Serotonergic Botanicals for Menopausal Treatment

用于更年期治疗的血清素植物药

基本信息

批准号：
7523931
负责人：
Sharla Latrice White
金额：
$ 4.1万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-12-01 至 2009-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7523931
关键词：
5HT5A receptor Address Adverse effects Affect Affinity Age Alternative Medicine Alternative Therapies Angelica sinensis Angelica sinensis preparation Animal Model Animals Antidepressive Agents Area Binding Biological Biological Assay Biological Availability Biological Testing Black Cohosh Extract Botanicals Breast Cancer Etiology Case Study Cell Culture Techniques Cell Line Cells Chemicals Cimicifuga Cimicifuga racemosa Circadian Rhythms Clinical Trials Collaborations Competitive Binding Crude Extracts Cyclic AMP Data Development Dose Endometrial Endometrial Carcinoma Enzyme Kinetics Estrogen Replacement Therapy Estrogens Evaluation Exhibits Fractionation Fright Future Goals Health Benefit Health Personnel High Pressure Liquid Chromatography Hormone replacement therapy Hormones Hot flushes Human Resources In Vitro Incidence Injury Laboratories Lead Life Life Expectancy Literature Liver Maintenance Mammary Gland Parenchyma Menopausal Symptom Menopause Methodology Methods Mind Moods Natural Remedy Pathway interactions Perception Perimenopause Pharmaceutical Preparations Phase Phase I Clinical Trials Physiologic Thermoregulation Plant Extracts Plants Postmenopause Premenstrual syndrome Problem Solving Process Progestins Publishing Quality of life Reporting Research Resistance Risk Safety Serotonin Sleep Sleep Deprivation Sleep disturbances Sleeplessness Staging Standardization Surveys Sweat Sweating Swimming Symptoms Testing Time Toxic effect Training Activity Valerian Woman Women&apos s Health Work base cancer risk career combat depression dietary supplements estrogenic activity experience falls hormone therapy improved in vitro Assay in vivo interest malignant breast neoplasm men metabolic abnormality assessment peace receptor safety study serotonin 7 receptor serotonin receptor serotonin transporter skills standard care uptake

项目摘要

DESCRIPTION (provided by applicant): Menopausal women suffer a wide range of symptoms, such as hot flashes, sleep disturbance, insomnia, depression and mood changes, a result of reduced levels of estrogenic hormones in the body. These symptoms lead to a negative effect on their quality of life. Hormone replacement therapy (HRT) was originally developed as a means to combat these effects; however, recent studies have shown that HRT can cause increased endometrial and breast cancer risks thereby motivating women to refuse treatment or seek alternative avenues of treatment. As a result, in recent years, a growing interest in botanical dietary supplements has occurred; however, in most cases the efficacy of these supplements lack scientific evidence thus resulting in a necessity to provide substantial and high quality research for these natural remedies. Cimicifuga racemosa (Black Cohosh), Angelica sinensis (Dong Quai), and Valerian officinalis (Valerian) have all proven effective botanical treatments for the relief of hot flashes and as a sleeping aid, respectively, in clinical trials. Ms. Powell's main goal will be to investigate a variety of plant extracts and active compounds to evaluate their serotonergic activity .The training will continue providing the applicant with opportunity to build stronger problem-solving and technical skills utilizing scientific methodology. This research will incur in vitro methods of cell culture and enzyme kinetics as well as in vivo animal models. This will also serve to prepare Ms. Powell for her future career in research focused on botanical and dietary supplements and add to the scientific literature on the topic. The core hypothesis of this study is to examine plant extracts that have not only shown serotonergic activity, but also plant extracts with potential serotonergic activity for the relief of menopausal symptoms without leading to detrimental side effects such as breast or endometrial cancer. The specific aims are to evaluate the serotonergic activity of plant extracts in vitro, as it relates to maintenance of thermoregulation, mood, and circadian rhythm. Evaluation and determination of antidepressant activity of plant extracts in vitro, followed by bioassay guided fractionation to isolate active components of the botanical dietary supplements. In short, advancements in natural plant remedies can prove a valuable alternative form of treatment for menopausal and postmenopausal women who are concerned about the side effects caused by hormone replacement therapy. The discovery of an effective botanical extract that relieves any menopausal symptoms will potentially improve quality of life and peace of mind for all affected women.

描述（由申请人提供）：绝经女性患有广泛的症状，例如炎热，睡眠障碍，失眠，抑郁和情绪变化，这是体内雌激素水平降低的结果。这些症状会对其生活质量产生负面影响。激素替代疗法（HRT）最初是为了对抗这些影响的一种手段。但是，最近的研究表明，HRT可能导致子宫内膜和乳腺癌的风险增加，从而激发妇女拒绝治疗或寻求替代治疗途径。结果，近年来，对植物饮食补充剂的兴趣日益增加。但是，在大多数情况下，这些补充剂的功效缺乏科学证据，因此有必要为这些自然疗法提供大量和高质量的研究。 Cimicifuga racemosa（黑色cohosh），当归Sinensis（Dong Quai）和Valerian officinalis（Valerian）都在临床试验中证明了有效的植物治疗方法，分别用于缓解炎热闪光灯和睡眠辅助。鲍威尔女士的主要目标是研究各种植物提取物和活性化合物，以评估其血清素能活动。该培训将继续为申请人提供利用科学方法的更强大的解决问题和技术技能的机会。这项研究将引起细胞培养和酶动力学以及体内动物模型的体外方法。这还将为鲍威尔女士做好准备，以使其未来的研究专注于植物和饮食补充剂，并增加了有关该主题的科学文献。这项研究的核心假设是检查植物提取物不仅显示出血清素能活性，而且还检查具有潜在的血清素能活性的植物提取物，可缓解绝经症状，而不会导致乳腺癌或子宫内膜癌等有害副作用。具体目的是评估体外植物提取物的血清素能活性，因为它与温度调节，情绪和昼夜节律有关。评估和测定植物提取物在体外的抗抑郁活性，然后进行生物测定指导分馏，以分离植物饮食补充剂的活性成分。简而言之，自然植物疗法的进步可以证明一种对绝经和绝经后妇女的宝贵替代形式，这些治疗对激素替代疗法引起的副作用感到关注。发现有效的植物提取物可以缓解任何更年期症状，这可能会改善所有受影响妇女的生活质量和安心。