The Symptom Experience, Management and Outcomes According to Race and Social Determinants of Health (SEMOARS) during Breast Cancer Chemotherapy

乳腺癌化疗期间根据种族和健康社会决定因素 (SEMOARS) 的症状体验、管理和结果

• 批准号: 10162315
• 负责人: Margaret Q. Rosenzweig
• 金额: $ 59.93万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-27 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10162315
• 关键词: Adherence; Age; Area; Audiotape; Breast Cancer Treatment; Caring; Chemotherapy-Oncologic Procedure; Clinic Visits; Clinical; Clinical Trials; Code; Communication; Communities; Data Collection; Disease; Disease Progression; Distress; Dose; Drops; Early treatment; Education; Elements; Empathy; Ensure; Financial Hardship; Foundations; Goals; Health; Incidence; Income; Infrastructure; Institutes; Insurance Coverage; Intervention; Intervention Trial; Investments; Literature; Malignant Neoplasms; Measures; Mediating; Medical; Methods; Modeling; Ohio; Outcome; Parents; Participant; Patients; Pennsylvania; Perception; Population; Process; Provider; Public Health; Quality of Care; Quality of life; Race; Regimen; Reporting; Research; Research Project Grants; Sampling; Severities; Site; Social support; Stress; Symptoms; Therapeutic; Time; United States; Visit; Withholding Treatment; Woman; Work; associated symptom; black women; cancer care; cancer health disparity; cancer therapy; chemotherapy; clinical encounter; cohort; comorbidity; comparative; design; experience; health disparity; innovation; malignant breast neoplasm; minority health; patient oriented; programs; racial difference; racial disparity; racial diversity; response; social; social determinants; social health determinants; social inclusion; survival disparity; survival outcome; symptom management; treatment disparity

Project Summary Abstract Abstract: The Symptom Experience, Management and Outcomes According to Race and Social Determinants (SEMOARS) Background: Black women with breast cancer in the United States have a lower 5 year survival than whites for stage-matched disease. Our past and ongoing work and that of others suggests that symptom incidence, cancer related distress and ineffective communication contribute to racial disparity in dose reduction and early therapy termination. Aims:1) Examine and compare chemotherapy received/chemotherapy prescribed over time and in total of matched black and white women prescribed BC chemotherapy. 2) Examine and compare the symptom incidence, distress and management, clinical encounter including patient centeredness of care and management experience of matched black and white women receiving BC chemotherapy over time. 2a) Correlate the symptom incidence symptom incidence, distress and management experience of matched black and white women receiving BC chemotherapy to Aim 1. 3) Explore the effects of social determinants of health including age, income, education, zip code and lifetime stress exposure on Aims 1, 2 and 3. Hypothesis: Inherent differences including race and possibly social determinants of health between black and white women in the experience, perception, communication and outcomes of symptoms during breast cancer chemotherapy interfere with chemotherapy adherence. Methods: Longitudinal frequent repeated-measures (18 data collections), comparative, mixed methods (audiotapes of clinic visits) descriptive design of 179 white and 179 black women from 6 sites at Western Pennsylvania and Northeast Ohio over the course of chemotherapy. Innovation: The intense assessment of symptoms, distress and quality of life and the clinical encounter in multiple repeated measures as compared by race and social determinants of health on the ability to receive full dose chemotherapy is patient centered and innovative. Significance/Public Health: If these relationships and racial differences are confirmed and the mediating factors identified as actionable targets, this information will fill a critical gap in the quality care literature, advancing the understanding and potential mitigation strategies for the static racial survival disparity in breast cancer. These identified targets hold implication for public health.

