Mechanisms underlying sensory over-responsivity in ASD and early adversity

自闭症谱系障碍和早期逆境中感觉过度反应的潜在机制

基本信息

批准号：
9977797
负责人：
Shulamite Abra Green
金额：
$ 19.28万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9977797
关键词：
Adaptive Behaviors Adopted Adoption Affect Age Amygdaloid structure Anxiety Area Arousal Attention Attention deficit hyperactivity disorder Award Behavioral Brain Brain imaging California Child Childhood Clinic Clinical Clothing Cues Development Dimensions Doctor of Philosophy Emotional Emotions Environment Environmental Risk Factor Exposure to Face Processing Family Fetal Alcohol Exposure Foundations Frequencies Functional Imaging Functional Magnetic Resonance Imaging Future Galvanic Skin Response Genetic Genetic Risk Goals Grant Heart Rate Hyperactive behavior Impairment Individual Individual Differences Intervention Link Los Angeles Loudness Measures Mental Health Mental disorders Mentorship Methods National Institute of Mental Health Neural Pathways Neurobiology Neurodevelopmental Disorder Noise Participant Pathway interactions Pattern Phenotype Physiological Population Population Heterogeneity Postdoctoral Fellow Process Psychophysiology Reaction Time Research Research Domain Criteria Research Personnel Risk Risk Factors Sensory Severities Social Behavior Social Functioning Source Stimulus Strategic Planning Testing Touch sensation Training Translational Research Universities Work Youth auditory stimulus autism spectrum disorder autistic children base brain behavior brain circuitry brain pathway career career development comparative coping early life adversity early life stress foster care habituation high risk high risk population neglect neural patterning neurobiological mechanism neuroimaging preservation professor relating to nervous system research and development resilience sensory cortex sensory mechanism sensory stimulus social social deficits social skills tool

项目摘要

Candidate: This is a K08 application for Shulamite Green, Ph.D., an F32 postdoctoral fellow at the University of California Los Angeles (transitioning to assistant professor by the award start date). Dr. Green's career goal is to become an independent investigator and leader in the field of sensory over-responsivity (SOR) from an interdisciplinary and transdiagnostic perspective. This K08 award will provide Dr. Green with the necessary training to gain expertise in 1) behavioral and psychophysiological methods of assessing SOR; 2) advanced brain connectivity methods; and 3) the effect of early life stress on the development of brain, behavior, and risk for psychiatric disorders. Environment: Mentorship will be provided by Drs. Susan Bookheimer, Michelle Craske, and Nim Tottenham, experts in cutting-edge neuroimaging methods, psychophysiology and translational research, and the effect of early life stress on the brain, respectively. Research and Career Development: Sensory over-responsivity (SOR) is an impairing condition manifested as extreme sensitivity to stimuli such as being touched, scratchy clothing, or loud noises. SOR is pervasive across neurodevelopmental disorders with both genetic and environmental causes, including over 50% of children with autism spectrum disorders (ASD) and those with early life stress. However, little is known about the underlying mechanisms for risk and resilience to SOR across populations, and SOR is not well identified or treated in most clinical groups. The proposed study will integrate behavioral, psychophysiological, and neuroimaging methods to characterize SOR across youth with ASD and those with early life stress. Participants will be 28 children with early life stress due to adoption from foster care (AFC), 28 with ASD and 28 age- and IQ-matched typically developing (TD) controls, ages 8-16 years. The aims of the study include: 1) examining shared and distinct behavioral and pyschophysiological markers of SOR as well as their relation to mental health difficulties and social competence; 2) using functional imaging (fMRI) to test whether SOR is related to similar patterns of neural responsiveness, habituation, and functional connectivity during sensory stimulation in AFC, ASD, and TD youth; and 3) examining group differences in the effect of distracting auditory stimuli on reaction time, physiological arousal, and functional brain connectivity during emotion identification. This work will contribute to the field by facilitating an interdisciplinary understanding of SOR as a transdiagnostic phenotype with implications for improvement of targeted assessment and intervention. These aims are consistent with the Research Domain Criteria (RDoC) framework as well as the NIMH strategic plan to focus on individual differences in brain circuitry across diverse populations as a source of risk and resilience for mental illness. This research will lay the foundation for Dr. Green's career as a leading expert in the neurobiology of SOR. Results will support a future R01 grant focused on common and distinct neural pathways of SOR across populations, as well as the refinement of SOR identification and treatment tools to target specific populations.

候选人：这是 Shulamite Green 博士的 K08 申请，他是该大学的 F32 博士后研究员加利福尼亚州洛杉矶（在奖励开始日期之前过渡为助理教授）。格林博士的职业目标目标是从一名儿童成为感觉过度反应（SOR）领域的独立研究者和领导者跨学科和跨诊断的视角。这个 K08 奖项将为格林博士提供必要的培训以获得以下方面的专业知识：1) 评估 SOR 的行为和心理生理学方法； 2）高级大脑连接方法； 3) 早期生活压力对大脑发育、行为和风险的影响对于精神疾病。环境：指导将由博士提供。苏珊·布克海默，米歇尔 Craske 和 Nim Tottenham 是尖端神经影像学方法、心理生理学和转化研究，以及早期生活压力对大脑的影响。研究与职业发展：感觉过度反应（SOR）是一种损害状况，表现为对刺激，例如触摸、刮擦的衣服或大声的噪音。 SOR 在神经发育过程中普遍存在遗传和环境原因造成的疾病，其中超过 50% 的儿童患有自闭症谱系障碍（自闭症谱系障碍）和那些有早期生活压力的人。然而，人们对其背后的机制知之甚少。不同人群的 SOR 风险和恢复能力不同，并且在大多数临床群体中，SOR 尚未得到很好的识别或治疗。拟议的研究将整合行为、心理生理学和神经影像学方法来表征患有自闭症谱系障碍 (ASD) 和早期生活压力的青少年的 SOR。参与者将是 28 名早年儿童 28 名患有自闭症谱系障碍 (ASD) 和 28 名年龄和智商匹配的儿童通常会因寄养 (AFC) 收养而承受压力 (TD) 对照，年龄 8-16 岁。研究的目的包括：1）检查共同的和独特的行为和 SOR 的心理生理标志及其与心理健康困难和社交的关系权限; 2）使用功能成像（fMRI）来测试SOR是否与类似的神经模式有关 AFC、ASD 和 TD 感觉刺激期间的反应性、习惯性和功能连接青年; 3）检查分散注意力的听觉刺激对反应时间影响的组间差异，情绪识别过程中的生理唤醒和功能性大脑连接。这项工作将有助于通过促进对 SOR 作为跨诊断表型的跨学科理解对改进有针对性的评估和干预的影响。这些目标与研究领域标准 (RDoC) 框架以及 NIMH 战略计划重点关注个人不同人群的大脑回路差异是精神疾病风险和恢复力的来源。这项研究将为 Green 博士作为 SOR 神经生物学领先专家的职业生涯奠定基础。结果将支持未来的 R01 资助，重点关注 SOR 的常见和独特神经通路人群，以及针对特定人群改进 SOR 识别和治疗工具。