Botanical Dietary Supplements

植物膳食补充剂

• 批准号: 10169164
• 负责人: BRIAN BURBACK
• 金额: $ 38.6万
• 依托单位: BATTELLE CENTERS/PUB HLTH RES & EVALUATN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-25 至 2020-05-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10169164
• 关键词: Adverse effects; Angelica sinensis preparation; Animals; Biological; Botanical dietary supplements; Chemicals; Chemistry; Cimicifuga racemosa; Complex; Contracts; Development; Dose; Echinacea purpurea; Ensure; Evaluation; Exposure to; Formulation; Garcinia; Goals; Human Cell Line; Link; National Toxicology Program; Outcome; Preparation; Public Health; Research; Risk Assessment; Sampling; Specific qualifier value; Testing; Toxic effect; Toxicity Tests; in vitro testing; programs; sound

The goal of this project is to provide support of National Toxicology Program (NTP) researching the potential adverse effect of botanical dietary supplements. Botanical dietary supplement research has several challenges including identifying the active ingredients to link them to observed outcomes due to complex makeup of the mixtures. Proper chemical analyses are required to ensure that, in toxicity studies, the test species are exposed to the test articles at the specified dose concentrations. This contract characterizes the chemical and physical composition of the botanical dietary supplements studied in the testing program. This information is critical to evaluation of toxicity tests and development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species and ultimately supports the risk assessment efforts of the National Toxicology Program and other federal agencies. In addition, this contract also provides chemistry support for in vitro testing in multiple animal and human cell lines of a wide variety of chemicals of public health concern.

该项目的目的是提供支持国家毒理学计划（NTP）的支持，以研究植物饮食补充剂的潜在不利影响。植物饮食补充剂研究面临着几个挑战，包括确定由于混合物的复杂构成，将它们与观察到的结果联系起来。 需要进行适当的化学分析，以确保在毒性研究中，测试物种以指定的剂量浓度暴露于测试文章中。该合同表征了在测试计划中研究的植物饮食补充剂的化学和物理组成。该信息对于评估毒性测试和声音的发展至关重要，关于研究物种中研究化学物质的潜在毒性的科学结论，最终支持国家毒理学计划和其他联邦机构的风险评估工作。此外，该合同还为多种公共卫生关注的多种化学物质的多种动物和人类细胞系中的体外测试提供了化学支持。