Mechanisms underlying sensory over-responsivity in ASD and early adversity

自闭症谱系障碍和早期逆境中感觉过度反应的潜在机制

基本信息

批准号：
9977797
负责人：
Shulamite Abra Green
金额：
$ 19.28万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9977797
关键词：
Adaptive Behaviors Adopted Adoption Affect Age Amygdaloid structure Anxiety Area Arousal Attention Attention deficit hyperactivity disorder Award Behavioral Brain Brain imaging California Child Childhood Clinic Clinical Clothing Cues Development Dimensions Doctor of Philosophy Emotional Emotions Environment Environmental Risk Factor Exposure to Face Processing Family Fetal Alcohol Exposure Foundations Frequencies Functional Imaging Functional Magnetic Resonance Imaging Future Galvanic Skin Response Genetic Genetic Risk Goals Grant Heart Rate Hyperactive behavior Impairment Individual Individual Differences Intervention Link Los Angeles Loudness Measures Mental Health Mental disorders Mentorship Methods National Institute of Mental Health Neural Pathways Neurobiology Neurodevelopmental Disorder Noise Participant Pathway interactions Pattern Phenotype Physiological Population Population Heterogeneity Postdoctoral Fellow Process Psychophysiology Reaction Time Research Research Domain Criteria Research Personnel Risk Risk Factors Sensory Severities Social Behavior Social Functioning Source Stimulus Strategic Planning Testing Touch sensation Training Translational Research Universities Work Youth auditory stimulus autism spectrum disorder autistic children base brain behavior brain circuitry brain pathway career career development comparative coping early life adversity early life stress foster care habituation high risk high risk population neglect neural patterning neurobiological mechanism neuroimaging preservation professor relating to nervous system research and development resilience sensory cortex sensory mechanism sensory stimulus social social deficits social skills tool

Adaptive Behaviors Adopted Adoption Affect Age Amygdaloid structure Anxiety Area Arousal Attention Attention deficit hyperactivity disorder Award Behavioral Brain Brain imaging California Child Childhood Clinic Clinical Clothing Cues Development Dimensions Doctor of Philosophy Emotional Emotions Environment Environmental Risk Factor Exposure to Face Processing Family Fetal Alcohol Exposure Foundations Frequencies Functional Imaging Functional Magnetic Resonance Imaging Future Galvanic Skin Response Genetic Genetic Risk Goals Grant Heart Rate Hyperactive behavior Impairment Individual Individual Differences Intervention Link Los Angeles Loudness Measures Mental Health Mental disorders Mentorship Methods National Institute of Mental Health Neural Pathways Neurobiology Neurodevelopmental Disorder Noise Participant Pathway interactions Pattern Phenotype Physiological Population Population Heterogeneity Postdoctoral Fellow Process Psychophysiology Reaction Time Research Research Domain Criteria Research Personnel Risk Risk Factors Sensory Severities Social Behavior Social Functioning Source Stimulus Strategic Planning Testing Touch sensation Training Translational Research Universities Work Youth auditory stimulus autism spectrum disorder autistic children base brain behavior brain circuitry brain pathway career career development comparative coping early life adversity early life stress foster care habituation high risk high risk population neglect neural patterning neurobiological mechanism neuroimaging preservation professor relating to nervous system research and development resilience sensory cortex sensory mechanism sensory stimulus social social deficits social skills tool

