Polycyclic Aromatic Compound Mixture Assessment Program (PAC-MAP)

多环芳香族化合物混合物评估计划（PAC-MAP）

• 批准号: 10413778
• 负责人: BRIAN BURBACK
• 金额: $ 15.12万
• 依托单位: BATTELLE CENTERS/PUB HLTH RES & EVALUATN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-25 至 2022-05-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10413778
• 关键词: Adverse effects; Animals; Anthracenes; Aromatic Compounds; Benzo(a)pyrene; Chemicals; Chemistry; Chrysenes; Complex Mixtures; Contracts; Crude Extracts; Development; Dose; Ensure; Environmental Exposure; Evaluation; Exposure to; Fluorenes; Goals; Hazard Identification; Hazardous Chemicals; Health; Heightened Cancer Risk; Human; Human Cell Line; National Toxicology Program; Outcome; Preparation; Public Health; Pyrenes; Reporting; Risk Assessment; Risk Factors; Sampling; Ships; Specific qualifier value; Testing; Toxic effect; Toxicity Tests; Toxicology; disorder prevention; dose information; fluoranthene; in vitro testing; programs; public health research; screening; sound; wood smoke

The goal of this project is to provide support of National Toxicology Program (NTP) hazard identification activities targeted towards the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper chemical analyses are required to ensure that, in toxicity studies, the test species are exposed to the prescribed chemicals at the specified dose concentrations. This contract contributes to the ability of toxicity studies to provide evidence of heightened cancer risk along with other toxicological outcomes, by providing characterization of the chemicals studied, confirmation of the dose levels administered, and internal dose determinations. This information is critical to evaluation of toxicity tests and development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. With internal dose information provided by this contract, extrapolations to humans can be made so that the public can be adequately informed about risk factors arising from exposure to studied chemicals. In addition, this contract also provides chemistry support for in vitro testing in multiple animal and human cell lines of a wide variety of chemicals of public health concern.

该项目的目的是提供国家毒理学计划（NTP）危害识别活动的支持，该危害识别活动针对预防疾病或由环境暴露于化学或物理剂引起的不良影响。毒性测试是公共卫生研究的重要方面，它有助于识别对人类健康有害的化学物质。需要进行适当的化学分析，以确保在毒性研究中，测试物种以指定的剂量浓度暴露于规定的化学物质。该合同有助于毒性研究能够通过提供所研究的化学物质的表征，确认给予的剂量水平和内部剂量确定来提供癌症风险增加以及其他毒理学结果的证据。该信息对于评估毒性测试和声音的发展至关重要，有关研究化学物质中潜在毒性的科学结论，最终支持国家毒理学计划和其他联邦机构的风险评估工作。有了本合同提供的内部剂量信息，可以对人类进行外推，以便可以充分了解公众对研究化学物质的风险因素。此外，该合同还为多种公共卫生关注的多种化学物质的多种动物和人类细胞系中的体外测试提供了化学支持。