7T Neurosurgical Mapping Protocol for Endoscopic Resection of Skull Base Tumors

颅底肿瘤内镜切除的 7T 神经外科标测方案

• 批准号: 10175768
• 负责人: Priti Balchandani
• 金额: $ 16.95万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10175768
• 关键词: 2019-nCoV; Address; Administrative Supplement; Adult Respiratory Distress Syndrome; Age; Anatomy; Blood Vessels; Brain; Brain Injuries; Brain Stem; Brain region; COVID-19; Cancer Patient; China; Clinical; Control Groups; Coronavirus; Databases; Diagnosis; Diffusion; Disease; Encephalopathies; Excision; Fatality rate; Functional Magnetic Resonance Imaging; Functional disorder; Gender; Goals; Headache; Health; Health system; Hemorrhage; Hippocampus (Brain); Image; Image Analysis; Imaging Techniques; Infection; Informatics; Invaded; Light; Link; Lung; MRI Scans; Magnetic Resonance Imaging; Measurement; Measures; Methods; Middle East Respiratory Syndrome Coronavirus; Multimodal Imaging; Nasal cavity; Nausea; Nervous system structure; Neuraxis; Neurologic; Neurologic Effect; Neurologic Symptoms; Neuropsychology; Olfactory Nerve; Outcome; Pathogenicity; Pathology; Pathway Analysis; Patient Selection; Patients; Prospective Studies; Protocols documentation; Radiologic Finding; Recovery; Reporting; Resolution; Respiration; Respiratory Center; Respiratory Signs and Symptoms; Respiratory System; Respiratory distress; Rest; Retrospective Studies; SARS coronavirus; Sample Size; Scanning; Skull Base Neoplasms; Smell Perception; Stroke; Structure; Survivors; Techniques; Testing; Thalamic structure; Time; Travel; United States National Institutes of Health; Vagus nerve structure; Ventilator; Virus; Virus Diseases; Work; brain abnormalities; brain tissue; brain volume; cancer diagnosis; cohort; contrast enhanced; cytokine release syndrome; design; falls; graph theory; improved; insight; interest; magnetic field; malignant neurologic neoplasms; mental state; multimodality; nervous system disorder; neuroimaging; olfactory bulb; patient population; patient subsets; recruit; respiratory; response; targeted imaging; tool; tractography; ventilation

Project Summary Although neurological symptoms are being observed in a high number of COVID-19 patients, a prospective study aimed at scanning recovered COVID-19 patients with advanced multi-modal neuroimaging methods has yet to be performed. There is much to be learned about the persisting effects of the SARS-CoV-2 virus on the central nervous system, and high-resolution magnetic resonance imaging (MRI) is the ideal non-invasive tool to reveal these effects as well as mechanisms of infection. In this work, we will leverage the high resolution and enhanced contrasts offered by multi-modal 7 Tesla (7T) imaging to study the structural, vascular, functional, and connectomic changes in the brain related to the pathophysiology of COVID-19. In particular, we will reveal, in unprecedented detail, brain abnormalities resulting from the SARS-CoV-2 infection as well as shine a brighter light on possible links to loss of respiratory drive due to viral infection through the brain stem. Imaging findings will be correlated to clinical neurological symptoms and neuropsychological measures. Three patient subgroups will be recruited for our prospective study: non-cancer patients with neurological symptoms who did not require a ventilator, cancer patients with neurological symptoms who did not require a ventilator, and patients who had severe respiratory distress and required ventilation. A retrospective study will also be performed on clinical brain MRI scans for a group of COVID-19 patients with neurological symptoms, seen at Mount Sinai Health System, and outcomes of this analysis will aid in patient selection for the 7T study and additional analysis of persisting versus transient neurological effects. Our study falls within the scope of our R01 application on “7T Neurosurgical Mapping Protocol for Endoscopic Resection of Skull Base Tumors” as we are applying similar multimodal 7T imaging techniques to reveal detailed anatomy in the brain and to characterize effects of disease in both studies. We will simply extend the cohort to include COVID-19 recovered patients and further optimize imaging in the brain stem which will be applicable to both studies. Our study aligns with the goals of the Notice of Special Interest announced by the NCI for administrative supplements on COVID-19 as it addresses potential for differential responses among diverse cancer patient populations to SARS-CoV-2 infection or COVID-19 disease in central nervous system.

