Stanford Alzheimer's Disease Research Center

斯坦福阿尔茨海默病研究中心

• 批准号: 9922029
• 负责人: Victor Henderson
• 金额: $ 301.54万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9922029
• 关键词: Adult; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Artificial Intelligence; Big Data; Bioinformatics; Biological Markers; Biometry; Blood; Brain; Brain imaging; Cell Line; Cells; Clinical; Clinical Management; Cognitive aging; Communities; Consent; Consultations; Data; Data Set; Development; Diagnosis; Disease; Early Diagnosis; Elderly; Family; Feces; Fibroblasts; Foundations; Funding; Future; Goals; Hispanics; Human Resources; Image; Immune; Impaired cognition; Latino; Lewy Bodies; Lewy Body Dementia; Lewy body pathology; Lewy neurites; Link; Liquid substance; Meninges; Mission; Molecular; Nerve Degeneration; Neurodegenerative Disorders; Parkinson Disease; Participant; Pathogenesis; Pathologic; Phenotype; Plasma; Population; Proteomics; Research; Research Personnel; Research Support; Research Training; Resistance; Resource Sharing; Resources; Risk; Skin; Solid; Structure; Therapeutic; Training Support; Training and Education; alpha synuclein; brain tissue; cognitive development; data management; ethnic minority population; high risk; improved; innovation; insight; investigator training; microbiome; motor impairment; multidisciplinary; neuroimaging marker; neuropathology; outreach; pre-clinical; prevent; racial minority; ranpirnase; recruit; repository; resilience; statistics; stool sample; tool; whole genome

1. SUMMARY (Overall) The National Alzheimer's Project Act establishes an integrated national plan to overcome Alzheimer's disease (AD); develop treatments to prevent, halt, or reverse the course of AD; improve the early diagnosis of AD; and decrease disparities in AD for ethnic and racial minority populations at higher risk for AD. In this context, AD is intended to encompass AD-related dementias, including dementia with Lewy bodies. In support of the goals and research milestones of the National Alzheimer's Project Act, the mission of the Stanford Alzheimer's Disease Research Center (ADRC) is to serve as a shared resource to facilitate and enhance research on AD and the spectrum of cognitive impairment associated with Lewy body (LB) pathology. We follow a strategy of deep phenotyping, believing that critical answers emerge more readily when investigators are able to delve deeply within and across multiple levels of participant data. Healthy adults without cognitive or motor impairment serve both as a comparison (control) population and as a preclinical population in which mechanisms of cognitive aging and clinical transition can be studied. People with Parkinson's disease without cognitive impairment also serve as comparators and as an at-risk transitional population for the development of cognitive impairment linked to LB pathology. ADRC resources will provide investigators with unique opportunities for the parallel study of these two neurodegenerative disorders, enabling insights into pathogenesis, preclinical diagnosis, transitions, resistance and resilience, and therapeutic approaches. Aims of the Stanford ADRC are to (1) provide an administrative structure that advances the mission of the center; (2) develop and maintain human resources for studies of the AD spectrum and the LB spectrum of cognitive impairment, as well as cognitive aging; (3) make available well-characterized brain tissues, brain-derived biospecimens, and quantitative molecular data derived from high-content imaging of brain tissues; (4) make available participant biospecimens and high-content biospecimen data; (5) provide structural, functional, and molecular neuroimaging biomarkers in support of research on AD-spectrum cognitive impairment, LB-spectrum cognitive impairment, and cognitive aging; (6) provide for the management of Stanford ADRC data, prepare research datasets, provide high-level biostatistical consultation for ADRC investigators, and support research on big data using tools from biostatistics, bioinformatics, and artificial intelligence; (7) with our community partners, provide respectful, culturally sensitive outreach and provide opportunities for education, training, and research participation for healthy adults, people with AD-spectrum and LB-spectrum disorders, and their families. Stanford ADRC outreach and community engagement extends particularly to urban Hispanic/Latino older adults, an important Bay Area population, which is under-represented in AD-related research; and (8) support the training of investigators and future leaders in the field of AD and related dementia.

1。摘要（总体） 《国家阿尔茨海默氏症计划法》制定了一项综合的国家计划，以克服阿尔茨海默氏病 （广告）;开发治疗方法以防止，停止或扭转AD的过程；改善AD的早期诊断；和 减少AD族裔和种族少数民族的AD差异，其AD风险较高。在这种情况下，广告是 旨在涵盖与广告相关的痴呆症，包括痴呆症和刘易身体。支持目标 以及《国家阿尔茨海默氏症计划法》的研究里程碑，斯坦福·阿尔茨海默氏症的使命 疾病研究中心（ADRC）将作为共享资源，以促进和增强广告的研究 以及与Lewy身体（LB）病理学相关的认知障碍的范围。我们遵循 深度表型，认为当调查人员能够深入研究时，关键答案更容易出现 深入跨越多个参与者数据。没有认知或运动的健康成年人 损害既可以作为比较（对照）人群，也可以作为临床前人口 可以研究认知衰老和临床过渡的机制。患有帕金森氏病的人没有 认知障碍还可以作为比较者和处于危险的过渡人群的发展 与LB病理有关的认知障碍。 ADRC资源将为调查人员提供独特的 对这两种神经退行性疾病的并行研究的机会 发病机理，临床前诊断，过渡，抵抗力和韧性以及治疗方法。目标 斯坦福德ADRC（1）提供了一种行政结构，以推进该中心的任务； （2） 开发和维护人力资源以研究AD频谱和认知的LB频谱 损害以及认知衰老； （3）使特征良好的脑组织，脑部衍生 生物测量和定量分子数据，这些数据来自脑组织的高含量成像； （4）制作 可用的参与者生物测量和高素质生物测量数据； （5）提供结构，功能和 分子神经影像学生物标志物，以支持有关广谱认知障碍的研究 认知障碍和认知衰老； （6）提供Stanford ADRC数据的管理，准备 研究数据集，为ADRC研究人员提供高级生物统计学咨询，并支持研究 在大数据上使用生物统计学，生物信息学和人工智能的工具； （7）与我们的社区一起 合作伙伴，提供尊重，文化敏感的外展活动，并为教育，培训提供机会 健康的成年人，患有广谱和LB谱系障碍的人及其研究参与 家庭。 Stanford ADRC宣传和社区参与特别扩展到城市西班牙裔/拉丁裔城市 老年人是一个重要的湾区人口，在与广告有关的研究中的代表性不足； （8） 支持对AD和相关痴呆症领域的研究人员和未来领导者的培训。