientific direction, provides a forum for planning, ensures optimal resource utilization, and assures compliance with institutional and NIH policy requirements. It will accomplish these goals during the next five years through four specific aims: (1) Provide an infrastructure that establishes priorities and goals of the P30 Stanford ADRC: coordinate activities of ADRC cores and committees; ensure compliance with reporting procedures, policies, and guidelines of the NIH, institutional review board, and other relevant bodies; oversee data transfer to the National Alzheimer's Coordinating Center (NACC) and other entities; and oversee the transfer of biological specimens and genetic data to the National Centralized Repository for Alzheimer's Disease (NCRAD), National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS), and other collaborating groups; (2) Stimulate innovative research on AD/ADRD by existing and new investigators, including the solicitation, evaluation, selection, and monitoring of development projects supported by the Center; (3) Provide leadership opportunities for the next generation of ADRC leaders; and (4) Promote research, training, and educational collaborations with other ADRCs, universities, health professionals, caregiver organizations, and the wider scientific and lay communities.

1。摘要（行政核心） 斯坦福大学阿尔茨海默氏病研究中心（ADRC）将支持国家阿尔茨海默氏症的目标 通过作为共享资源来促进和增强跨学科和多学科的共享资源来行为 关于阿尔茨海默氏病和阿尔茨海默氏病有关的痴呆症（AD/ADRD）的研究。在斯坦福大学 ADRC，重点将放在AD和常见的ADRD上，即认知障碍和痴呆症与痴呆有关 路易尸体，路易神经突，以及α-突触核蛋白的异常积累和传播（Lewy 神经退行性认知障碍的体谱）。斯坦福德ADRC采用了一项策略 深度表型，将各个参与者的生物学数据汇总在一起 随着时间的流逝，并最终是在大脑捐赠中。管理核心提供管理结构 需要指导，促进和支持Stanford ADRC任务。它建立了整体科学 指导，提供一个计划，确保最佳资源利用并确保遵守 机构和NIH政策要求。它将在未来五年内完成这些目标 具体目的：（1）提供了建立P30 Stanford ADRC的优先级和目标的基础设施： 协调ADRC核心和委员会的活动；确保遵守报告程序，政策， NIH，机构审查委员会和其他相关机构的准则；监督数据传输到 国家阿尔茨海默氏症协调中心（NACC）和其他实体；并监督生物学的转移 国家中央集中库的标本和遗传数据，用于阿尔茨海默氏病（NCRAD） 阿尔茨海默氏病数据存储现场（NIAGADS）和其他合作的老化遗传学研究所 群体； （2）刺激现有和新研究人员对AD/ADRD的创新研究，包括 对中心支持的开发项目的征求，评估，选择和监视； （3）提供 下一代ADRC领导者的领导机会； （4）促进研究，培训和 与其他ADRC，大学，卫生专业人员，照顾者组织以及 更广泛的科学和外行社区。