项目摘要 尽管在大量的Covid-19患者中观察到神经系统症状，但一项前瞻性研究 针对扫描恢复的共同COVID-19患者，具有晚期多模式神经影像学方法的尚未 被执行。关于SARS-COV-2病毒对中央的持续作用有很多了解 神经系统和高分辨率磁共振成像（MRI）是揭示的理想非侵入性工具 这些作用以及感染的机制。在这项工作中，我们将利用高分辨率并增强 多模式7特斯拉（7T）成像提供的对比，以研究结构，血管，功能和 大脑中的连接瘤变化与COVID-19的病理生理学有关。特别是，我们将揭示 在前所未有的细节中，SARS-COV-2感染引起的大脑异常以及更明亮 通过脑干病毒感染引起的呼吸道驱动丧失的可能联系。成像发现 将与临床神经系统症状和神经心理学措施相关。三个患者亚组 将招募我们的前瞻性研究：不需要的神经系统症状的非癌症患者 呼吸机，不需要呼吸机的神经系统症状的癌症患者， 严重的呼吸窘迫和需要通风。回顾性研究也将在临床大脑上进行 在西奈山卫生系统中看到的一组神经系统症状的Covid-19患者的MRI扫描， 该分析的结果将有助于患者选择7T研究，并进行持续存在的其他分析 与瞬态神经系统作用。我们的研究属于“ 7T” R01应用程序的范围 当我们采用相似 多模式7T成像技术以揭示大脑中详细的解剖结构并表征疾病的影响 在两项研究中。我们将仅将队列扩展到包括Covid-19恢复的患者并进一步优化 在脑干中成像，这将适用于两项研究。我们的研究与通知的目标保持一致 NCI宣布的特殊兴趣是在Covid-19的行政补品上宣布的。 潜在的潜在潜在的对SARS-COV-2感染或 中枢神经系统中的Covid-19疾病。

项目成果

Neuroimaging findings and neurological manifestations in hospitalized COVID-19 patients: Impact of cancer and ventilatory support status.

• DOI: 10.1371/journal.pone.0283614
• 发表时间: 2023
• 期刊: PloS one
• 影响因子: 3.7

Ultrahigh field MR Neuroimaging.

超高场磁共振神经成像。

• DOI: 10.1097/rmr.0000000000000210
• 发表时间: 2019
• 期刊: Topics in magnetic resonance imaging : TMRI
• 作者: Verma,Gaurav;Balchandani,Priti
• 通讯作者: Balchandani,Priti

Subfield-specific tractography of the hippocampus in epilepsy patients at 7 Tesla.

• DOI: 10.1016/j.seizure.2018.09.005
• 发表时间: 2018-11
• 期刊: Seizure
• 作者: Rutland JW;Feldman RE;Delman BN;Panov F;Fields MC;Marcuse LV;Hof PR;Lin HM;Balchandani P
• 通讯作者: Balchandani P

Hippocampal subfield-specific connectivity findings in major depressive disorder: A 7 Tesla diffusion MRI study.

重度抑郁症中海马亚区特异性连接的发现：一项 7 特斯拉扩散 MRI 研究。

• DOI: 10.1016/j.jpsychires.2019.02.008
• 发表时间: 2019
• 期刊: Journal of psychiatric research
• 影响因子: 4.8
• 作者: Rutland,JohnW;Brown,Stephanie;Verma,Gaurav;Feldman,RebeccaE;Sharma,Himanshu;Markowitz,Matthew;Schneider,Molly;Delman,BradleyN;Murrough,James;Balchandani,Priti
• 通讯作者: Balchandani,Priti

Improvement of magnetic resonance imaging using a wireless radiofrequency resonator array.

• DOI: 10.1038/s41598-021-02533-3
• 发表时间: 2021-11-29
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Alipour A;Seifert AC;Delman BN;Robson PM;Shrivastava R;Hof PR;Adriany G;Fayad ZA;Balchandani P
• 通讯作者: Balchandani P