Translational Research Activities in Neuropsychiatry (TRAIN) - Renewal - 1

神经精神病学转化研究活动 (TRAIN) - 更新 - 1

• 批准号: 10171037
• 负责人: MADHUKAR H. TRIVEDI
• 金额: $ 21.59万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-10 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10171037
• 关键词: Adaptive Behaviors; Adoption; Area; Biological; Biological Markers; Clinical; Clinical Research; Cognition; Communities; Coupled; Cultural Diversity; Detection; Development; Diagnosis; Disease; Doctor of Philosophy; Electroencephalography; Epigenetic Process; Etiology; Faculty; Foundations; Functional disorder; Funding; Genetic; Genetic Research; Goals; Individual; Infrastructure; Knowledge; Lead; Leadership; Mental Health; Mental disorders; Mentors; National Institute of Mental Health; Neurobiology; Neurosciences; Neurosciences Research; Outcome; Physicians; Population; Precision therapeutics; Prevention; Process; Productivity; Proteomics; Psychiatric therapeutic procedure; Psychiatry; Research; Research Activity; Research Domain Criteria; Research Personnel; Research Project Grants; Research Training; Residencies; Resources; Rural; Science; Scientist; Self Care; Solid; Structure; Target Populations; Techniques; Technology; Time; Training; Training Programs; Translating; Translational Research; Translations; Work; Youth; addiction; base; biomarker evaluation; burnout; career; clinical care; design; improved; innovation; leadership development; medical schools; neuroimaging; neuropsychiatry; next generation; novel; optimism; personalized medicine; precision medicine; prevent; programs; prospective; resilience; skill acquisition; skills; tool; translational scientist; treatment optimization; treatment response

PROJECT SUMMARY Rapid developments in neuroscientific approaches, technologies, and analytics to understand the pathophysiology and treatment of mental illnesses have resulted in major advances that serve as a strong base toward the translation of cutting-edge research into personalized treatments for psychiatric conditions. In order to best leverage these advances, it is imperative that the next generation of researchers in psychiatry receive focused training that integrates translational research with clinical training. Psychiatric training programs that provide this focus, in conjunction with dedicated research time, and leadership and related skill development, are greatly needed. While there is concern in the field of a profound shortage of physician- scientists being trained, there is also reason for optimism, in that the number of MD/PhD medical school graduates applying for psychiatric residencies has increased. Our clinical and translational research training program, Translational Research Activities In Neuropsychiatry (TRAIN) is designed to provide exceptional training and mentoring to psychiatry residents with the express goal of generating clinical and translational researchers in psychiatry who will go on to become independent physician-scientists. This program focuses on the relationship between disruptions in underlying genetics and neurobiology and how they relate to adaptive behavior, as in the NIMH Research Domain Criteria (RDoC) framework, as well as the emergence of biomarkers that can inform clinical care. The TRAIN program harnesses the expertise and processes our faculty employ to bridge existing gaps in the field. This includes focused work and expertise in critical content areas, populations, and settings, as well as the use of approaches that span all ranges of translational science from the bench to the community. Our structured program provides an exceptional mentoring plan with experiential opportunities to participating residents coupled with timely didactics. The TRAIN program is specifically designed to train the next generation of researchers so that they can translate neuroscience and genetics research into advancements of our understanding of a wide range of mental health problems and treatments. TRAIN facilitates team science mentoring and training that is needed for translational research, with an emphasis on productivity through the conduct of a mentored research project, as well as deliverables such as networking and development of funding proposals to equip trainees for their next steps in training and academic research. TRAIN also focuses on wellness and guarding against burnout to encourage early adoption of self-care and enhance resilience.

项目摘要 神经科学方法，技术和分析的快速发展，以了解 病理生理学和精神疾病的治疗导致了重大进展，这是一个强大的 基于将尖端研究转化为精神病疾病的个性化治疗方法的基础。在 为了最好地利用这些进步，必须在精神病学领域的下一代研究人员 接受重点培训，将转化研究与临床培训相结合。精神病训练 与专门的研究时间以及领导和相关技能一起提供这种重点的计划 开发非常需要。虽然在严重短缺医师的领域担心 - 受过培训的科学家也有乐观的理由，因为MD/PHD医学院的数量 申请精神科住院医师的毕业生有所增加。我们的临床和转化研究培训 计划，神经精神病学的转化研究活动（火车）旨在提供卓越 对精神病学居民进行培训和指导，其明确的目标是产生临床和翻译 精神病学研究人员将继续成为独立的医师科学家。该计划重点 潜在遗传学和神经生物学的中断及其与适应性的关系之间的关系 行为，如NIMH研究领域标准（RDOC）框架，以及出现 可以为临床护理提供信息的生物标志物。火车计划利用专业知识并处理我们的 教师雇用弥合现有差距。这包括关注工作和关键内容方面的专业知识 领域，人口和设置，以及跨越转化科学范围的方法的使用 从板凳到社区。我们的结构化计划提供了一个杰出的指导计划 参加居民的体验机会以及及时的教学法。火车计划是 专门设计用于培训下一代研究人员，以便他们可以翻译神经科学和 遗传学研究我们对广泛心理健康问题的理解的进步和 治疗。火车促进转化研究所需的团队科学指导和培训， 通过进行指导的研究项目和可交付成果来强调生产力 例如网络和发展资金建议，以使学员为他们的下一步培训和 学术研究。火车还专注于健康和防止倦怠以鼓励早期 采用自我保健并增强弹性。