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项目摘要

Candidate: This is a K08 application for Shulamite Green, Ph.D., an F32 postdoctoral fellow at the University of California Los Angeles (transitioning to assistant professor by the award start date). Dr. Green's career goal is to become an independent investigator and leader in the field of sensory over-responsivity (SOR) from an interdisciplinary and transdiagnostic perspective. This K08 award will provide Dr. Green with the necessary training to gain expertise in 1) behavioral and psychophysiological methods of assessing SOR; 2) advanced brain connectivity methods; and 3) the effect of early life stress on the development of brain, behavior, and risk for psychiatric disorders. Environment: Mentorship will be provided by Drs. Susan Bookheimer, Michelle Craske, and Nim Tottenham, experts in cutting-edge neuroimaging methods, psychophysiology and translational research, and the effect of early life stress on the brain, respectively. Research and Career Development: Sensory over-responsivity (SOR) is an impairing condition manifested as extreme sensitivity to stimuli such as being touched, scratchy clothing, or loud noises. SOR is pervasive across neurodevelopmental disorders with both genetic and environmental causes, including over 50% of children with autism spectrum disorders (ASD) and those with early life stress. However, little is known about the underlying mechanisms for risk and resilience to SOR across populations, and SOR is not well identified or treated in most clinical groups. The proposed study will integrate behavioral, psychophysiological, and neuroimaging methods to characterize SOR across youth with ASD and those with early life stress. Participants will be 28 children with early life stress due to adoption from foster care (AFC), 28 with ASD and 28 age- and IQ-matched typically developing (TD) controls, ages 8-16 years. The aims of the study include: 1) examining shared and distinct behavioral and pyschophysiological markers of SOR as well as their relation to mental health difficulties and social competence; 2) using functional imaging (fMRI) to test whether SOR is related to similar patterns of neural responsiveness, habituation, and functional connectivity during sensory stimulation in AFC, ASD, and TD youth; and 3) examining group differences in the effect of distracting auditory stimuli on reaction time, physiological arousal, and functional brain connectivity during emotion identification. This work will contribute to the field by facilitating an interdisciplinary understanding of SOR as a transdiagnostic phenotype with implications for improvement of targeted assessment and intervention. These aims are consistent with the Research Domain Criteria (RDoC) framework as well as the NIMH strategic plan to focus on individual differences in brain circuitry across diverse populations as a source of risk and resilience for mental illness. This research will lay the foundation for Dr. Green's career as a leading expert in the neurobiology of SOR. Results will support a future R01 grant focused on common and distinct neural pathways of SOR across populations, as well as the refinement of SOR identification and treatment tools to target specific populations.

候选人：这是Shulamite Green博士的K08申请，该大学是大学的F32博士后研究员加利福尼亚洛杉矶（通过奖励开始日期过渡到助理教授）。格林博士的职业目标是成为感官过度反应性（SOR）领域的独立研究者和领导者跨学科和转诊的观点。该K08奖将为格林博士提供必要的培训以获得1）评估SOR的行为和心理生理学方法； 2）高级大脑连接方法； 3）早期生活压力对大脑，行为和风险发展的影响用于精神疾病。环境：指导将由博士提供。 Susan Bookheimer，Michelle Craske和Nim Tottenham，尖端神经影像学方法，心理生理学和转化研究和早期生活压力分别对大脑的影响。研究和职业发展：感官过度反应性（SOR）是一种表现为对刺激，例如被触摸，刮擦的衣服或大声的噪音。 SOR在神经发育中无处不在患有遗传和环境原因的疾病，包括超过50％的自闭症儿童疾病（ASD）和患有早期压力的人。但是，关于的基本机制知之甚少在大多数临床组中，对跨种群的SOR和SOR的风险和韧性都没有得到很好的识别或治疗。拟议的研究将整合行为，心理生理和神经影像学方法以表征跨越ASD的年轻人和患有早期压力的年轻人。参与者将是28个有早年生活的孩子由于寄养护理（AFC）的采用，28岁的ASD和28岁和IQ匹配的压力通常会发展（TD）对照，8-16岁。该研究的目的包括：1）检查共享和独特的行为和 SOR的杂质生理标记及其与心理健康困难和社会的关系权限; 2）使用功能成像（fMRI）测试SOR是否与神经的类似模式有关在AFC，ASD和TD中感觉刺激期间的响应能力，习惯和功能连接性青年; 3）检查分散听觉刺激对反应时间的影响的群体差异，情绪识别期间的生理唤醒和功能性大脑连通性。这项工作将有助于通过促进对SOR的跨学科理解，该领域是一种经诊断表型对改善目标评估和干预的影响。这些目标与研究领域标准（RDOC）框架以及NIMH的战略计划，专注于个人不同种群的脑电路的差异是对精神疾病的风险和韧性的来源。这项研究将为格林博士作为SOR神经生物学领先专家的职业奠定基础。结果将支持未来的R01赠款，该赠款专注于跨越常见和独特的神经途径种群，以及SOR识别和治疗工具的改进，以针对特定人群。