项目摘要摘要 摘要：根据种族和社会的症状经验，管理和结果 决定因素（半决赛） 背景：美国黑人乳腺癌的黑人妇女的生存率低于白人 用于阶段匹配的疾病。我们的过去和正在进行的工作以及其他工作表明症状发生率， 与癌症相关的困扰和无效的沟通有助于减少剂量和早期的种族差异 治疗终止。 目的：1）检查和比较接受的化学疗法/随着时间的流逝而开的化学疗法 匹配的黑人和白人妇女开了卑诗省化疗。 2）检查和比较症状 发病率，困扰和管理，临床遭遇，包括患者的护理和护理和 随着时间的推移，匹配的黑人和白人妇女接受BC化学疗法的管理经验。 2a） 将症状发病率的发生率，遇险和管理经验相关联 和接受BC化学疗法的白人妇女以目标1。3）探索健康决定因素的影响 包括年龄，收入，教育，邮政编码和终身压力暴露于目标1、2和3。 假设：固有的差异，包括种族，可能是黑人与健康的社会决定因素 白人妇女在乳腺癌期间的经验，感知，沟通和症状的结果 化学疗法干扰化学疗法依从性。 方法：纵向频繁重复测量（18个数据收集），比较，混合方法 （诊所访问的录音带）179名白人和179名黑人妇女的描述性设计来自西部的6个地点 在化学疗法过程中，宾夕法尼亚州和俄亥俄州东北部。 创新：对症状，苦难和生活质量以及临床相遇的严格评估 种族和健康的社会决定因素对获得全面的能力进行了多种重复措施 剂量化学疗法以患者为中心和创新。 意义/公共卫生：如果确认这些关系和种族差异并进行调解 确定为可行的目标的因素，此信息将填补优质护理文献的关键空白， 促进乳房中静态种族生存差异的理解和潜在缓解策略 癌症。这些确定的目标对公共卫生有影响。

项目成果

Factors associated with symptom distress in women with breast cancer prior to initiation of chemotherapy.

• DOI: 10.1016/j.apnr.2021.151515
• 发表时间: 2021-12
• 期刊: Applied nursing research : ANR
• 作者: Mazanec SR;Park S;Connolly MC;Rosenzweig MQ
• 通讯作者: Rosenzweig MQ

Health-related quality of life over chemotherapy course among individuals with early-stage breast cancer: the association of social determinants of health and neighborhood socioeconomic disadvantage.

早期乳腺癌患者化疗期间的健康相关生活质量：健康的社会决定因素与社区社会经济劣势的关联。

• DOI: 10.1007/s00520-024-08429-y
• 发表时间: 2024
• 期刊: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
• 作者: You,Kai-Lin;Sereika,SusanM;Bender,CatherineM;Hamilton,JillB;Mazanec,SusanR;Brufsky,Adam;Rosenzweig,MargaretQuinn
• 通讯作者: Rosenzweig,MargaretQuinn

Early-stage breast cancer menopausal symptom experience and management: exploring medical oncology clinic visit conversations through qualitative analysis.

早期乳腺癌绝经期症状体验与管理：通过定性分析探索肿瘤内科门诊就诊对话。

• DOI: 10.1007/s00520-022-07446-z
• 发表时间: 2022
• 期刊: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
• 作者: Limbacher,SarahA;Mazanec,SusanR;Frame,JenniferM;Connolly,MaryC;Park,Sumin;Rosenzweig,MargaretQ
• 通讯作者: Rosenzweig,MargaretQ

Anxiety and PTSD Symptoms During the COVID-19 Pandemic in Women With Breast Cancer.

COVID-19 大流行期间乳腺癌女性患者的焦虑和创伤后应激障碍 (PTSD) 症状。

• DOI: 10.1188/22.onf.201-205
• 发表时间: 2022
• 期刊: Oncology nursing forum
• 影响因子: 1.9
• 作者: Zhao,Jian;Mazanec,SusanR;Rosenzweig,Margaret
• 通讯作者: Rosenzweig,Margaret

Economic Hardship and Associated Factors of Women With Early-Stage Breast Cancer Prior to Chemotherapy Initiation.

早期乳腺癌女性化疗开始前的经济困难和相关因素。

• DOI: 10.1016/j.clbc.2023.09.009
• 发表时间: 2024
• 期刊: Clinical breast cancer
• 影响因子: 3.1
• 作者: Abujaradeh,Hiba;Mazanec,SusanR;Sereika,SusanM;Connolly,MaryC;Bender,CatherineM;Gordon,Brittaney-Belle;Rosenzweig,Margaret
• 通讯作者: Rosenzweig,Margaret